Interaction of NPY and VIP in regulation of myometrial blood flow and mechanical activity

Tenmoku, Sumio; Ottesen, Bent; O'Hare, M.M.T.; Sheikh, Søren Paludan; Bardrum, B.; Hansen, Birthe; Walker, Brian; Murphy, Richard F.; Schwartz, Thue W.

doi:10.1016/0196-9781(88)90259-8

Cited by 29 publications

(11 citation statements)

References 27 publications

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“…On the other hand, in the vascular smooth muscle these peptides are known to exert opposing effects, i.e. vasoconstrictor in the case of NPY and vasodilator in the case of VIP Morris et al 1985;Morris and Murphy 1988;Tenmoku et al 1988;Morris 1990;Fahrenkrug 1993), while ACh provides vasodilation Fallgren et al 1989). In this case, the release of both functionally divergent peptides together with ACh in the vascular projecting neurones suggests a complex interaction between these transmitters in the control of the local blood flow.…”

Section: Retrograde Tracing Combined With Immunocytochemistry For Vipmentioning

confidence: 89%

“…Data is accumulating in support of the view that VIP and NPY are mainly expressed in acetylcholine (ACh)-containing neurones of the pelvic plexus Traurig and Papka 1990;Papka and Traurig 1993), and it is well established that both peptides counteract the excitatory action of ACh (through prejunctional mechanisms) to reduce the cholinergic-induced myometrial contraction in the rat (Stjernquist et al 1983;Owman 1987, 1990;Traurig and Papka 1993). Moreover, previous studies have shown that VIP also effects direct relaxation of the myometrium, mediated through a postjunctional mechanism Owman 1984, 1987;Tenmoku et al 1988). …”

Section: Retrograde Tracing Combined With Immunocytochemistry For Vipmentioning

confidence: 95%

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Coexpression of neuropeptide Y and vasoactive intestinal polypeptide in pelvic plexus neurones innervating the uterus and cervix in the rat

Houdeau

Boyer

Rousseau

et al. 1997

Cell and Tissue Research

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The present study investigates the distribution and coexpression of neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) in neurones of the accessory ganglion (AG), hypogastric plexus (HP) and paracervical ganglion (PCG), which compose the pelvic plexus in the female rat. Nerve cell bodies immunoreactive for NPY and VIP represent 84% and 46% of the neurone population in the PCG, respectively, while immunoreactivity for each peptide is observed in about 90% of the AG and HP neurones. Adjacent sections immunostained for NPY and VIP, as well as the use of immunocytochemistry combined with in situ hybridization show that 92% of the VIP-containing neurones in the pelvic plexus also contain NPY. In addition, a retrograde tracing study performed in combination with immunocytochemistry demonstrates that pelvic plexus neurones project preferentially to the lower part of the uterus and to the cervix, and that about 95% of these projecting neurones contain VIP. Taken together, our findings indicate that in the female rat, neurones of the pelvic plexus projecting to the lower genital tract mainly coexpress VIP and NPY, and supply nerve fibres to the vascular and nonvascular smooth muscle in the uterocervical region. Since NPY and VIP exert distinct effects according to the target tissue, our results suggest that neurones coexpressing these peptides play important roles in the local regulation of the vascular bed and motor activity of the lower genital tract.

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Section: Retrograde Tracing Combined With Immunocytochemistry For Vipmentioning

confidence: 89%

Section: Retrograde Tracing Combined With Immunocytochemistry For Vipmentioning

confidence: 95%

Coexpression of neuropeptide Y and vasoactive intestinal polypeptide in pelvic plexus neurones innervating the uterus and cervix in the rat

Houdeau

Boyer

Rousseau

et al. 1997

Cell and Tissue Research

View full text Add to dashboard Cite

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“…However, the receptor subtype underlying the central actions of NPY remains to be elucidated. Peripherally, NPY has been shown to modulate uterine blood flow ( Tenmoku et al ., 1988 ) and immunohistochemical studies have also shown that NPY is found in abundance in the human vagina ( Jorgensen et al ., 1989 ; Hoyle et al ., 1996 ). However, in this study, NPY failed to contract vaginal strips.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological profiling of neuropeptides on rabbit vaginal wall and vaginal artery smooth muscle in vitro

Aughton

Hamilton-Smith

Gupta

et al. 2008

British J Pharmacology

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Background and purpose: Hypothalamic neuropeptides centrally modulate sexual arousal. However, the role of neuropeptides in peripheral arousal has been ignored. Vascular and non-vascular smooth muscle relaxation in the vagina is important for female sexual arousal. To date, in vitro studies have focused on vaginal strips with no studies on vaginal arteries. The aim of this study was to compare the effects of sexual hypothalamic neuropeptides on rabbit vaginal wall strips and arteries. Experimental approach: Tissue bath and wire myography techniques were used to measure isometric tension from strips and arteries, respectively. Key results: Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) relaxed both preparations, effects that were only antagonized by the VIP/PACAP antagonist VIP6-28 (10 nM) and the PAC 1 antagonist PACAP 6-38 (1 mM). The melanocortin agonist a-melanocortin-stimulating hormone (1 mM), but not bremelanotide (1 mM), also relaxed both preparations.

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“…2. The second particularity is that two of the subtypes of the pelvic sympathetic nerves-the s.c. neuropeptide-Y autonomous (NPY) nerves and the vasoactive intestinal polypeptide (VIP) nerves-show a particular localisation for the cervix, the rectovaginal ligament and the upper vagina-where we have mostly found the infiltrating endometriosis [14][15][16]. This is of importance because these autonomic nerves, especially the NPY nerves, are one of the most powerful angiogenic factors in the body and are involved in the neoangiogenesis of the pelvic organ: they are able to cause vascular smooth muscle cell proliferation and the stimulation of endothelial cell adhesion to matrix, migration, proliferation, capillary tube formation on matrigel and aortic sprouting [17].…”

Section: Discussionmentioning

confidence: 99%

The “neurologic hypothesis”: a new concept in the pathogenesis of the endometriosis?

2005

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Interaction of NPY and VIP in regulation of myometrial blood flow and mechanical activity

Cited by 29 publications

References 27 publications

Coexpression of neuropeptide Y and vasoactive intestinal polypeptide in pelvic plexus neurones innervating the uterus and cervix in the rat

Coexpression of neuropeptide Y and vasoactive intestinal polypeptide in pelvic plexus neurones innervating the uterus and cervix in the rat

Pharmacological profiling of neuropeptides on rabbit vaginal wall and vaginal artery smooth muscle in vitro

The “neurologic hypothesis”: a new concept in the pathogenesis of the endometriosis?

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