Integrated targeted serum metabolomic profile and its association with gender, age, disease severity, and pattern identification in acne

Abstract

BackgroundWesternized diet and nutritional metabolism are important in acne pathogenesis, especially in adult patients. However, clinical and basic data are lacking. Pattern identification (PI) is a tool that results in a diagnostic conclusion based on a cluster of concurrent symptoms and signs in traditional medicine. Acne can be classified by PI. However, whether the metabolomic profile differs according to the PI of acne is unknown. Metabolomic data would help clarify the pathogenesis of acne. MethodsWe conducted a cross-sectional study involving 40 healthy controls and 60 subjects with acne. We evaluated androgens, serum lipids, essential amino acids, nonessential amino acids, other amino acids, and pro-inflammatory cytokines of all subjects and compared the metabolomic profiles between acne subjects and healthy controls, and in subgroups according to gender, age, severity, and PI.

Gender-Specific Differences in Gut Microbiota Composition Associated with Microbial Metabolites for Patients with Acne Vulgaris

“…CAG polymorphism in the androgen receptor gene of female acne patients was more associated with nodulocystic acne, comparing with it in man cases 5 . Even, the serum metabolomic profile in patients with acne vulgaris was gender specific 6 . In clinical practice, hormone-based treatment has been always suggested to women patients rather than to men cases.…”

An observational study of co-relation of acne and metabolic syndrome

“…It is a pilosebaceous gland disease which usually affects people from puberty to early adulthood [3] . It is a common chronic inflammatory dermatosis that affects almost 85% of adolescents and young adults globally [4] . The prevalence of acne in adults is also rapidly increasing [5] .…”