Inter-relationship of serum leptin levels with selected anthropometric parameters among a non-diabetic population: a cross-sectional study

Kaneshapillai, Anusha; Hettiaratchi, Usha; Athiththan, L.V.; Perera, Rasika

doi:10.1007/s40519-017-0413-x

Cited by 6 publications

(9 citation statements)

References 20 publications

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“…Circulating leptin concentrations are known to reflect total body fat and to be higher in females than in males. In our patients, serum leptin in men and women did not differ, and its levels were comparable with those of control subjects in previous studies [33,34]. Leptin was lower in children, as could be expected.…”

Section: Discussionsupporting

confidence: 88%

Circulating brain-derived neurotrophic factor, leptin, neuropeptide Y, and their clinical correlates in cystic fibrosis: a cross-sectional study

Nowak

Szczepanik

Trypuć

et al. 2020

aoms

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Introduction: Cystic fibrosis (CF) involves chronic inflammation and decreased pulmonary function, which increase caloric demand. Yet, sufficient energy provision is hindered by reduced appetite and fat malabsorption. Brain-derived neurotrophic factor (BDNF), leptin, and neuropeptide Y (NPY) belong to energy balance-regulating factors. We aimed to assess their concentrations in CF patients in order to search for potential clinical correlates. Material and methods: This was an exploratory, cross-sectional study. Patients' weight and height Z-scores, forced expiratory volume in 1 s (FEV 1 %), exocrine pancreatic status (fecal elastase-1), genotypes, and other characteristics were assessed. Serum concentrations of BDNF, leptin, NPY, IL-6, and TNF-α were measured using ELISA. Results: The study enrolled 56 patients, of whom 29 (52%) were female and 17 (30%) were younger than 16 years. Median (1 st-3 rd quartile) mass Z-score was-0.85 (-1.56-(-0.36)); median FEV 1 was 70.5% (45.0-89.5); 48 (86%) patients had exocrine pancreatic insufficiency and 8 (14%) diabetes. Overall, median concentrations were: BDNF: 33.91 ng/ml (26.40-40.43), leptin: 12.05 ng/ml (8.93-17.77), NPY: 2.86 ng/ml (1.75-4.42). None of these factors correlated with mass Z-score, FEV 1 %, IL-6 or TNF-α. Leptin and NPY correlated negatively (ρ =-0.62, p = 3 × 10-7); BDNF/NPY ratio was associated with leptin (ρ = 0.54, p = 2 × 10-5), BDNF/leptin ratio correlated with NPY (ρ = 0.60, p = 1 × 10-6). In a multivariable regression analysis NPY was weakly, but independently, associated with FEV 1 %, and leptin with age. Conclusions: BDNF and leptin were not associated with weight Z-score or FEV 1 %. Serum NPY concentrations seemed to be lower in CF patients with reduced pulmonary function independently of malnutrition and inflammation.

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Section: Discussionsupporting

confidence: 88%

Circulating brain-derived neurotrophic factor, leptin, neuropeptide Y, and their clinical correlates in cystic fibrosis: a cross-sectional study

Nowak

Szczepanik

Trypuć

et al. 2020

aoms

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“…In accordance with greater leptin gene expression and peptide content in the women fundus, in our study, we noticed significantly higher (more than three times) serum leptin levels in women than in men. Similarly higher hormone levels in the women's blood were described by Ostlund et al ., Kennedy et al ., and Anusha et al …”

Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

“…The level of leptin in the human body depends on anthropometric parameters, such as body mass index (BMI), weight, age, or sex . Literature data show that serum leptin concentration is several times higher in women than in men . Although the causes of this difference between the sexes are not fully established, some authors suggest that differences in the hypothalamic regulation of leptin production or fat distribution in men and women may be its possible explanation.…”

Section: Introductionmentioning

confidence: 99%

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Differences in leptin biosynthesis in the stomach and in serum leptin level between men and women

Kasacka

Piotrowska

Niezgoda

et al. 2019

J of Gastro and Hepatol

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Background and Aim:Although the stomach has been identified as an important source of leptin, the detailed biosynthesis sites of leptin in human gastrointestinal tract have not been fully elucidated. The study objective was to compare leptin distribution and expression in the stomach and its serum level between healthy men and women. Methods: Nineteen subjects (organ donors; 10 men and 9 women) with normal gastric mucosa histology were recruited. Research material contained gastric samples from the cardia, fundus, and pyloric regions. Gastric mucosa leptin content and leptin gene expression were determined by immunohistochemistry and real-time polymerase chain reaction method. Plasma leptin level was measured using ELISA method. Results: In the stomach of healthy adult subjects, leptin-immunoreactive cells were mainly found in the fundus, and the number of immunoreactive cells was higher in women than in men. Leptin-containing cells were less numerous in the cardia and pylorus mucosa. Similarly, leptin gene expression was the highest in the fundus and higher in women than in men. Serum leptin level was higher in women than in men and was found to correlate positively with body mass index and weight in both sexes. A negative correlation between leptin level and age was noted in women, but not in men. Conclusions:The current study is the first to provide evidence for the presence of leptincontaining cells in all segments of the human stomach. The differences in gastric leptin biosynthesis and serum leptin levels between men and women suggest that leptin secretion can be controlled by sex hormones or other unknown factors.

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“…Furthermore, the association between age and adipokines’ levels it is not unambiguous. For example, a cross-sectional study carried out among 226 apparently healthy subjects showed that serum leptin level was not correlated with age in men, whereas in female a significant positive correlation was found [ 53 ]. In another study included 147 patients with T2DM no significant correlation between adiponectin and any clinical parameters, including age, was found [ 54 ], whereas Tingelstad et al [ 55 ] in the study including 331 members of the regular Canadian Armed Forces showed that adiponectin was increasing with increasing age.…”

Section: Discussionmentioning

confidence: 99%

Is There Any Relationship between Plasma 25-Hydroxyvitamin D3, Adipokine Profiles and Excessive Body Weight in Type 2 Diabetic Patients?

Kocot

Dziemidok

Kiełczykowska

et al. 2017

IJERPH

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A growing interest in the role of vitamin D in metabolic diseases led us to study the relationships between 25-hydroxyvitamin D3 (25(OH)D3) and the profiles of selected adipokines in type 2 diabetic (T2DM) patients. The study comprised 92 type 2 diabetics divided into quartiles regarding 25(OH)D3 concentration. Each group was divided into male and female subgroups. All the studied patients had their anthropometric and biochemical parameters determined. Plasma 25-hydroxyvitamin D3 concentration was determined by HPLC, while the selected adipokines (leptin, adiponectin, resistin and visfatin) by ELISA methods. The ratio of leptin to adiponectin (L/A) was calculated for all the patients. In 85.3% of diabetics a full (<20 ng/mL) or moderate (20–30 ng/mL) vitamin D deficit was found. Irrespective of sex, plasma leptin concentration decreased across increasing quartiles of 25(OH)D3 level. In women, 25(OH)D3 was negatively correlated with BMI, leptin level as well as L/A ratio, and positively with adiponectin concentration. In men, 25(OH)D3 was positively correlated with HDL and negatively with systolic blood pressure (SBP), leptin level and L/A ratio. Considering all the patients, there ocurred a significant negative correlation between 25(OH)D3 and SBP, BMI, WHR, TG, leptin and L/A ratio and positive ones between 25(OH)D3 and both adiponectin and HDL. The results of the study support the existence of the relationship among vitamin D, obesity and leptin in type 2 diabetic patients.

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Inter-relationship of serum leptin levels with selected anthropometric parameters among a non-diabetic population: a cross-sectional study

Abstract: A descriptive cross-sectional study, Level V.

Cited by 6 publications

References 20 publications

Circulating brain-derived neurotrophic factor, leptin, neuropeptide Y, and their clinical correlates in cystic fibrosis: a cross-sectional study

Circulating brain-derived neurotrophic factor, leptin, neuropeptide Y, and their clinical correlates in cystic fibrosis: a cross-sectional study

Differences in leptin biosynthesis in the stomach and in serum leptin level between men and women

Is There Any Relationship between Plasma 25-Hydroxyvitamin D3, Adipokine Profiles and Excessive Body Weight in Type 2 Diabetic Patients?

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