Intelligent nanoflowers: a full tumor microenvironment-responsive multimodal cancer theranostic nanoplatform

Jing, Xunan; Xu, Yanzi; Liu, Daomeng; Wu, Youshen; Zhou, Na; Wang, Daquan; Yan, Kai; Meng, Lingjie

doi:10.1039/c9nr04768a

Cited by 72 publications

(48 citation statements)

References 41 publications

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“…It is noteworthy that the light irradiation power density (50 mW/cm 2 ) and irradiation dose (≤5.25 J/cm 2 ) in this study are a lot lower than those used on other oxygen-generating Ce6 nanoparticles, which relied on MnO 2 (150 mW/cm 2 , 90 J/cm 2 [ 72 ] or 100 mW/cm 2 , 30 J/cm 2 [ 56 ]) or H 2 O 2 (750 mW/cm 2 , 45 J/cm 2 [ 73 ]) decomposition to produce O 2 . This supports the applicability of our PFPE-based nanoformulation (i.e., Ce6-P/W NE) in delivering a large amount of O 2 to the hypoxic tumor site, consequently improving PDT efficiency.…”

Section: Resultsmentioning

confidence: 99%

Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

et al. 2020

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Sonodynamic therapy (SDT) has emerged as an important modality for cancer treatment. SDT utilizes ultrasound excitation, which overcomes the limitations of light penetration in deep tumors, as encountered by photodynamic therapy (PDT) which uses optical excitations. A comparative study of these modalities using the same sensitizer drug can provide an assessment of their effects. However, the efficiency of SDT and PDT is low in a hypoxic tumor environment, which limits their applications. In this study, we report a hierarchical nanoformulation which contains a Food and Drug Administration (FDA) approved sensitizer chlorin, e6, and a uniquely stable high loading capacity oxygen carrier, perfluoropolyether. This oxygen carrier possesses no measurable cytotoxicity. It delivers oxygen to overcome hypoxia, and at the same time, boosts the efficiency of both SDT and PDT. Moreover, we comparatively analyzed the efficiency of SDT and PDT for tumor treatment throughout the depth of the tissue. Our study demonstrates that the strengths of PDT and SDT could be combined into a single multifunctional nanoplatform, which works well in the hypoxia environment and overcomes the limitations of each modality. The combination of deep tissue penetration by ultrasound and high spatial activation by light for selective treatment of single cells will significantly enhance the scope for therapeutic applications.

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Section: Resultsmentioning

confidence: 99%

Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

et al. 2020

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“…They further checked the effect of magnetic targeting on MRI and showed that tumor targeting and retention of the NPs was further increased under the influence of magnetic field, resulting in the appearance of much enhanced signal intensity in T2-weighted MR images within the tumor. Jing et al (2019) constructed nanoflower composites of Fe 3 O 4 NPs core with MnO 2 nanoshell for CT imaging in vitro in HeLa cells. Besides, the nanocomposites containing Mn 2+ and Fe 3 O 4 also exhibited in vivo T2/T1-weighted MRI response and a characteristic concentration dependent darkening and brightening effect of negative T2 and positive T1-MR contrast agent.…”

Section: Cancer Theranostics Application Of Immunomodulatory Nanopartmentioning

confidence: 99%

Nanoparticles as Smart Carriers for Enhanced Cancer Immunotherapy

Thakur

Chatterjee

et al. 2020

Front. Chem.

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Cancer immunotherapy has emerged as a promising strategy for the treatment of many forms of cancer by stimulating body's own immune system. This therapy not only eradicates tumor cells by inducing strong anti-tumor immune response but also prevent their recurrence. The clinical cancer immunotherapy faces some insurmountable challenges including high immune-mediated toxicity, lack of effective and targeted delivery of cancer antigens to immune cells and off-target side effects. However, nanotechnology offers some solutions to overcome those limitations, and thus can potentiate the efficacy of immunotherapy. This review focuses on the advancement of nanoparticle-mediated delivery of immunostimulating agents for efficient cancer immunotherapy. Here we have outlined the use of the immunostimulatory nanoparticles as a smart carrier for effective delivery of cancer antigens and adjuvants, type of interactions between nanoparticles and the antigen/adjuvant as well as the factors controlling the interaction between nanoparticles and the receptors on antigen presenting cells. Besides, the role of nanoparticles in targeting/activating immune cells and modulating the immunosuppressive tumor microenvironment has also been discussed extensively. Finally, we have summarized some theranostic applications of the immunomodulatory nanomaterials in treating cancers based on the earlier published reports.

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“…showed that an intelligent nanoflower composite (FHCPC@MnO 2 ) could exploit the low pH and high levels of H 2 O 2 and GSH that exist in the TME ( Figure a). [ 85,86 ] IONP nanoclusters were encapsulated with a GSH and a pH‐responsive polyphosphazene (PPZ)‐drug conjugate layer and was then coated with a MnO 2 shell. In a slightly acidic, H 2 O 2 and GSH‐rich environment, the MnO 2 and PPZ layers were degraded.…”

Section: Internal Targets For Nanomaterials Activationmentioning

confidence: 99%

“…Reproduced with permission. [ 86 ] Copyright 2019, The Royal Society of Chemistry. A hybrid protein@inorganic nanodumpling (ND) system was designed to be activated by thiols, such as GSH, and low pH.…”

Section: Internal Targets For Nanomaterials Activationmentioning

confidence: 99%

Internally Responsive Nanomaterials for Activatable Multimodal Imaging of Cancer

Rosenkrans

Ferreira

et al. 2020

Adv Healthcare Materials

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Advances in technology and nanomedicine have led to the development of nanoparticles that can be activated for multimodal imaging of cancer, where a stimulus induces a material modification that enhances image contrast. Multimodal imaging using nanomaterials with this capability can combine the advantages and overcome the limitations of any single imaging modality. When designed with stimuli‐responsive abilities, the target‐to‐background ratio of multimodal imaging nanoprobes increases because specific stimuli in the tumor enhance the signal. Several aspects of the tumor microenvironment can be exploited as an internal stimulus response for multimodal imaging applications, such as the pH gradient, redox processes, overproduction of various enzymes, or combinations of these. In this review, design strategies are discussed and an overview of the recent developments of internally responsive multimodal nanomaterials is provided. Properly implementing this approach improves noninvasive cancer diagnosis and staging as well as provides a method to monitor drug delivery and treatment response.

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Intelligent nanoflowers: a full tumor microenvironment-responsive multimodal cancer theranostic nanoplatform

Abstract: Multistage pH/H2O2/redox-responsive 3D nanoflowers that fully exploit the tumor microenvironment achieve highly specific guided multimode diagnosis with excellent synergistic chemotherapy and photodynamic therapy effects both in vitro and in vivo.

Cited by 72 publications

References 41 publications

Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

Nanoparticles as Smart Carriers for Enhanced Cancer Immunotherapy

Internally Responsive Nanomaterials for Activatable Multimodal Imaging of Cancer

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