Interaction Between Prolactin, LH, Neurohypophysial Hormones and Hysterectomy on Luteal Function in Rats1

Hausler, C. L.; Malven, P.V.

doi:10.1093/biolreprod/5.3.262

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…These data confirm previous reports on progesterone concentrations in intact and acutely hysterectomized pseudopregnant animals (20,21). Pepe and Rothchild (20), however, reported that serum progesterone concentrations in long-term hysterectomized rats were higher than those in intact animals.…”

Section: Discussionsupporting

confidence: 91%

Effect of Hysterectomy on Serum Luteinizing Hormone Concentrations and on Corpus Luteum Function in the Rat

Greef

Dullaart

Zeilmaker³

1976

Endocrinology

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Serum progesterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) concentrations were estimated in intact and hysterectomized pseudopregnant rats. Progesterone concentrations increased significantly from day 2 of pseudopregnancy (PSP) onwards, and a plateau was reached on days 4 and 5. No significant differences in progesterone concentrations between intact and long-term hysterectomized animals were observed until day 10 of PSP. In the intact rats, progesterone concentrations decreased after day 8, but in the hysterectomized rats they remained elevated until days 18-20 of PSP. No differences between FSH concentrations in intact and hysterectomized rats were found. In hysterectomized rats, however, LH concentrations were significantly lower than those in the intact rats on days 2-7 of PSP. When hysterectomy was performed on day 2 of PSP (acute hysterectomy) lower LH concentrations were also found in the hysterectomized animals compared with sham-operated animals. No differences in progesterone concentrations were found between sham-operated controls and acutely hysterectomized animals on days 3-8 of PSP. It was found that LH concentrations in ovariectomized long-term hysterectomized rats were lower than those in ovariectomized, but otherwise intact, animals. In contrast to its effect on tonic LH secretion, long-term hysterectomy had no influence on the surge of LH during the afternoon of proestrus. In both intact and long-term hysterectomized rats the duration of PSP was not significantly altered after transplantation of an ovary under the kidney capsule and the removal of the ovaries in situ. It is concluded that hysterectomy leads to a decreased LH secretion by the pituitary gland, but has no influence on the maximal progesterone concentrations during PSP. The significance of these findings, particularly with regard to the prolongation of PSP after hysterectomy, is discussed.

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Section: Discussionsupporting

confidence: 91%

Effect of Hysterectomy on Serum Luteinizing Hormone Concentrations and on Corpus Luteum Function in the Rat

Greef

Dullaart

Zeilmaker³

1976

Endocrinology

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“…That prolactin can be antigonadal or stimulate sex-related structures (Sundararaj & Nayyar, 1965;de Vlaming & Sundararaj, 1972) in fishes may also be related to a prolactin-adrenal steroid interaction. Evidence also exists for a temporal interaction between prolactin and LH in mammals (Hausler & Malven, 1971 ;Johnson, 1974). This is interesting in the light of the temporal effects of gonadotropin reported here.…”

supporting

confidence: 66%

Diurnal variations in pituitary gonadotropin content and in gonadal response to exogenous gonadotropin and prolactin in Notemigonus crysoleucas

Vlaming

Vodicnik

1977

Journal of Fish Biology

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Diurnal variations in pituitary gonadotropin content were determined in the golden shiner, Notemigonus crysoleucas. In fish maintained on a 15.5L/85D-l5" C regime, a pronounced circadian variation in pituitary gonadotropin potency was observed, the gonadotropin content being minimal early and maximal late during the light phase. Little temporal variation was seen in fish exposed to a 9L/15D-lS0 C regime. The effects of gonadotropin and prolactin treatment on gonadal activity in N. crysoleucas were also investigated. Salmon gonadotropin was effective in stimulating an increased rate of gonadal development when given early during the light phase in fish maintained on a 15.5L/85D-l5" C regime; injections of gonadotropin given late in the light phase failed to accelerate gonadal growth. Regardless of time of injection, ovine luteinizing hormone accelerated gonadal growth in fish maintained on a 9L/15D-1S0 C regime. Ovine prolactin retarded gonadal development in fish exposed to a 15*5L/8.5D-24" C regime, independent of injection time. In fish maintained on a 15.5L/8.5D-15" C regime, injections of prolactin given early, but not late, during the light phase repressed gonadal maturation. These data show that under certain photoperiod-temperature conditions there is a temporal aspect to responsiveness to exogenous hormone treatment.

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“…These have indicated that prolactin causes an inhibi-tion of 20 u-hydroxysteroid dehydrogenase, a facilitation of cholesterol turnover into progesterone and an increase of fatty acid synthesis and cholesterol esterification [A rm strong, 1968: A rm strong et al, 1970], All these functions may be responsible for the luteotrophic effect of prolactin [M a cd o n a ld et al, 1971], However, the same hormone has also been shown to be attributable to the luteolytic effect [M alven andHoge, 1971: W uttge et al. 1971: G ra n d iso n and M eites, 1972], From different studies it appears that the effects of prolactin together with LH on corpora lutea depend on the history of the particular set of corpora lutea studied, and not only are the amount and kind of hormone administered important but also the sequence of hormone injection.…”

Section: Introductionmentioning

confidence: 99%

Distribution of <sup>125</sup>I-Prolactin in Mice and Rats. Studies with Whole-Body and Microautoradiography

1974

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The distribution of ¹²⁵I-labeled ovine prolactin was studied in mice and rats after an intravenous injection by using whole-body and microautoradiography. In the whole-body autoradiography the labeled hormone rapidly accumulated in liver and kidney, but additionally some labeling was noted in the ventral prostate, seminal vesicles and mammary glands. In microautoradiography the grains were localized almost exclusively in the proximal tubular cells of the kidney. In the liver the labeling was more diffuse over both the parenhymal and the KupfTer cells. In the ovary the labeling was weak and mainly localized over the corpus luteum. Only minor differences were encountered in the intensity of labeling during the sexual cycle, pregnancy and lactation. The mammary epithelium showed some labeling during pregnancy and lactation. In the testis the grains were localized around the Leydig cells with no indication of tubular distribution. The ventral prostate showed a clear labeling of the epithelium. With increasing time after the injections the grains were rapidly localized toward the prostatic acinar lumen. Only a weak labeling of the preputial glands and seminal vesicles was observed. The role of prolactin as a synergist in the hormonal control of a variety of target organs was discussed.

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Interaction Between Prolactin, LH, Neurohypophysial Hormones and Hysterectomy on Luteal Function in Rats1

Cited by 6 publications

References 22 publications

Effect of Hysterectomy on Serum Luteinizing Hormone Concentrations and on Corpus Luteum Function in the Rat

Effect of Hysterectomy on Serum Luteinizing Hormone Concentrations and on Corpus Luteum Function in the Rat

Diurnal variations in pituitary gonadotropin content and in gonadal response to exogenous gonadotropin and prolactin in Notemigonus crysoleucas

Distribution of <sup>125</sup>I-Prolactin in Mice and Rats. Studies with Whole-Body and Microautoradiography

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