Integration of a flow-type chemiluminescence detector on a glass electrophoresis chip

Su, Rongguo; Lin, Jin‐Ming; Uchiyama, Katsumi; Yamada, Masaaki

doi:10.1016/j.talanta.2004.04.024

Cited by 42 publications

(26 citation statements)

References 39 publications

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“…Over the past decade, research in combining CE with CL detection has increased significantly due to its high sensitivity, easy operation, and inexpensive apparatus and reagents [102]. And some attention has been paid to its application in CEIA.…”

Section: Capillary Electrophoresismentioning

confidence: 99%

Chemiluminescence immunoassay

Zhao

Sun

Chu

2009

TrAC Trends in Analytical Chemistry

193

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Chemiluminescence immunoassay (CLIA) offers several potential advantages and has applications in clinical chemistry, bioanalysis and environmental analysis. This review covers recent developments and applications of CLIA in immunorecognition, CL markers and related techniques, and solid-phase materials. We describe automation, integration and miniaturization of CLIA. We evaluate different CLIA systems and give some pointers as to the likely directions of future developments. ª

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Section: Capillary Electrophoresismentioning

confidence: 99%

Chemiluminescence immunoassay

Zhao

Sun

Chu

2009

TrAC Trends in Analytical Chemistry

193

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“…Another glass electrophoresis microchip integrating a flow-type CL detection cell was developed and evaluated by Su et al [147]. In this case, the chip pattern is a double-Ttype electrophoretic sample injection and separation combining with a Y-type CL detector.…”

Section: Po Reactionmentioning

confidence: 99%

Advances and analytical applications in chemiluminescence coupled to capillary electrophoresis

2010

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Advances and analytical applications in chemiluminescence coupled to capillary electrophoresisThe present review presents the state of the art of the developments, key strategies and analytical applications of chemiluminescence detection coupled to CE (CE-CL). Different parts considering the most common CL systems have been included, such as the tris(2,2 0 -bipyridine)ruthenium(II) system, the luminol and derivatives reaction, the peroxyoxalate CL or direct oxidations. New advances in homemade configurations and applications in different fields such as clinical, pharmaceutical, environmental and food analysis have been included. The focus is on studies which appeared from 2000 to the end of 2009.

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“…Dopamine and catechol were separated first and then detected using a permanganate CL system. As a continuation of their work, the same group analyzed dansylated amino acids with a bis(2,4,6-trichlorophenyl)oxalate (TCPO)-H 2 O 2 system in their detector design [80]. Tsukagoshi et al [81] followed with a setup that used modified versions of a commercially available instrument and CL detector.…”

Section: Chemiluminescence and Electrochemiluminescence Detectionmentioning

confidence: 99%

Unconventional detection methods for microfluidic devices

2006

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The direction of modern analytical techniques is to push for lower detection limits, improved selectivity and sensitivity, faster analysis time, higher throughput, and more inexpensive analysis systems with ever-decreasing sample volumes. These very ambitious goals are exacerbated by the need to reduce the overall size of the device and the instrumentation -the quest for functional micrototal analysis systems epitomizes this. Microfluidic devices fabricated in glass, and more recently, in a variety of polymers, brings us a step closer to being able to achieve these stringent goals and to realize the economical fabrication of sophisticated instrumentation. However, this places a significant burden on the detection systems associated with microchip-based analysis systems. There is a need for a universal detector that can efficiently detect sample analytes in real time and with minimal sample manipulation steps, such as lengthy labeling protocols. This review highlights the advances in uncommon or less frequently used detection methods associated with microfluidic devices. As a result, the three most common methods -LIF, electrochemical, and mass spectrometric techniques -are omitted in order to focus on the more esoteric detection methods reported in the literature over the last 2 years.

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Integration of a flow-type chemiluminescence detector on a glass electrophoresis chip

Cited by 42 publications

References 39 publications

Chemiluminescence immunoassay

Chemiluminescence immunoassay

Advances and analytical applications in chemiluminescence coupled to capillary electrophoresis

Unconventional detection methods for microfluidic devices

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