Interaction of an antibiotic – Norfloxacin with lipid membrane

Suklabaidya, Sudip; Debnath, Pintu; Dey, Bapi; Bhattacharjee, D.; Hussain, Syed Arshad

doi:10.1016/j.matpr.2017.09.244

Cited by 4 publications

(1 citation statement)

References 27 publications

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“…Previous studies have shown evidences of NOR interaction with the lipid phase of model membranes, such as protection of NOR photodegradation when encapsulated in liposomes [8] or the increase in membrane fluidity in the presence of NOR [32]. However, the partition coefficient of NOR is low (0.46) [33], probably given by its amphoteric behavior at physiologic pH.…”

Section: Discussionmentioning

confidence: 99%

Hybrid Pectin-Liposome Formulation against Multi-Resistant Bacterial Strains

et al. 2020

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This work describes the development of a gastroresistant antimicrobial formulation composed of two carriers, pectin and liposomes, intended to improve the efficiency of norfloxacin (NOR) against multi-resistant bacterial strains. The formulations showed physicochemical stability for 180 days (4 °C) in terms of size, polydispersity, and zeta potential of the vesicles, prolonging the in vitro release of NOR for 11 h. The hybrid nanocarriers improved the in vitro antimicrobial activity against different multidrug-resistant bacterial strains, such as Salmonella sp., Pseudomonasaeruginosa, E. coli and Campylobacterjejuni, in comparison to commercial NOR and liposomal suspensions. The in vivo toxicity assay in chicken embryos revealed that the hybrid systems were not toxic in any of the different parameters analyzed, a result also corroborated by the analyses of biochemical biomarkers of the chicken-embryos liver function.

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Section: Discussionmentioning

confidence: 99%