Interaction of haloperidol with human serum albumin and effect of metal ions on the binding

Ruthenium(II) Complexes of Isothiazole Ligands: Crystal Structure, HSA/DNA Interactions, Cytotoxic Activity and Molecular Docking Simulations

“…The calculated K SV , k q , K , and n values are given in Table . As seen in Table , the quenching constants (>10 12 m −1 s −1 ) are higher than diverse kinds of quenchers for biopolymers fluorescence (10 10 m −1 s −1 ), suggesting that the interaction of the ligands and complexes with the albumins takes place via a static quenching mechanism, which indicates the formation of a new conjugate between each complex and HSA …”

“…As seen in Table 4, the quenching constants (> 10 12 m À 1 s À 1 ) are higher than diverse kinds of quenchers for biopolymers fluorescence (10 10 m À 1 s À 1 ), suggesting that the interaction of the ligands and complexes with the albumins takes place via a static quenching mechanism, which indicates the formation of a new conjugate between each complex and HSA. [38] The calculated value of n is around one for all the compounds, indicating the existence of just a single binding site in HSA for all the compounds. From the values of K SV and K, it is inferred that complex 3 interacts with HSA more strongly than the rest of the compounds.…”

Thermodynamic investigation of the interaction between ionic liquid functionalized gold nanoparticles and human serum albumin for selective determination of glutamine

“…Several research work have been reported for the characteristic sign of the thermodynamic parameters related to interaction of IL-AuNPs with HSA. 14,15 Reshma et al 32 showed binding of HSA to CDs and found binding constant 5.04 Â 10 À4 M, J. D. Berić et al 44 studied effect of metal ions on haloperidol and HSA and observed binding constant 7.94 Â 10 3 dm À3 mol À1 . However, our system shows higher binding constant towards HSA and strong interaction with 2.6 Â 10 4 and strong binding with 3.10 Â 10 4 .…”

Synthesis, characterization, HSA/DNA interactions and antitumor activity of new [Ru(η6-p-cymene)Cl2(L)] complexes

“…Details of Autodock 4.2.6 docking procedures are described elsewhere [39,67]. Since ruthenium is not included in the AutoDock parameter file, extended parameter file including Ru(II) parameters was used [68].…”

“…quenchers for biopolymers fluorescence (10 10 M −1 s −1 ), suggesting that the interaction of the ligands and complexes with the albumins takes place via a static quenching mechanism, which indicates the formation of a new conjugate between each complex and HSA[67].Using the equation (Eq. (3)) (see ESI), the values of K (association binding constant) and n (number of binding sites per albumin) for the ligands 1-3 and complexes 4-6 were obtained from the intercept and slope of the plots of log (F 0 − F)/F versus log [Q] (Figs.S22 and S23, ESI).The values of the binding constant, K and those of n are given in Table3.…”