Introduction. Winter wheat is the main food crop grown in all soil and climatic zones of Ukraine. Harmful organisms are among the many factors that affect its yield. Under the steppe conditions, smut diseases, root rot, powdery mildew, septoriosis, orange leaf rust, various types of weeds, cereal aphids, wheat thrips, chinch bugs and others are hazardous. They lead to a significant loss of crop yield and cause deterioration in its quality [3]. Considering the foregoing, there is a need to study the effectiveness of comprehensive measures for the protection of winter wheat crops against diseases, pests and weeds. Analysis of recent research findings and publications. In many countries of the world, various aspects of winter wheat protection against harmful organisms are being investigated. In Ukraine, in particular, the application of herbicides Estrone, Grantar gold, Esteron + Puma super provided the highest