Integrating CuO/g-C3N4 p-n heterojunctioned photocathode with MoS2 QDs@Cu NWs multifunctional signal amplifier for ultrasensitive detection of AβO

Jin-ling, Zhang; Zhang, Xuechen; Gao, Yao; Yan, Jianyue; Song, Wenbo

doi:10.1016/j.bios.2020.112945

Cited by 49 publications

(16 citation statements)

References 67 publications

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“…The peak at 235.5 eV is attributed to Mo 6+ generated by surface oxidation upon exposure to air. 54 Meanwhile, the peak of S 2s is observed at 226.0 eV, suggesting the existence of divalent sulfide ions in MoS 2 . Abovementioned XPS results imply the successful preparation of the MQD/ZIF-8@ZnO electrode.…”

Section: ■ Results and Discussionmentioning

confidence: 97%

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“Dual Signal-On” Split-Type Aptasensor for TNF-α: Integrating MQDs/ZIF-8@ZnO NR Arrays with MB-Liposome-Mediated Signal Amplification

et al. 2021

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Ultrasensitive and accurate detection of biomarkers in serum is of great importance for disease diagnosis and treatment. So far, the commonly used single-mode signal suffers from certain instinct drawbacks that restrict assay performances. Herein, we report the proof-of-concept fabrication of a split-type photoelectrochemical (PEC) and electrochemical (EC) dual-modal aptasensor for ultrasensitively tracing tumor necrosis factor-α, a noteworthy biological biomarker with essential clinical importance. By smart integrating molybdenum disulfide QDs/zeolitic imidazolate framework-8@ZnO nanorod arrays with a methylene blue-liposome-mediated signal amplification strategy, “dual signal-on” detection is accomplished based on a sandwich reaction of the target with aptamer-anchored carboxyl magnetic beads and an aptamer-confined MB liposome. Linear ranges of 5 fg/mL–5 μg/mL (detection limit 1.46 fg/mL) for PEC and 10 fg/mL–0.5 μg/mL (detection limit 6.14 fg/mL) for EC are obtained, respectively. An independent signal transduction mechanism supports the accuracy improvement, and a separate biological process from a translator enables convenient fabrication, short-time consumption, wider linearity, as well as outstanding reproducibility and stability in practical application. This work presents a universal bioassay route with prospects in biomedical and related areas.

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Section: ■ Results and Discussionmentioning

confidence: 97%

“…In Figure F, two peaks at 233.1 and 230.1 eV correspond to the Mo 3d 3/2 and Mo 3d 5/2 doublet from the Mo 4+ of MoS 2 . The peak at 235.5 eV is attributed to Mo 6+ generated by surface oxidation upon exposure to air . Meanwhile, the peak of S 2s is observed at 226.0 eV, suggesting the existence of divalent sulfide ions in MoS 2 .…”

Section: Resultsmentioning

confidence: 98%

“Dual Signal-On” Split-Type Aptasensor for TNF-α: Integrating MQDs/ZIF-8@ZnO NR Arrays with MB-Liposome-Mediated Signal Amplification

et al. 2021

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“…The n value relies on the type of optical transition of a semiconductor ( n = 1 for direct transition and n = 4 for indirect transition). The PAF-130 is an indirect gap semiconductor ( n = 4) (determined by density functional theory calculations), and the n value of g-C 3 N 4 is 4 . As a result, the E g values of PAF-130/g-C 3 N 4 , PAF-130, and g-C 3 N 4 are 2.32, 2.36, and 2.34 eV, respectively (Figure B).…”

Section: Resultsmentioning

confidence: 99%

Liposomal Controlled Release Ag-Activated DNAzyme Cycle Amplification on a 2D Pyrene COF-Based Photocathode for α-Synuclein Immunosensing

Gao

Zhang

et al. 2021

Anal. Chem.

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Ultrasensitive and accurate monitoring of ultralow-level biomarkers is imperiously needed in clinical diagnosis. So far, exploring high-performance photocathodes and developing new sensing strategies have remained central challenges in photoelectrochemical bioassays. Herein, a two-dimensional (2D) pyrene covalent organic framework (COF, PAF-130) is exemplified for the first time as a high-performance photocathode for precise immunosensing of α-synuclein (α-Syn) by integrating a DNAzyme-induced signal cycle amplification strategy with Ag nanoparticles (NPs)-mediated liposomal immunoassay. Through sequential immunobinding, lysis treatment, and acidolysis, numerous Ag+ ions are released, and then they activate the DNAzyme, which further recycles the cleavage of hairpin DNA (HDNA) on the photoelectrode and induces signal cycle amplification. As a result, an ultralow detection limit (3.6 fg/mL) and a wide linear range (10–5–103 ng/mL) are achieved, which surpass those of most methods reported so far. The proposed sensing approach can be readily extended to detect various biomarkers by substituting the biorecognition events, providing great promise for biomedical and related applications.

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“…The relatively new and rather promising photoelectrochemistry (PEC) analysis method combines the advantages of both photochemistry and electrochemistry, which completely separates the excitation source and the detection signal. 9–11 It is well known that the key to developing ultrasensitive PEC biosensors is to design materials and systems with high photoelectric conversion efficiency. For example, Zhang et al prepared semiconducting polymeric carbon nitride with ultrahigh PEC and ECL performance by microwave-assisted condensation in seconds.…”

Section: Introductionmentioning

confidence: 99%

Photoelectrochemical sandwich immunoassay of CYFRA21-1 based on In₂O₃/WO₃type-II heterojunction and CdS quantum dots-polydopamine nanospheres labeling

Liu

Sun

Liu

et al. 2022

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Integrating CuO/g-C3N4 p-n heterojunctioned photocathode with MoS2 QDs@Cu NWs multifunctional signal amplifier for ultrasensitive detection of AβO

Cited by 49 publications

References 67 publications

“Dual Signal-On” Split-Type Aptasensor for TNF-α: Integrating MQDs/ZIF-8@ZnO NR Arrays with MB-Liposome-Mediated Signal Amplification

“Dual Signal-On” Split-Type Aptasensor for TNF-α: Integrating MQDs/ZIF-8@ZnO NR Arrays with MB-Liposome-Mediated Signal Amplification

Liposomal Controlled Release Ag-Activated DNAzyme Cycle Amplification on a 2D Pyrene COF-Based Photocathode for α-Synuclein Immunosensing

Photoelectrochemical sandwich immunoassay of CYFRA21-1 based on In₂O₃/WO₃type-II heterojunction and CdS quantum dots-polydopamine nanospheres labeling

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Integrating CuO/g-C3N4 p-n heterojunctioned photocathode with MoS2 QDs@Cu NWs multifunctional signal amplifier for ultrasensitive detection of AβO

Cited by 49 publications

References 67 publications

“Dual Signal-On” Split-Type Aptasensor for TNF-α: Integrating MQDs/ZIF-8@ZnO NR Arrays with MB-Liposome-Mediated Signal Amplification

“Dual Signal-On” Split-Type Aptasensor for TNF-α: Integrating MQDs/ZIF-8@ZnO NR Arrays with MB-Liposome-Mediated Signal Amplification

Liposomal Controlled Release Ag-Activated DNAzyme Cycle Amplification on a 2D Pyrene COF-Based Photocathode for α-Synuclein Immunosensing

Photoelectrochemical sandwich immunoassay of CYFRA21-1 based on In2O3/WO3type-II heterojunction and CdS quantum dots-polydopamine nanospheres labeling

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Photoelectrochemical sandwich immunoassay of CYFRA21-1 based on In₂O₃/WO₃type-II heterojunction and CdS quantum dots-polydopamine nanospheres labeling