Interaction of lysozyme with gold nanorods: conformation and activity investigations

Conformation and activity of lysozyme on binding to two types of gold nanorods: A comparative study

“…Recently Moghadam et al showed that under the specified experimental condition (i.e. pH 6.2), CTAB has no role in the interaction results and changes in the secondary structure of lysozyme could be attributed to the presence of gold nanorods [18]. As an overall conclusion in this section, lysozyme still retains its native structure in the vicinity of rod-shaped gold nanostructures, with lesser degree of conformational change in the case of gold nanorice.…”

“…Simultaneously, Moghadam et al reported the interaction between lysozyme and gold nanorods, showing that the enzyme retains high fraction of its native structure and exhibits proper catalytic activity upon the adsorption [18]. Herein, we present the kinetics and conformation of lysozyme in the presence of gold nanorods with different lengths and surface chemistry.…”

Heat induced aggregation of gold nanorods for rapid visual detection of lysozyme

“…Previous reports have shown that GNRs dispersed in deionized water are capable of resisting at high temperatures. However, after two hours of heat treatment length of the nanorods start decreasing due to Ostwald ripening effect [12,34]. Amongst the heated samples shown in Fig.…”

“…Therefore, shortening of the average length of GNRs might be responsible for perturbation of morphology; giving rise to formation of spherical-like aggregates at higher temperatures. For untreated GNRs, such phenomenon does not happen in a similar fashion, since the rod morphology of nanostructures is supported by saturated cationic surfactant [12].…”

“…With well-known structure, function, dynamics and physico-chemical properties [11][12][13][14], it is an important defense molecule of the innate immune system, mediating protection against microbial invasion. Being a low molecular weight protein, it can be filtered easily through glomerulus and reabsorbed by the proximal tubular cells via the megalin receptor [15][16][17].…”