Interaction of lithium and sleep deprivation on memory performance and anxiety-like behavior in male Wistar rats

Torabi, Z.; Rezaie, Maede; Aramvash, Asieh; Nasiri-Khalili, Mohammad-Ali; Nasehi, Mohammad; Abedi, Behnaz; Vaseghi, Salar

doi:10.1016/j.bbr.2022.113890

Cited by 9 publications

(2 citation statements)

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“…Brain Derived Neurotrophic Factor, a neurotrophin that may have neuroprotective properties, shows reduced serum concentration in patients with AD 3–5 and has been studied extensively in this population 6–8 . There is consistent evidence in animal studies that lithium increases levels of BDNF in the brain 9–13 . In several animal models, lithium has been shown to mediate this process by stimulating synthesis and release of BDNF, 9,14–17 but there has been limited investigation of lithium's effects on BDNF in clinical trials with human subjects.…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8] There is consistent evidence in animal studies that lithium increases levels of BDNF in the brain. [9][10][11][12][13] In several animal models, lithium has been shown to mediate this process by stimulating synthesis and release of BDNF, 9,[14][15][16][17] but there has been limited investigation of lithium's effects on BDNF in clinical trials with human subjects. DeSousa and colleagues 18 found increased serum BDNF levels in patients with acute bipolar mania after 4 weeks of treatment with lithium.…”

Section: Introductionmentioning

confidence: 99%

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Effects of lithium on serum Brain‐Derived Neurotrophic Factor in Alzheimer’s patients with agitation

Deliyannides,

Graff,

Niño

et al. 2023

Int J Geriat Psychiatry

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BackgroundThere is ample evidence in animal models that lithium increases Brain‐Derived Neurotrophic Factor (BDNF) with supporting evidence in human studies. Little is known, however, about the effects of lithium on BDNF in Alzheimer's Dementia (AD). In one study of patients with Mild Cognitive Impairment, serum BDNF increased after treatment with lithium. These patients also showed mild improvement in cognitive function.ObjectivesTo evaluate low‐dose lithium treatment of agitation in Alzheimer's disease (AD).MethodWe measured levels of BDNF in patients treated with lithium prior to and after a 12‐week randomized placebo‐controlled trial.ResultsBDNF levels did not change significantly and were not associated with improvement in overall neuropsychiatric symptoms or in cognitive function.ConclusionsMore research is needed to understand the potential effects of lithium on BDNF in AD including whether its use might be dependent on the stage of cognitive decline and dementia.

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