Intensity of acute exercise does not affect serum leptin concentrations in young men

Weltman, Arthur; Pritzlaff, C. J.; Wideman, Laurie; Considine, Robert V.; Fryburg, David A.; Gutgesell, Margaret E.; Hartman, Mark L.; Veldhuis, Johannes D.

doi:10.1097/00005768-200009000-00005

Cited by 74 publications

(23 citation statements)

References 27 publications

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“…Thus, the major finding of our study was that only prolonged strenuous endurance exercises involving elevated energy expenditure reduced serum leptin concentrations. Previous reports on the effect of exercise on serum leptin concentrations are contradictory: acute exercise lasting 30 min, performed at different intensities and caloric expenditure (Weltman et al 2000), and a 20-mile (32.2 km) treadmill run (Hickey et al 1996) did not affect serum leptin concentrations, while a 3-h cycle ergometer exercise bout induced a 42% decrease in serum leptin (Koistinen et al 1998). Studies on marathon runners, on the other hand, showed either no changes (Koistinen et al 1998) or a slight (11%), but significant reduction (Tuominen et al 1997) in leptin levels.…”

Section: Discussionmentioning

confidence: 97%

Leptin reduction after endurance races differing in duration and energy expenditure

Zaccaria

Ermolao

Roi³

et al. 2002

European Journal of Applied Physiology

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Serum leptin concentrations are reduced in the presence of a negative energy balance. It has been demonstrated, however, that strenuous and prolonged exercise, which induces a marked negative energy balance, is not always followed by a reduction in serum leptin levels. We therefore analysed serum leptin concentrations before and after three endurance races, which differed in duration and energy expenditure (EE), with the aim of clarifying the relationship between the level of EE and the reduction in leptin levels. Forty-five males participated in one of three competitive endurance races, a half-marathon run [21.097 km, estimated EE 1,400 kcal (5,852 kJ)], a ski-alpinism race [about 45 km, estimated EE 5,000 kcal (20,900 kJ)], and an ultramarathon race [100 km, estimated EE 7,000 kcal (29,269 kJ)]. Blood samples for analysis of serum leptin, and plasma free fatty acids (FFA) were collected before and after the races. Pre-race leptin values were significantly correlated with both body mass index and body fat mass ( r=0.672 and r=0.699, respectively; P<0.0001). After exercise, serum leptin levels decreased significantly in the ultramarathon [from 4.15 (0.63) microg/l to 1.01 (0.15) microg/l; P<0.001] and in the ski-alpinism race [from 1.10 (0.28) microg/l to 0.62 (0.15) microg/l; P<0.01], but not in the half-marathon [from 1.38 (0.40) microg/l to 1.20 (0.36) microg/l]. Plasma FFA were found to have significantly increased in all three of the races, showing a negative correlation with the percent reduction in leptin ( r=0.369, P<0.02). Our data indicate that only a prolonged endurance exercise involving a high EE can induce a marked reduction in circulating serum leptin levels.

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Section: Discussionmentioning

confidence: 97%

Leptin reduction after endurance races differing in duration and energy expenditure

Zaccaria

Ermolao

Roi³

et al. 2002

European Journal of Applied Physiology

View full text Add to dashboard Cite

show abstract

“…The effect of exercise on leptin is also potentially important in relation to insulin action [24][25][26][27]. Most studies examined the effects of aerobic exercise on serum leptin by the utilization of continuous running regimens [5,26,28,29]. Most of these studies have reported a reduction or no change in leptin concentrations.…”

Section: Introductionmentioning

confidence: 99%

“…There is thus the potential that individuals with larger fat masses respond differently to exercise than leaner subjects in terms of leptin [10]. Evidence suggests that, in trained individuals, acute exercise has no effects on circulating leptin levels [29,[32][33][34][35]. Exercise can improve metabolic risk variables such as insulin and leptin in overweight and obese post-menopausal women [8].…”

Section: Introductionmentioning

confidence: 99%

Acute effects of aerobic and resistance exercises on serum leptin and risk factors for coronary heart disease in obese females

et al. 2008

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Six young obese females (20.5±1.22 years; BMI=34.5±4.3 kg/m 2 ) participated in a resistance exercise (RE) protocol (12 exercises, 4 sets × 15 repetitions at 60% of 1RM), an aerobic exercise (AE) protocol (3 sets × 10 min ergometer cycling at 60% of maximal heart rate with 5 min of rest between sets), and a control session. Blood samples were collected before, and immediately after and 10 h after exercise. All protocols were done in follicular phase of the menstrual cycle. ANOVA (3×3) with repeated measure on exercise (3 levels) and time (3 levels) factors was used to determine the effects of exercise protocol, time and exercise protocol by blood sampling time interaction, triglycerides, HDL-cholesterol, LDL-cholesterol, and glucose concentrations. Immediately and 10 h after AE, serum leptin was significantly lower (p<0.05). Serum insulin after AE was lower than after RE and control sessions (p<0.05). Furthermore, no significant differences were found in serum leptin and insulin between RE and control sessions immediately after and 10 h after exercise. Blood glucose, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol were unchanged in both exercise protocols. In conclusion, AE resulted in a serum leptin reduction and suppressed the circadian rhythm of serum insulin when sampled immediately and 10 h after exercise; instread, RE did not result in serum leptin or insulin changes.

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“…Blood samples were collected before, immediately after sculling exercise, and 30 min post-exercise of constant load sculling exercises (Jürimäe et al 2006a, b). Similar to other recent studies, no control trial was conducted as diurnal changes of measured hormones were considered not to occur during this short time period (Ferguson et al 2004;Jürimäe et al 2006a, b;Weltman et al 2000). The plasma was separated and frozen at ¡20°C for subsequent analysis.…”

Section: Blood Analysismentioning

confidence: 99%

Plasma ghrelin responses to acute sculling exercises in elite male rowers

et al. 2006

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The regulatory effect of ghrelin on growth hormone (GH) is limited in describing ghrelin response to acute submaximal exercise intensities in elite athletes. We investigated the effects of a single sculling exercise performed above and below the individual anaerobic threshold (IAT) on total ghrelin concentration in highly trained male rowers. Nine elite male rowers (20.1 +/- 3.7 years; 190.0 +/- 5.2 cm; 89.6 +/- 4.6 kg; %body fat: 9.9 +/- 2.5%) volunteered for this study. Single scull rowing was performed below and above IAT using a mean of 5 bpm above and below the heart rate of the IAT during graded exercise test. Ghrelin, leptin, GH, insulin, and glucose were measured before, immediately after, and after 30 min of recovery. Plasma ghrelin concentration did not increase significantly in either exercise but was approaching significance after 30 min of recovery (P = 0.051) when the constant load sculling was performed at the intensity above the IAT. There were no changes in plasma leptin levels. GH increased significantly immediately after exercise and remained elevated during the 30 min of recovery in both exercise conditions, while insulin decreased significantly immediately after exercise and remained significantly lower after the 30 min of recovery in both exercise intensities. Baseline ghrelin was not correlated with the body composition, physical performance, or blood biochemical data. There was no significant relationship between plasma ghrelin and other blood variables immediately after the 30 min of recovery in both exercise tests and changes in ghrelin were not related to blood biochemical variables after the exercise tests. The acute constant load sculling exercise above or below IAT that increased GH concentrations did not significantly increase the circulating plasma ghrelin levels.

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Intensity of acute exercise does not affect serum leptin concentrations in young men

Abstract: We conclude that 30 min of acute exercise, at varying intensity of exercise and caloric expenditure, does not affect serum leptin concentrations during exercise or for the first 3.5 hours of recovery in healthy young men.

Cited by 74 publications

References 27 publications

Leptin reduction after endurance races differing in duration and energy expenditure

Leptin reduction after endurance races differing in duration and energy expenditure

Acute effects of aerobic and resistance exercises on serum leptin and risk factors for coronary heart disease in obese females

Plasma ghrelin responses to acute sculling exercises in elite male rowers

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