Integration of 3D printing with dosage forms: A new perspective for modern healthcare

Shende, Pravin; Agrawal, Shikha

doi:10.1016/j.biopha.2018.07.167

Cited by 95 publications

(49 citation statements)

References 74 publications

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“…This is a very common technique in the pharmaceutical area [ 57 , 58 ]. As an example, Aprecia Pharmaceuticals employs it for its formulation Spritam ® (levetiracetam), becoming the first 3D printing technology medicine approved by the Food and Drug Administration (FDA) [ 59 ].…”

Section: Inkjet-based Printing Systemsmentioning

confidence: 99%

3D Printed Drug Delivery Systems Based on Natural Products

et al. 2020

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In the last few years, the employment of 3D printing technologies in the manufacture of drug delivery systems has increased, due to the advantages that they offer for personalized medicine. Thus, the possibility of producing sophisticated and tailor-made structures loaded with drugs intended for tissue engineering and optimizing the drug dose is particularly interesting in the case of pediatric and geriatric population. Natural products provide a wide range of advantages for their application as pharmaceutical excipients, as well as in scaffolds purposed for tissue engineering prepared by 3D printing technologies. The ability of biopolymers to form hydrogels is exploited in pressure assisted microsyringe and inkjet techniques, resulting in suitable porous matrices for the printing of living cells, as well as thermolabile drugs. In this review, we analyze the 3D printing technologies employed for the preparation of drug delivery systems based on natural products. Moreover, the 3D printed drug delivery systems containing natural products are described, highlighting the advantages offered by these types of excipients.

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Section: Inkjet-based Printing Systemsmentioning

confidence: 99%

3D Printed Drug Delivery Systems Based on Natural Products

et al. 2020

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“…In 1989, Scott Crump filed a patent on fused deposition modeling. Using this technique, the object is formed by depositing layers of solidifying materials (selfhardening waxes, thermoplastic resins, and molten metals) until the desired shape is formed [5,6]. In 2015, the FDA approved Spritam®, the first 3D-printed prescription drug product to treat partial onset seizures, myoclonic seizures, and primary generalized tonic-clonic seizures.…”

Section: Historymentioning

confidence: 99%

“…Even though there has been intense research to circumvent the 3D printing flaws, this new technology has still some limitations. Few 3D printing techniques may produce relatively porous structures and uneven shapes of dosage forms [6]. When fused deposition modeling technique is utilized, the use of only thermostable drugs and the few available compatible excipients is a limiting step.…”

Section: Advantages and Limitationsmentioning

confidence: 99%

“…Stereolithography employs raw materials in the liquid form, such as photosensitive/photopolymerizable liquid resins. A high-energy light source like ultraviolet irradiation solidifies the liquid resins, creating the 3D object [6]. Among the advantages of this technique are the high accuracy and good surface quality of the object.…”

Section: Various Techniques Used In 3d Printingmentioning

confidence: 99%

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3D-Printed Modified-Release Tablets: A Review of the Recent Advances

Siamidi¹,

Tsintavi²,

Rekkas³

et al. 2020

Molecular Pharmacology

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The broad spectrum of applications of three-dimensional printing (3D printing, 3DP) has attracted the attention of researchers working in diverse fields. In pharmaceutics, the main idea behind 3D printing products is to design and develop delivery systems that are suited to an individual's needs. In this way, the size, appearance, shape, and rate of delivery of a wide array of medicines could be easily adjusted. The aim of this chapter is to provide a compilation of the 3D printing techniques, used for the fabrication of oral drug delivery systems, and review the relevant scientific developments in particular those with modified-release characteristics.

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“…Despite the fast development of 3D printing in the pharmaceutical field and the market release of the first 3D printed drug product, Spritam ® (levetiracetam), there are technical and regulatory issues that need to be addressed [29]. This work aimed to update the theme of FDM 3D printing used for elaborate drug delivery devices, discussing the challenges and possible solutions that could allow this technology to enter the market.…”

Section: Introductionmentioning

confidence: 99%

The Digital Pharmacies Era: How 3D Printing Technology Using Fused Deposition Modeling Can Become a Reality

et al. 2019

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The pharmaceutical industry is set to join the fourth industrial revolution with the 3D printing of medicines. The application of 3D printers in compounding pharmacies will turn them into digital pharmacies, wrapping up the telemedicine care cycle and definitively modifying the pharmacotherapeutic treatment of patients. Fused deposition modeling 3D printing technology melts extruded drug-loaded filaments into any dosage form; and allows the obtainment of flexible dosages with different shapes, multiple active pharmaceutical ingredients and modulated drug release kinetics—in other words, offering customized medicine. This work aimed to present an update on this technology, discussing its challenges. The co-participation of the pharmaceutical industry and compounding pharmacies seems to be the best way to turn this technology into reality. The pharmaceutical industry can produce drug-loaded filaments on a large scale with the necessary quality and safety guarantees; while digital pharmacies can transform the filaments into personalized medicine according to specific prescriptions. For this to occur, adaptations in commercial 3D printers will need to meet health requirements for drug products preparation, and it will be necessary to make advances in regulatory gaps and discussions on patent protection. Thus, despite the conservatism of the sector, 3D drug printing has the potential to become the biggest technological leap ever seen in the pharmaceutical segment, and according to the most optimistic prognostics, it will soon be within reach.

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Integration of 3D printing with dosage forms: A new perspective for modern healthcare

Cited by 95 publications

References 74 publications

3D Printed Drug Delivery Systems Based on Natural Products

3D Printed Drug Delivery Systems Based on Natural Products

3D-Printed Modified-Release Tablets: A Review of the Recent Advances

The Digital Pharmacies Era: How 3D Printing Technology Using Fused Deposition Modeling Can Become a Reality

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