Intelligent intraoral drug delivery microsystem

Velten, Thomas; Schuck, H.; Knoll, Thorsten; Scholz, Oliver; Schumacher, Axel; Göttsche, Thorsten; Wolff, Ändy; Beiski, Ben Z.

doi:10.1243/09544062jmes237

Cited by 12 publications

(4 citation statements)

References 5 publications

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“…Many groups have also used osmotic mechanisms to drive flows in microfluidic systems , Velten et al 2006, Good et al 2007, Xu et al 2010. Jensen et al (2009Jensen et al ( , 2011 appear to be the first to have connected this strategy to the Münch hypothesis.…”

Section: Synthetic Mimics Of Transport Processes In Plantsmentioning

confidence: 99%

The Physicochemical Hydrodynamics of Vascular Plants

Stroock

Pagay

Zwieniecki

et al. 2014

Annu. Rev. Fluid Mech.

176

188

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Plants live dangerously, but gracefully. To remain hydrated, they exploit liquid water in the thermodynamically metastable state of negative pressure, similar to a rope under tension. This tension allows them to pull water out of the soil and up to their leaves. When this liquid rope breaks, owing to cavitation, they catch the ends to keep it from unraveling and then bind it back together. In parallel, they operate a second vascular system for the circulation of metabolites though their tissues, this time with positive pressures and flow that passes from leaf to root. In this article, we review the current state of understanding of water management in plants with an emphasis on the rich coupling of transport phenomena, thermodynamics, and active biological processes. We discuss efforts to replicate plant function in synthetic systems and point to opportunities for physical scientists and engineers to benefit from and contribute to the study of plants.

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Section: Synthetic Mimics Of Transport Processes In Plantsmentioning

confidence: 99%

The Physicochemical Hydrodynamics of Vascular Plants

Stroock

Pagay

Zwieniecki

et al. 2014

Annu. Rev. Fluid Mech.

176

188

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“…Due to the presence of a large sugar source reservoir, this bioinspired osmotic pump can run at steady-state for several hours or more, allowing precise measurements of the physicochemical coupling at the system scale. It may also provide new strategies for pumping microscale flows in lab-on-a-chip applications (20)(21)(22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Passive phloem loading and long-distance transport in a synthetic tree-on-a-chip

et al. 2017

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Vascular plants rely on differences of osmotic pressure to export sugars from regions of synthesis (mature leaves) to sugar sinks (roots, fruits). In this process, known as Münch pressure flow, the loading of sugars from photosynthetic cells to the export conduit (the phloem) is crucial, as it sets the pressure head necessary to power long-distance transport. Whereas most herbaceous plants use active mechanisms to increase phloem concentration above that of the photosynthetic cells, in most tree species, for which transport distances are largest, loading seems to occur via passive symplastic diffusion from the mesophyll to the phloem. Here, we use a synthetic microfluidic model of a passive loader to explore the nonlinear dynamics that arise during export and determine the ability of passive loading to drive long-distance transport. We first demonstrate that in our device, phloem concentration is set by the balance between the resistances to diffusive loading from the source and convective export through the phloem. Convection-limited export corresponds to classical models of Münch transport, where phloem concentration is close to that of the source; in contrast, diffusion-limited export leads to small phloem concentrations and weak scaling of flow rates with the hydraulic resistance. We then show that the effective regime of convection-limited export is predominant in plants with large transport resistances and low xylem pressures. Moreover, hydrostatic pressures developed in our synthetic passive loader can reach botanically relevant values as high as 10 bars. We conclude that passive loading is sufficient to drive long-distance transport in large plants, and that trees are well suited to take full advantage of passive phloem loading strategies.

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“…Fouling, being the accumulation of undesired contaminants such as organic molecules, cells, and microparticles on a submerged surface, forms a problem for many applications. [1,2] One example of mentioned previously is aligned in a regular patten, which can limit the self-cleaning capabilities. In particular, it was found that when the particle sizes are close to the cilia pitch (the spacing of adjacent cilia), the cleaning effectiveness is reduced.…”

Section: Introductionmentioning

confidence: 99%

“…Fouling, being the accumulation of undesired contaminants such as organic molecules, cells, and microparticles on a submerged surface, forms a problem for many applications. [ 1,2 ] One example of such an application is lab‐on‐a‐chip devices, as the absorption of microparticles, cells of molecules to the device walls, or the accumulation of these contaminants in microfluidic channels, inhibits normal device operation, for example, causing microchannel clogging. [ 3 ] Another example are submerged sensor surfaces for environmental monitoring in oceans, lakes, or rivers, or in chemical and food processing operations, where fouling can lead to reduced sensitivity and/or lifetime.…”

Section: Introductionmentioning

confidence: 99%

Self‐Cleaning Surfaces Realized by Biologically Sized Magnetic Artificial Cilia

Cui

Zhang

Wang

et al. 2021

Adv Materials Inter

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Magnetic artificial cilia (MAC) are small actuators inspired by biological cilia found in nature. In microfluidic chips, MAC can generate flow and remove microparticles, with applications in anti‐fouling. However, the MAC used for anti‐fouling in the current literature has dimensions of several hundred micrometers in length, which limits the application to relatively large length scales. Here, biologically‐sized magnetic artificial cilia (b‐MAC) which are only 45 micrometers long and that are randomly distributed on the surface, are used to remove microparticles. It is shown that microparticles with sizes ranging from 5 to 40 µm can be removed efficiently and the final cleanness ranges from 69% to 100%, with the highest cleanness for the highest actuation frequency applied (40 Hz). The lowest cleanness is obtained for microparticles with a size equal to the average pitch between the b‐MAC. The randomness in cilia distribution appears to have a positive effect on cleanliness, compared with the authors’ earlier work using a regular cilia array. The demonstrated self‐cleaning by the b‐MAC constitutes an essential step toward efficient self‐cleaning surfaces for real‐life application in miniaturized microfluidic devices, such as lab‐on‐a‐chip or organ‐on‐a‐chip devices, as well as for preventing fouling of submerged surfaces such as marine sensors.

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Intelligent intraoral drug delivery microsystem

Cited by 12 publications

References 5 publications

The Physicochemical Hydrodynamics of Vascular Plants

The Physicochemical Hydrodynamics of Vascular Plants

Passive phloem loading and long-distance transport in a synthetic tree-on-a-chip

Self‐Cleaning Surfaces Realized by Biologically Sized Magnetic Artificial Cilia

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