Intellectual Function in Patients with Anorexia Nervosa and Bulimia Nervosa

Weider, Siri; Indredavik, Marit S.; Lydersen, Stian; Hestad, Knut

doi:10.1002/erv.2260

Cited by 20 publications

(19 citation statements)

References 84 publications

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“…Recent studies also showed variable results. In a small study, borderline intelligence levels were seen in severe restricting‐type AN patients but Weider et al found average intelligence levels in AN patients but higher intelligence levels in BN patients (especially with respect to PIQ) shortly after admission to full‐time care. Kjaersdam Telleus et al found, in adolescent AN patients, FSIQ close to normal, but significantly worse PIQ compared to a healthy control group.…”

Section: Discussionmentioning

confidence: 96%

“…Despite this growing interest in (high) intelligence as a possible vulnerability marker for development of EDs, intelligence levels in ED patients are not extensively studied yet. A few studies and one systematic review, predominantly in anorexia nervosa (AN) patients, showed that intelligence levels are as high as, or probably higher than in the general population …”

Section: Introductionmentioning

confidence: 99%

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Intellectual functioning of adolescent and adult patients with eating disorders

Schilder

Elburg

Snellen

et al. 2016

Intl J Eating Disorders

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Intellectual functioning of adolescent and adult patients with eating disorders

Schilder

Elburg

Snellen

et al. 2016

Intl J Eating Disorders

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“…Recent studies investigating intelligence levels in anorexia nervosa [74,75] do not speak in favor of significantly reduced intelligence in anorexia nervosa. Furthermore, in our sample, there was no significant difference in the educational level between patients and healthy controls, making a significant difference in the intelligence level and thus a confounding effect on our results unlikely.…”

Section: Limitationsmentioning

confidence: 89%

Evidence for alterations of cortical folding in anorexia nervosa

Schultz

Wagner

Cruz

et al. 2015

Eur Arch Psychiatry Clin Neurosci

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Anorexia nervosa (AN) is highly heritable, and the perspective on the etiology of AN has changed from a behavioral to a neurobiological and neurodevelopmental view. However, cortical folding as an important marker for deviations in brain development has yet rarely been explored in AN. Hence, in order to determine potential cortical folding alterations, we investigated fine-grained cortical folding in a cohort of 26 patients with AN, of whom 6 patients were recovered regarding their weight at the time point of MRI measurement. MRI-derived cortical folding was computed and compared between patients and healthy controls at about 150,000 points per hemisphere using a surface-based technique (FreeSurfer). Patients with AN exhibited highly significant increased cortical folding in a right dorsolateral prefrontal cortex region (DLPFC). Furthermore, a statistical trend in the same direction was found in the right visual cortex. We did not find a correlation of local cortical folding and current symptoms of the disease. In conclusion, our analyses provide first evidence that altered DLPFC cortical folding plays a role in the etiology of AN. The absence of correlations with clinical parameters implicates a relatively independence of cortical folding alterations from the current symptomatology and might thus be regarded as a trait characteristic of the disease potentially related to other neurobiological features of AN.

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“…Although this could be explained by the fact that the length of stay required by those patients is shorter, it could also be a result of a higher degree of cognitive impairment in those with lower weight at entry. Making early engagement with treatment in patients with cognitive difficulties may be more difficult as recent studies have demonstrated an association between cognitive function and low BMI (Chan et al, ; Weider, Indredavik, Lydersen, & Hestad, 2014). However, the relationship between BMI and cognitive functioning is complex, and our clinical impression is that some patients at low BMI still perform astonishingly well, for example, by continuing with their studies and work even at very low weights.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Positive Treatment Outcome in People With Anorexia Nervosa Treated in a Specialized Inpatient Unit: The Role of Early Response to Treatment

Wales

Brewin

Cashmore

et al. 2016

Euro Eating Disorders Rev

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Objective To investigate factors which predict positive treatment outcome in inpatients with anorexia nervosa (AN), particularly the role of early treatment response. Method 102 patients entering specialist inpatient treatment were assessed for eating disorder history, psychopathology, and motivation to change. Predictive factors assessed were: early treatment response defined as weight increase of at least 0.5–1 kg/week during the first 6 weeks of treatment (n=87), admission body mass index (BMI), onset age, chronicity, motivation to change, diagnosis, and previous hospitalization for AN. Positive treatment outcome was defined as achieving a BMI of 17.5 kg/m2 within an individual time frame. Results Logistic regression indicated that patients were 18 times more likely to reach positive treatment outcome if they met the National Institute for Health and Care Excellence weight guidelines within the first 6 weeks of hospitalization. Higher admission BMI was also found to predict positive treatment outcome. Discussion Higher entry BMI and early weight gain predict positive treatment outcome in individuals receiving specialist AN inpatient treatment. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.

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Intellectual Function in Patients with Anorexia Nervosa and Bulimia Nervosa

Cited by 20 publications

References 84 publications

Intellectual functioning of adolescent and adult patients with eating disorders

Intellectual functioning of adolescent and adult patients with eating disorders

Evidence for alterations of cortical folding in anorexia nervosa

Predictors of Positive Treatment Outcome in People With Anorexia Nervosa Treated in a Specialized Inpatient Unit: The Role of Early Response to Treatment

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