Integrating medicinal plants extraction into a high-value biorefinery: An example of Artemisia annua L.

Lapkin, Alexei; Adou, Eba; Mlambo, Benhilda; Chemat, Smaïn; Suberu, John O.; Collis, Alana E. C.; Clark, Andrew J.; Barker, Guy C.

doi:10.1016/j.crci.2013.10.023

Cited by 16 publications

(12 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This denoted that 100 g of dried plant material had 960 mg of artemisinin. Lapkin et al (2014) investigated the variability of metabolic profiles of A. annua grown in different geographical regions and observed differences. According to Charles et al (1990), there is variation from 0.003 to 0.39% in artemisinin content in leaves of A. annua worldwide.…”

Section: Discussionmentioning

confidence: 99%

Anthelmintic activity of Artemisia annua in sheep-model

Silva¹,

MagalhÃ£es²,

Sousa³

et al. 2017

J. Med. Plants Res.

View full text Add to dashboard Cite

Artemisia annua L. is a well-known source of artemisinin, an antimalarial drug. This compound has been used in traditional medicine to treat malaria for many years. The anthelmintic property of A. annua has also been attributed to artemisinin, hence the belief that artemisinin could be useful as an alternative anthelmintic to control Haemonchus contortus in livestock. The present study focused on evaluating the anthelmintic activity of A. annua against H. contortus by oral administration on infected sheep in a controlled clinical trial. The trial was conducted using 24 male sheep of the Santa Inês breed, with average weight of 20 kg, artificially infected with H. contortus (Embrapa 2010 isolate). The animals were kept in metabolic cages and randomly divided into four homogeneous groups with six animals each, being: (T1) negative control (untreated), (T2) positive control: 10 mg/kg BW of levamisole phosphate, (T3) fed 10% A. annua (0.2% BW), (T4) fed 20% A. annua (0.4% BW). EPG counts were conducted on days -3, -2, -1, 0 (treatment day), 3, 7, 10, 14, 17, 21, 24 and 28 post-treatment. After extraction of the artemisinin in plant material, it was quantified in triplicate and analyzed by highperformance liquid chromatography with infrared detection. The average efficacy in the positive control treated with levamisole was 89%. Moderate anthelmintic efficacy against H. contortus was observed in the groups fed 0.2 and 0.4% BW A. annua for 30 days (32.9 and 14.8%, respectively), mainly from day 21 post treatment (47.1 and 25.2%, respectively). At the highest dose, the animals avoided eating due to the compound's bitter taste. It is concluded that A. annua presents moderate anthelmintic activity in sheep in both doses. The lowest dose was accepted by animals and seems to have practical use. Oral administration was safe and after further in vivo trials could be introduced in organic farms in tropical countries.

show abstract

Section: Discussionmentioning

confidence: 99%

Anthelmintic activity of Artemisia annua in sheep-model

Silva¹,

MagalhÃ£es²,

Sousa³

et al. 2017

J. Med. Plants Res.

View full text Add to dashboard Cite

show abstract

“…Alternative commercially used hydrocarbon solvents in this extraction are toluene and hexane/ethyl acetate (95/5 v/v) mixed solvent. It was shown recently that the composition of important co-metabolites that affect solubility of artemisinin and its recoverability from the extracts is strongly dependent on the geographic origin of the biomass [18]. There is a marked difference in solubility of artemisinin in PE and hexane/EtOAc versus toluene [14].…”

Section: Industrial Extraction Processesmentioning

confidence: 99%

Green Extraction of Artemisinin from Artemisia annua L

Lapkin

2015

Green Extraction of Natural Products

View full text Add to dashboard Cite

“…For example, vegetable oils from oil palm plantations or rapeseed in Europe are employed to produce biodiesel, and plants rich in fermentable sugars such as corn, cereals, and sugarcane are processed to produce bioethanol (Jin, Yang, Poe, and Huang, 2018;Kajaste, 2014;Ubando, Felix, and Chen, 2020). However, the exploitation of this type of biomass entails a problem, since it competes for the use of land and, in traditional agriculture, these products are feedstock, which increases and volatilizes their price (Damartzis and Zabaniotou, 2011;Lapkin et al, 2014). Besides, we live in an era of human dominance that has altered biogeochemical carbon, nitrogen, phosphorus, and water cycles (Carey, Yang, McNamara, and Mayer, 2016) and affected agricultural productivity, as well as the quality and fertility of the soil.…”

Section: Introductionmentioning

confidence: 99%

“…Such waste is later used as a source of electrical energy, fuel, and/or chemicals in general (methanol) by means of a thermochemical treatment (gasification). In Colombia, a few industries have adopted this concept and recover this type of active or functional principles because their content in vegetable raw material is relatively low (Lapkin et al, 2014). Furthermore, if the energy in second-generation biomass, which is not efficiently recovered to make other functional products, given that it is generally employed as fertilizer or low-quality fuel (Bilhat Chala, Sajid Latif, 2015;Lapkin et al, 2014;Salinas Rios et al, 2014;Torres-Mancera et al, 2011), all its potential for adding value is wasted and it becomes an environmental issue (Hughes et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Biorefinery Concept Applied to Phytochemical Extraction and Bio-Syngas Production using Agro-Industrial Waste Biomass: A Review

2020

View full text Add to dashboard Cite

Second-generation biomass is a renewable resource that can address the increasing global energy demand and help to partially substitute the use of and dependence on fossil fuels, since it can be transformed into gas, liquid and/or solid fuels by physical, thermal, thermochemical and/or biological processes. However, its potential is not fully exploited because the process to extract the phytochemicals present in such organic byproducts has been largely omitted. Natural compounds are of interest to high value-added industries such as cosmetics and pharmaceutics. Therefore, this work proposes to thoroughly use such residual biomass in a biorefinery by a simultaneous, efficient and sustainable integration and operation of extraction processes to obtain phytochemicals and functional extracts. A thermochemical process known as gasification is implemented to produce syngas, which can be turned into fuels, chemicals, and energy such as methanol and synthetic gasoline. Furthermore, this review article describes the state of the art of each process and the concept of biorefinery.

show abstract

Integrating medicinal plants extraction into a high-value biorefinery: An example of Artemisia annua L.

Cited by 16 publications

References 29 publications

Anthelmintic activity of Artemisia annua in sheep-model

Anthelmintic activity of Artemisia annua in sheep-model

Green Extraction of Artemisinin from Artemisia annua L

Biorefinery Concept Applied to Phytochemical Extraction and Bio-Syngas Production using Agro-Industrial Waste Biomass: A Review

Contact Info

Product

Resources

About