In order to improve the prediction accuracy of the slope deformation prediction method in mining area, aiming at the problems of many disaster causing factors of slope deformation and BP neural network is easy to fall into local minimum value, a prediction method based on the combination of genetic algorithm and BP neural network based on grey correlation analysis is proposed. The grey correlation analysis method is used to screen the main influencing factors, and the factors with high correlation degree are used as input indexes to simplify the network structure. Then, the genetic algorithm is used to optimize the BP neural network to establish the GA-BP model, and finally the prediction is compared. The results show that the grey correlation analysis can further improve the consistency between the predicted value and the real value, and the model can accurately predict the slope deformation. The research results have important auxiliary reference significance for mine safety production.