Interaction of metal oxide nanoparticles with lung surfactant protein A

Schulze, Christine; Schaefer, Ulrich F.; Ruge, Christian A.; Wohlleben, Wendel; Lehr, Claus‐Michael

doi:10.1016/j.ejpb.2010.10.013

Cited by 80 publications

(62 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, inhaled NPs are first exposed to lung fluid [53], which has a very different composition than blood plasma [54]. A first PC, rich in surfactant proteins and other biomolecules, is generated around the NPs in the lungs [55][56][57]. This is then displaced by a new corona as soon as the NPs enter the bloodstream [9].…”

Section: Composition Of the Pcmentioning

confidence: 99%

The Impact of Nanoparticle Protein Corona on Cytotoxicity, Immunotoxicity and Target Drug Delivery

Corbo

Molinaro

Parodi

et al. 2015

Nanomedicine (Lond.)

556

443

View full text Add to dashboard Cite

In a perfect sequence of events, nanoparticles (NPs) are injected into the bloodstream where they circulate until they reach the target tissue. The ligand on the NP surface recognizes its specific receptor expressed on the target tissue and the drug is released in a controlled manner. However, once injected in a physiological environment, NPs interact with biological components and are surrounded by a protein corona (PC). This can trigger an immune response and affect NP toxicity and targeting capabilities. In this review, we provide a survey of recent findings on the NP–PC interactions and discuss how the PC can be used to modulate both cytotoxicity and the immune response as well as to improve the efficacy of targeted delivery of nanocarriers.

show abstract

Section: Composition Of the Pcmentioning

confidence: 99%

The Impact of Nanoparticle Protein Corona on Cytotoxicity, Immunotoxicity and Target Drug Delivery

Corbo

Molinaro

Parodi

et al. 2015

Nanomedicine (Lond.)

556

443

View full text Add to dashboard Cite

show abstract

“…Interestingly, three variants of the same material (cerium dioxide nanoparticles) revealed different adsorption patterns despite the materials being nominally identical and indistinguishable in electron microscopy images [46]. This suggests that the biomolecule corona composition, or the details of the bio-nano interface, could be a very sensitive tool to distinguish subtle material differences and to predict biological impacts, once correlations between adsorbed biomolecules and signalling or other effects are confirmed.…”

Section: Effect Of Adsorption On Biomoleculesmentioning

confidence: 96%

“…A study of the interaction of nanoparticles with surfactant protein A (SP-A), a significant protein component of alveolar lining fluid, found different particle-protein interactions for each of eight different nanoparticles [46]. Interestingly, three variants of the same material (cerium dioxide nanoparticles) revealed different adsorption patterns despite the materials being nominally identical and indistinguishable in electron microscopy images [46].…”

Section: Effect Of Adsorption On Biomoleculesmentioning

confidence: 99%

The bio-nano-interface in predicting nanoparticle fate and behaviour in living organisms: towards grouping and categorising nanomaterials and ensuring nanosafety by design

et al. 2013

View full text Add to dashboard Cite

Abstract:In biological media, nanoparticles acquire a coating of biomolecules (proteins, lipids, polysaccharides) from their surroundings, which reduces their surface energy and confers a biological identity to the particles. This adsorbed layer is the interface between the nanomaterial and living systems and therefore plays a significant role in determining the fate and behaviour of the nanoparticles. This review summarises the state of the art in terms of understanding the bio-nano interface and provides direction for potential future research and recommendations for future priorities and strategies to support the safe implementation of nanotechnologies. The central premise is that nanomaterials must be studied as biological entities under the appropriate exposure conditions and that this should be implemented in study design and reporting for nanosafety assessment. The implications of the bio-nano interface for nanomaterials fate and behaviour are described in light of four interlinked perspectives: the Coating concept; the Translocation concept; the Signalling concept, and the Kinetics concept. A key conclusion is that nanoparticles cannot be viewed as non-interacting species, but rather must be thought of, and studied as, biological entities, where their interaction with the environment is mediated by the proteins and other biomolecules that adsorb to them, and the key parameter to characterise then becomes the nature, composition and evolution of the bionano interface.

show abstract

“…Although several studies have investigated the adsorption of surfactant components on different NMs such as metal or metal-oxide nanoparticles (NPs) [4][5][6][7], polystyrene NPs [8] and carbon nanotubes (CNTs) [9][10][11], it is difficult to draw general conclusions on the subject as different surfactant models have been used in each study. Some have used semisynthetic or natural surfactant preparations that do not contain SP-A and SP-D, focusing mainly on the interaction with the lipidic components [5,4,10].…”

Section: Introductionmentioning

confidence: 99%

Adsorption of surfactant protein D from human respiratory secretions by carbon nanotubes and polystyrene nanoparticles depends on nanomaterial surface modification and size

Marchetti

Shaffer

Zambianchi

et al. 2015

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

The alveolar respiratory unit constitutes one of the main targets of inhaled nanoparticles; the effect of engineered nanomaterials (NMs) on human health is largely unknown. Surfactant protein D (SP-D) is synthesized by alveolar type II epithelial cells and released into respiratory secretions; its main function is in immune defence, notably against inhaled microbes. SP-D also plays an important role in modulating an appropriate inflammatory response in the lung, and reduced SP-D is associated with a number of inflammatory lung diseases. Adsorption of SP-D to inhaled NMs may facilitate their removal via macrophage phagocytosis. This study addresses the hypothesis that the chemistry, size and surface modification of engineered NMs will impact on their interaction with, and adsorption of, SP-D. To this purpose, we have examined the interactions between SP-D in human lung lavage and two NMs, carbon nanotubes and polystyrene nanoparticles, with different surface functionalization. We have demonstrated that particle size, functionalization and concentration affect the adsorption of SP-D from human lung lavage. Functionalization with negatively charged groups enhanced the amount of SP-D binding. While SP-D binding would be expected to enhance macrophage phagocytosis, these results suggest that the degree of binding is markedly affected by the physicochemistry of the NM and that deposition of high levels of some nanoparticles within the alveolar unit might deplete SP-D levels and affect alveolar immune defence mechanisms.

show abstract

Interaction of metal oxide nanoparticles with lung surfactant protein A

Abstract: CitationInteraction of metal oxide nanoparticles with lung surfactant protein A. 2011, 77 (3):376-83 Eur J Pharm Biopharm

Cited by 80 publications

References 59 publications

The Impact of Nanoparticle Protein Corona on Cytotoxicity, Immunotoxicity and Target Drug Delivery

The Impact of Nanoparticle Protein Corona on Cytotoxicity, Immunotoxicity and Target Drug Delivery

The bio-nano-interface in predicting nanoparticle fate and behaviour in living organisms: towards grouping and categorising nanomaterials and ensuring nanosafety by design

Adsorption of surfactant protein D from human respiratory secretions by carbon nanotubes and polystyrene nanoparticles depends on nanomaterial surface modification and size

Contact Info

Product

Resources

About