Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans

Zhu, Jingwen; Sun, Qi; Zong, Geng; Si, Yuan; Liu, Chen; Qi, Qibin; Ye, Xingwang; Sun, Liang; Lin, Xu

doi:10.1194/jlr.p027516

Cited by 18 publications

(17 citation statements)

References 43 publications

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“…This study found that in the Japanese population, the C-allele of FADS1 -rs174547 was associated with increased TG and lower HDL-C concentrations, but in the Mongolian population it was associated with lower LDL-C concentrations [32]. Similar associations were reported in the Northern and Southern Chinese populations; the C-allele of rs174550 was associated with high TC levels in Beijing participants, but this allele was associated with lower HDL-C in Shanghai residents [33]. A possible explanation for the variability in lipid-gene associations could be due to differences in dietary fat intake between these two populations [19, 32, 33].…”

Section: Discussionsupporting

confidence: 60%

“…Similar associations were reported in the Northern and Southern Chinese populations; the C-allele of rs174550 was associated with high TC levels in Beijing participants, but this allele was associated with lower HDL-C in Shanghai residents [33]. A possible explanation for the variability in lipid-gene associations could be due to differences in dietary fat intake between these two populations [19, 32, 33]. Moreover, the different LD patterns across populations may explain the different associations found in lipid traits [19, 30].…”

Section: Discussionsupporting

confidence: 57%

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Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study

Vázquez-Vidal¹,

Voruganti²,

Hannon³

et al. 2018

Lifestyle Genomics

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Background: Recent genome-wide association studies in the Mexican population have identified several genetic loci associated with blood lipid levels in adults. However, studies focusing on the fatty acid desaturase (FADS) gene cluster have been understudied in this population, even though it seems associated with lipid profiles in other ethnicities. The aim of this study was to test associations between single nucleotide polymorphisms (SNPs) in the FADS cluster (rs174546, rs1535, rs174548, rs174550, rs174450, and rs174618) and serum lipid profiles in young Mexicans. Methods: Anthropometrics, serum lipid profiles, and FADS SNPs were measured in 998 subjects in the UP-AMIGOS cohort study. Genotype-phenotype (total cholesterol [TC], triglyceride [TG], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], and very-low-density lipoprotein [VLDL]) associations were assessed using PLINK adjusted for sex, age, and body mass index (BMI). Results: Among 6 FADS SNPs, we found that carriers of the C-allele of the FADS1-rs174546 showed a significant association with lower TG concentrations (β = –12.6 mg/dL, p = 0.009) and lower VLDL concentrations (β = –2.52 mg/dL, p = 0.005). We found that rs174546, rs1535, and rs174550 were in high linkage disequilibrium (r² > 0.80). There were no significant associations between rs174550, rs174548, and rs174618 and lipid profiles. Conclusion: A genetic variant in the FADS1 (rs174546) gene is a major contributor of plasma TG and VLDL concentrations in healthy young Mexicans.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionsupporting

confidence: 57%

Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study

Vázquez-Vidal¹,

Voruganti²,

Hannon³

et al. 2018

Lifestyle Genomics

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“…D5D and D6D activities were estimated by product-to-precursor ratios of 20:4n-6/20:3n-6 and 18:3n-6/18:2n-6, respectively. For validation of estimated D5D and D6D activities measured in serum, we selected an intron variant of FADS1 gene (rs174550) that is a known glucose raising variant and is strongly associated with the proportions of various n-6 fatty acids in erythrocytes [29,30].…”

Section: Calculationsmentioning

confidence: 99%

Longitudinal associations of serum fatty acid composition with type 2 diabetes risk and markers of insulin secretion and sensitivity in the Finnish Diabetes Prevention Study

et al. 2015

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“…Этот фермент катализирует превращение жирных кислот путем введения двойных связей в насыщен-ные жирные кислоты. Показано, что маркер rs174546 гена FADS1 ассоциирован с пониженным уровнем триглицеридов, что подтверждает результат нашего исследования [26]. Рядом авторов было показано, что особенности метаболизма и питания опосредо-ваны полиморфными вариантами гена FADS1, которые способны изменять содержание полиненасыщенных жирных кислот в крови и тканях, что влияет на био-логические реакции и состояние здоровья [26].…”

Section: Discussionunclassified

Association of obesity susceptibility gene variants with metabolic syndrome in women

et al. 2017

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Aim. The aim of the study was a replicative analysis of the association of polymorphic variants of genes associated with obesity revealed by results of wide-genomic studies (GWAS) with the development of a cluster of metabolic syndrome risk parameters in women of Bashkir and Tatar ethnicity. The polymorphic markers of the following genes were analyzed: SEC16B, FADS1, KCTD15, MAF, MAP2K5, NEGR1, BDNF, TMEM18. Materials and methods. The study involved 243 women with metabolic syndrome and 298 women without the metabolic syndrome. Amplification of DNA fragments was performed using real-time PCR and TaqMan technique. Results. We found the association the metabolic syndrome with genetic markers of genes MAF and TMEM18 from Tatar. Protective informative marker of the metabolic syndrome among Tatar and Bashkir was the TT haplotype TMEM18 gene (rs2860323 and rs6548238) (р=0.005 and р=0.001, respectively). We identified the association marker rs2241423 MAP2K5 gene with the level of waist circumference (p=0.003) and with the level of cholesterol (p=0.014), the marker rs11084753 KCTD15 gene with glucose levels after exercise (p=0.002), the level of triglycerides (p=0.003) and HDL (p=0.0008) among Tatar women. We identified the association rs2241423 MAP2K5 gene marker to glycated hemoglobin level (p=0.002) and a marker gene rs174550 FADS1 with triglyceride levels (p=0.02) among Bashkir women. Conclusion. It can be assumed that the polymorphic variants FADS1, KCTD15, MAF, MAP2K5, TMEM18 genes are an important part of the genetic structure of predisposition to metabolic syndrome and/or to a cluster of clinical and biochemical indicators of the risk of metabolic syndrome.

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Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans

Cited by 18 publications

References 43 publications

Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study

Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study

Longitudinal associations of serum fatty acid composition with type 2 diabetes risk and markers of insulin secretion and sensitivity in the Finnish Diabetes Prevention Study

Association of obesity susceptibility gene variants with metabolic syndrome in women

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