Integration of Curved D-Type Optical Fiber Sensor with Microfluidic Chip

Sun, Yung-Shin; Li, Chang-Jyun; Hsu, Jin–Cherng

doi:10.3390/s17010063

Cited by 19 publications

(13 citation statements)

References 51 publications

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“…A. Woollam Company, Lincoln, NE, USA). As shown in Figure 2c (top), in most of the D-shaped and D-type OFSs, the sensing area is located in the middle of the fiber [5,9,10]. In the present OFS (see Figure 2c, bottom), the sensing area is at one end of the fiber, making it suitable for in situ and clinical applications such as direct insertion into blood vessels with a syringe.…”

Section: Methodsmentioning

confidence: 96%

“…Optical fibers, having the advantages of small size, low cost, and flexibility, provide another platform for attaining TIR, and thus SPR. A large number of SPR-based optical fiber sensors (OFSs) have been reported in measurements of temperature, refractive index, pressure, and even biomolecules [2,5]. In 1990, Villuendas and Pelayo reported one of the very first SPR-based OFSs, where the sensitivity and dynamic range in detecting aqueous sucrose solutions were experimentally determined to be 3.5 × 10 −6 RIU and 3.5 × 10 −3 RIU, respectively [6].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, a curved D-shaped OFS was designed and fabricated for sensing changes in the refractive indices of liquids. It was found that the fabrication parameters including the curvature of the fiber, the unpolished depth of the fiber core, the thickness of the deposited gold films, and the incident angle of light upon the gold-deposited surface affected the sensitivity of this sensor [5]. This OFS could be combined with a microfluidic chip for reducing sample consumption in biological applications [5].…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of a Bare Optical Fiber-Based Biosensor

et al. 2019

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A bare optical fiber-based biosensor is proposed for measuring the refractive index of different liquids and the binding kinetics of biomolecules to the sensor surface. This optical fiber sensor is based on the Kretschmann’s configuration to attain total internal reflection (TIR) for surface plasmon resonance (SPR) excitation. One end of the bare optical fiber is coated with a gold film. By guiding the light source from the other end into the optical fiber, the light is reflected from the gold-deposited end and the surface evanescent wave is excited in the gold film-transparent material interface. Methanol and ethanol solutions with different refractive indices are used for measuring the corresponding changes in the peak values of the spectra and calculating the corresponding sensitivities. These values are experimentally determined to be in the order of 10−4~10−5 refractive index unit (RIU). Binding of proteins onto the sensor surface is also monitored in real time to obtain the binding kinetics. We believe that, in the future, this optical fiber sensor can serve as a useful biosensor for in situ measurement of allergens, antibody–antigen interactions, and even circulating tumor cells in the blood.

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Section: Methodsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fabrication of a Bare Optical Fiber-Based Biosensor

et al. 2019

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“…and Lim, 2002;Ko and Grant, 2006;Liu et al, 2003;Ohk and Bhunia, 2012;Sharma and Mutharasan, 2013). At present, the focus is shifting towards the integration of SPR into microfluidic systems to establish versatile lab-on-fibre technology for the POC applications (Blue and Uttamchandani, 2016;Chen et al, 2016;Lin et al, 2015;Luka et al, 2015;Oscar et al, 2017;Ricciardi et al, 2015;Sun et al, 2016;M. Yin et al, 2016).…”

Section: Optical Fibre Biosensorsmentioning

confidence: 99%

Microfluidic devices for sample preparation and rapid detection of foodborne pathogens

Kant

Shahbazi

Dave

et al. 2018

Biotechnology Advances

152

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Rapid detection of foodborne pathogens at an early stage is imperative for preventing the outbreak of foodborne diseases, known as serious threats to human health. Conventional bacterial culturing methods for foodborne pathogen detection are time consuming, laborious, and with poor pathogen diagnosis competences. This has prompted researchers to call the current status of detection approaches into question and leverage new technologies for superior pathogen sensing outcomes. Novel strategies mainly rely on incorporating all the steps from sample preparation to detection in miniaturized devices for online monitoring of pathogens with high accuracy and sensitivity in a time-saving and cost effective manner. Lab on chip is a blooming area in diagnosis, which exploits different mechanical and biological techniques to detect very low concentrations of pathogens in food samples. This is achieved through streamlining the sample handling and concentrating procedures, which will subsequently reduce human errors and enhance the accuracy of the sensing methods. Integration of sample preparation techniques into these devices can effectively minimize the impact of complex food matrix on pathogen diagnosis and improve the limit of detections. Integration of pathogen capturing bio-receptors on microfluidic devices is a crucial step, which can facilitate recognition abilities in harsh chemical and physical conditions, offering a great commercial benefit to the food-manufacturing sector. This article reviews recent advances in current state-of-the-art of sample preparation and concentration from food matrices with focus on bacterial capturing methods and sensing technologies, along with their advantages and limitations when integrated into microfluidic devices for online rapid detection of pathogens in foods and food production line.

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“…In general, these sensors have delivered encouraging results and demonstrated great potential for ethanol sensing in a wide range of applications. Figure 1 is a graphical summary of a selection of applications for ethanol sensing and optical fibre sensing schemes utilised for ethanol sensing extracted from recent literature [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ] and includes sensor design parameters and typical output responses. Several articles have recently outlined and reflected on the advancement of optical fibre chemical and biosensors from various perspectives [ 31 , 32 , 44 , 45 , 46 , 47 , 48 ].…”

Section: Introductionmentioning

confidence: 99%

A Review of Optical Fibre Ethanol Sensors: Current State and Future Prospects

Memon

Wang

Strunz

et al. 2022

Sensors

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A range of optical fibre-based sensors for the measurement of ethanol, primarily in aqueous solution, have been developed and are reviewed here. The sensing approaches can be classified into four groups according to the measurement techniques used, namely absorption (or absorbance), external interferometric, internal fibre grating and plasmonic sensing. The sensors within these groupings can be compared in terms of their characteristic performance indicators, which include sensitivity, resolution and measurement range. Here, particular attention is paid to the potential application areas of these sensors as ethanol production is globally viewed as an important industrial activity. Potential industrial applications are highlighted in the context of the emergence of the internet of things (IoT), which is driving widespread utilization of these sensors in the commercially significant industrial and medical sectors. The review concludes with a summary of the current status and future prospects of optical fibre ethanol sensors for industrial use.

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Integration of Curved D-Type Optical Fiber Sensor with Microfluidic Chip

Cited by 19 publications

References 51 publications

Fabrication of a Bare Optical Fiber-Based Biosensor

Fabrication of a Bare Optical Fiber-Based Biosensor

Microfluidic devices for sample preparation and rapid detection of foodborne pathogens

A Review of Optical Fibre Ethanol Sensors: Current State and Future Prospects

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