Interaction of Curcumin and Bixin with β-Cyclodextrin: Complexation Methods, Stability, and Applications in Food

Marcolino, Vanessa Aparecida; Zanin, Gisella Maria; Durrant, Lúcia Regina; Benassi, Marta de Toledo; Matioli, Graciette

doi:10.1021/jf104223k

Cited by 180 publications

(116 citation statements)

References 20 publications

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“…This level of drug loading was likely achieved because the presence of a CD layer shell at the interface of the MNP core and F68 polymer chains may prevent the diffusion of CUR. 21,45,46 Figure 1E demonstrates the release profile of CUR from MNP-CUR under in vitro conditions. A slow and sustained release of CUR from MNP-CUR was noticed throughout the study (for 28 days).…”

Section: Resultsmentioning

confidence: 99%

Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applications

Yallapu¹,

Othman²,

Curtis³

et al. 2012

IJN

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Background:The next generation magnetic nanoparticles (MNPs) with theranostic applications have attracted significant attention and will greatly improve nanomedicine in cancer therapeutics. Such novel MNP formulations must have ultra-low particle size, high inherent magnetic properties, effective imaging, drug targeting, and drug delivery properties. To achieve these characteristic properties, a curcumin-loaded MNP (MNP-CUR) formulation was developed. Methods: MNPs were prepared by chemical precipitation method and loaded with curcumin (CUR) using diffusion method. The physicochemical properties of MNP-CUR were characterized using dynamic light scattering, transmission electron microscopy, and spectroscopy. The internalization of MNP-CUR was achieved after 6 hours incubation with MDA-MB-231 breast cancer cells. The anticancer potential was evaluated by a tetrazolium-based dye and colony formation assays. Further, to prove MNP-CUR results in superior therapeutic effects over CUR, the mitochondrial membrane potential integrity and reactive oxygen species generation were determined. Magnetic resonance imaging capability and magnetic targeting property were also evaluated. Results: MNP-CUR exhibited individual particle grain size of ∼9 nm and hydrodynamic average aggregative particle size of ∼123 nm. Internalized MNP-CUR showed a preferential uptake in MDA-MB-231 cells in a concentration-dependent manner and demonstrated accumulation throughout the cell, which indicates that particles are not attached on the cell surface but internalized through endocytosis. MNP-CUR displayed strong anticancer properties compared to free CUR. MNP-CUR also amplified loss of potential integrity and generation of reactive oxygen species upon treatment compared to free CUR. Furthermore, MNP-CUR exhibited superior magnetic resonance imaging characteristics and significantly increased the targeting capability of CUR. Conclusion: MNP-CUR exhibits potent anticancer activity along with imaging and magnetic targeting capabilities. This approach can be extended to preclinical and clinical use and may have importance in cancer treatment and cancer imaging in the future. Further, if these nanoparticles can functionalize with antibody/ligands, they will serve as novel platforms for multiple biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applications

Yallapu¹,

Othman²,

Curtis³

et al. 2012

IJN

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“…3 The poor solubility of curcumin limits its absorption and results in low bioavailability. 4 Many new drug delivery systems have been developed to increase the aqueous solubility and the bioavailability of curcumin by using a variety of drug carriers, including liposomes, 5 phospholipid, 6 cyclodextrin, 7 chitosan nanoparticles, 8 protein nanoparticles such as silk fibroin, 9 zein, 10 and bovine serum albumin, 11 synthetic polymer nanoparticles such as PLGA, 12,13 PCL-PEG-PCL triblock copolymer, 14 and polymer nanofibers such as polyvinyl alcohol (PVA), 15 poly-(ε-caprolactone), 16 and zein. 17 Another approach for improving the bioavailability of poorly water-soluble drugs is the micronization of these drugs.…”

Section: Introductionmentioning

confidence: 99%

Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2

Zhao¹,

Xie²,

Li³

et al. 2015

IJN

138

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In order to enhance the bioavailability of poorly water-soluble curcumin, solution-enhanced dispersion by supercritical carbon dioxide (CO 2 ) (SEDS) was employed to prepare curcumin nanoparticles for the first time. A 2 4 full factorial experiment was designed to determine optimal processing parameters and their influence on the size of the curcumin nanoparticles. Particle size was demonstrated to increase with increased temperature or flow rate of the solution, or with decreased precipitation pressure, under processing conditions with different parameters considered. The single effect of the concentration of the solution on particle size was not significant. Curcumin nanoparticles with a spherical shape and the smallest mean particle size of 325 nm were obtained when the following optimal processing conditions were adopted: P =20 MPa, T =35°C, flow rate of solution =0.5 mL·min −1 , concentration of solution =0.5%. Fourier transform infrared (FTIR) spectroscopy measurement revealed that the chemical composition of curcumin basically remained unchanged. Nevertheless, X-ray powder diffraction (XRPD) and thermal analysis indicated that the crystalline state of the original curcumin decreased after the SEDS process. The solubility and dissolution rate of the curcumin nanoparticles were found to be higher than that of the original curcumin powder (approximately 1.4 μg/mL vs 0.2 μg/mL in 180 minutes). This study revealed that supercritical CO 2 technologies had a great potential in fabricating nanoparticles and improving the bioavailability of poorly water-soluble drugs.

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“…Nowadays, these dyes are largely used as substitutes for synthetic dyes in the food and cosmetic industries (Giuliano et al 2003;Dias et al 2011;Marcolino et al 2011;Mala et al 2015) or as histological plant staining (Akinloye et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Somatic Embryogenesis in Annatto (Bixa orellana L.)

Matos

Koehler

Faria

et al. 2016

Somatic Embryogenesis: Fundamental Aspects and Applications

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Our research group has pioneered the work on somatic embryogenesis of Bixa orellana (annatto), and since then we have directed efforts in understanding several aspects of this morphogenic pathway in annatto. Here, we present a synthetic description of such works, emphasizing anatomical analyzes and the characterization of the cellular alterations that occur in the process, and the association of the SERK gene expression and somatic embryogenesis. These results are unprecedented and contribute to a better understanding of the processes involving

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Interaction of Curcumin and Bixin with β-Cyclodextrin: Complexation Methods, Stability, and Applications in Food

Cited by 180 publications

References 20 publications

Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applications

Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applications

Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2

Somatic Embryogenesis in Annatto (Bixa orellana L.)

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