Interaction between an ATP-Binding Cassette A1 (&lt;i&gt;ABCA1&lt;/i&gt;) Variant and Egg Consumption for the Risk of Ischemic Stroke and Carotid Atherosclerosis: a Family-Based Study in the Chinese Population

Song, Jing; Jiang, Xia; Cao, Yaying; Juan, Juan; Wu, Tao; Hu, Yonghua

doi:10.5551/jat.46615

Cited by 10 publications

(9 citation statements)

References 61 publications

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“…The association between egg consumption and risk of stroke also appears complicated, from no association to lowering risk [43,62,63,68,69] or increasing risk [70,90]. A higher risk was associated with hemorrhagic stroke more than with ischemic stroke [68].…”

Section: Stroke and Hypertensionmentioning

confidence: 99%

Nutritional Viewpoints on Eggs and Cholesterol

Sugano

Matsuoka²

2021

Foods

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Although most current epidemiologic studies indicate no significant association between consuming one egg daily and blood cholesterol levels and cardiovascular risk, arguments still persist with a positive association. Since the diet is one of the most influential factors for this association, we illustrate characteristic features in Japanese people whose dietary pattern is distinct from that, for example, the US (United States) population. Available epidemiologic studies in healthy Japanese people show no association between consumption of one egg daily and blood cholesterol level, consistent with those observed in the US population. However, when consumption of major nutrients and food sources of cholesterol are compared to the US population, Japanese people may have an extra-reserve against the influence of eggs on cardiovascular risk markers, despite consuming relatively more eggs. Further discussion on the influence of nutrients contained in the egg and dietary pattern, including interaction with gut microbes, is necessary. In addition, special consideration at the personalized level is needed for judgment regarding dietary cholesterol not only for hypercholesterolemic patients but for hyper-responsive healthy persons. Although randomized controlled trials with long-term follow-up are required to evaluate the association between consumption of eggs and human health, available information, at least from the nutritional viewpoint, suggests that egg is a healthy and cost-efficient food worldwide.

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Section: Stroke and Hypertensionmentioning

confidence: 99%

Nutritional Viewpoints on Eggs and Cholesterol

Sugano

Matsuoka²

2021

Foods

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“…DNA was extracted using LabTurbo 496-Standard System (TAIGEN Bioscience Corporation, Taiwan, China). In addition, the purity and concentration of DNA were measured using ultraviolet spectrophotometry [ 29 ]. Furthermore, the genomic DNA sample was genotyped with the time of flight mass spectrum using MassARRAY ® System (Agena Bioscience, San Diego, CA, USA).…”

Section: Methodsmentioning

confidence: 99%

Carotid Intima-Media Thickness, Genetic Risk, and Ischemic Stroke: A Family-Based Study in Rural China

Wang

et al. 2020

IJERPH

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Background: Carotid intima-media thickness (cIMT) has been associated with an elevated risk of ischemic stroke (IS) in several studies, but the results are inconsistent. We investigated whether the association between cIMT and IS varied across different IS subtypes, and further assessed gene–cIMT interactions’ association with IS risk. Methods: A total of 1048 IS cases (795 large-artery atherosclerosis (LAA) cases, 103 small-vessel occlusion (SVO) cases, and 150 other subtypes) and 2696 IS-free controls across 2179 families were included in the analysis. Self-reported IS cases were confirmed through medical records’ review and head imaging by computed tomography and/or magnetic resonance imaging. The mean values of the common cIMT obtained in bilateral distal and proximal carotid artery segments were used. The genotype information of rs2910164 polymorphism in microRNA-146a (miR-146a) was also collected. Results: We found that cIMT was significantly associated with a higher risk of IS and LAA subtype but not SVO subtype in the multivariate-adjusted models. The odds ratio (OR) and 95% confidence interval (CI) in the highest quartile versus the lowest quartile of cIMT was 2.48 (1.92–3.20) for IS and 2.75 (2.08–3.64) for LAA (both p trend <0.001). The results also showed that there was a significant interaction between cIMT and rs2910164 genotype with the risk of IS (p interaction = 0.03) and LAA (p interaction = 0.02). The associations of cIMT with IS and LAA were strengthened among participants carried rs2910164_GG genotype compared with those with rs2910164_CC genotype. Conclusions: Our results indicate that higher cIMT levels were significantly associated with IS and LAA subtype but not SVO subtype, and the relations were modified by rs2910164 polymorphism in miR-146a.

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“…Within the food and food items categories, the FISSIC found a signi cant (p=0.006) interaction between the egg intake and ABCA1 variant (rs2066715) 59 . In the same study, a signi cant interaction between vegetable intake and the PON1 rs662 variant on the risk of stroke was found.…”

Section: Gene-diet Interactions and Coronary Heart Diseasementioning

confidence: 97%

“…After screening titles and abstracts, we screened the full texts of 177 articles, of which 54 met the inclusion criteria and were included in the nal analysis (Figure 1). Of the included articles, 13 evaluated MI 16,28-39 , 17 evaluated CHD [11][12][13][40][41][42][43][44][45][46][47][48][49][50][51][52][53] , ten evaluated stroke 14,[54][55][56][57][58][59][60][61][62] , four examined composite CVD 15,[63][64][65] , and ten evaluated at least two of the following outcomes: CHD, MI, CVD or stroke 6,17,66-73 . The de nition of all outcomes can be found in Table S2.…”

Section: Study Identi Cation and Selectionmentioning

confidence: 99%

Gene-diet interactions and cardiovascular diseases: A systematic review of observational and clinical trials

Roa‐Díaz

Teuscher

Gamba

et al. 2022

Preprint

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Background: Both genetic background and diet are important determinants of cardiovascular diseases (CVD). Understanding gene-diet interactions could help improve CVD prevention and prognosis. We aimed to summarise the evidence on gene-diet interactions and CVD outcomes systematically. Methods: We searched MEDLINE® via Ovid, Embase, PubMed®, and The Cochrane Library for relevant studies published until May 7th 2021. We considered for inclusion cross-sectional, case-control, prospective cohort, nested case-control, and case-cohort studies as well as randomised controlled trials that evaluated the interaction between genetic variants and/or genetic risk scores and food or diet intake on the risk of related outcomes, including myocardial infarction, coronary heart disease (CHD), stroke and CVD as a composite outcome. The PROSPERO protocol registration code is CRD42019147031.Results and discussion: We included 54 articles based on data from 29 studies; six articles involved multiple studies, and three did not report details of their source population. The median sample size of the articles was 2562 participants. Of the 54 articles, 19 (35.2%) were qualified as high quality, while the rest were intermediate or poor. Eight (14.8%) articles adjusted for multiple comparisons, four (7.0%) attempted to replicate the findings, 15 (27.7%) were based on Han-Chinese ethnicity, and 28 (52%) did not present Minor Allele Frequency. Forty-nine different dietary exposures and 47 different genetic factors were investigated, with alcohol intake and ADH1C variants being the most examined. Of 249 investigated diet-gene interaction tests, 47 (18.9%) were statistically significant, including CETP-TaqIB and ADH1C variants, which interacted with alcohol intake on CHD risk. However, interactions effects were significant only in some articles and did not agree on the direction of effects. Moreover, most of the studies that reported significant interactions lacked replication. Overall, the evidence on gene-diet interactions on CVD is limited, and lack correction for multiple testing, replication and sample size consideration.

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Interaction between an ATP-Binding Cassette A1 (<i>ABCA1</i>) Variant and Egg Consumption for the Risk of Ischemic Stroke and Carotid Atherosclerosis: a Family-Based Study in the Chinese Population

Cited by 10 publications

References 61 publications

Nutritional Viewpoints on Eggs and Cholesterol

Nutritional Viewpoints on Eggs and Cholesterol

Carotid Intima-Media Thickness, Genetic Risk, and Ischemic Stroke: A Family-Based Study in Rural China

Gene-diet interactions and cardiovascular diseases: A systematic review of observational and clinical trials

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