Integrative Analysis of HNF1B mRNA in Human Cancers Based on Data Mining

Abstract

Cancer incidence is rapidly growing, and cancer is the leading cause of death worldwide in the 21st century. Hepatocyte nuclear factor 1B (HNF1B) is a transcription factor that involves the growth and development of multiple organs. The aim of this study was to explore the significance of HNF1B in human cancer by an integrative analysis of online databases. The UALCAN database, cBio cancer genomics portal, Cancer Regulome tools, Kaplan-Meier plotter and Tumor IMmune Estimation Resource (TIMER) website were used to perform the corresponding analysis. The results showed that HNF1B is dysregulated in various cancers and associated with the differential overall survival of cancer patients. HNF1B showed many mutation forms and high mutation levels in different cancer types. In addition, we found that HNF1B interacted with different genes in multiple aspects. Moreover, HNF1B expression is associated with many immune cell infiltration levels and influences the prognostic prediction of immune cells in some kinds of cancers. In conclusion, HNF1B plays a significant role in cancer and may be a potential target for cancer immunotherapy.

Hepatocyte nuclear factor 1 beta: A perspective in cancer

“…This study emphasizes the correlation amongst HNF1B and immune cells and the need for further investigation into the HNF1B expression for patients undergoing immunotherapy. Moreover, the group also demonstrated HNF1B mRNA dysregulation in different cancers that lead to differential expression of HNF1B leading to distinct prognosis 117 …”

“…HNF1B expression is associated along with heterogenous immune cell infiltration levels in distinct cancers. 117 For instance, HNF1B expression is correlated with the infiltration grades of B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils along with Dendritic cells in cancer. Patients were categorized into low and high HNF1B expression groups based on the CD4+ T cell, CD8+ T cell along with B-cell levels, which were further grouped based on overall survival of cancer patients into different subsets.…”

“…In the latest study by Nie et al, HNF1B expression was observed to be higher in uterine corpus endometrial carcinoma, bladder urothelial carcinoma and liver hepatocellular carcinoma and minimal expression levels in liver hepatocellular carcinoma, colon carcinoma, glioblastoma multiforme, kidney chromophobe and kidney renal clear cell carcinoma. HNF1B expression is associated along with heterogenous immune cell infiltration levels in distinct cancers 117 . For instance, HNF1B expression is correlated with the infiltration grades of B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils along with Dendritic cells in cancer.…”

“…Moreover, the group also demonstrated HNF1B mRNA dysregulation in different cancers that lead to differential expression of HNF1B leading to distinct prognosis. 117 Pancreatic abnormalities have been tested for HNF1B mutations and its prospectus as a biomarker being widely debated in renal hyperplasia and cysts. 118 Yang and colleagues investigated the role of HNF1B in PDAC as a diagnostic marker in a large cohort of 127 primary and 17 metastatic PDACs, 47 biliary adenocarcinoma and 231 pancreaticobiliary carcinomas.…”

Single‐cell transcriptomic survey of cell diversity and functional changes in yak hearts at different altitude

“…A large number of genes are enriched in the "vascular smooth cell contraction" pathway, which may make blood vessels more contractile and more able to regulate blood vessel thickness and distribution and blood flow velocity [32,33]. A large number of genes are enriched in the "cGMP-PKG signaling pathway," which improves adaptability to high altitudes but may also increase the possibility of cardiovascular disease [34,35]. These genes are related to the regulation of contractility and relaxation of smooth muscle cells and help regulate blood pressure and flow, ensuring blood supply.…”