Interactions between Caveolin-1 (rs3807992) polymorphism and major dietary patterns on cardio-metabolic risk factors among obese and overweight women

Abstract

Background Caveolin-1 (CAV-1) is a cholesterol-dependent essential component located in caveolae. Several studies have been CAV-1 related to cardio-metabolic parameters in animal models, however, there are few studies in humans. Importantly, there is no study has investigated the interaction between CAV-1 rs3807992 gene and dietary patterns (DPs) on cardio-metabolic risk factors. Methods The current cross-sectional study was conducted on 404 overweight and obese women. Dietary intake was obtained from FFQ with 147 items. The CAV-1 genotype was measured by the PCR-RFLP method. The anthropometric measurements, serum lipid profile, and inflammatory markers were measured by standard protocols. Results There was a significant interaction between CAV-1 rs3807992 and healthy DP on high-density cholesterol (HDL) (P-interaction = 0.03), TC/HDL (P-interaction = 0.03) and high sensitivity C-reactive protein (hs-CRP) (P-interaction = 0.04); in A-allele carriers, higher following a healthy DP was related to a higher level of HDL and lower TC/HDL and hs-CRP. As well as, the significant interactions were observed between CAV-1 rs3807992 and unhealthy DP in relation to triglyceride (TG) (P-interaction = 0.001), aspartate aminotransferase (AST) (P-interaction = 0.01) and monocyte chemoattractant protein-1(MCP-1) (P-interaction = 0.01); A-allele carriers were more following the unhealthy DP had lower levels of TG, AST and MCP-1. Conclusions Our study revealed a significant gene-diet interaction between rs3807992 SNPs and DPs in relation to cardio-metabolic risk factors; A-allele carriers might be more sensitive to dietary composition compared to GG homozygotes. Following a healthy DP in A-allele-carriers may be improved their genetic association with cardio-metabolic risk factors.

Interactions between Caveolin-1 polymorphism and Plant-based dietary index on metabolic and inflammatory markers among women with obesity

“…Beside, the lower liver enzyme in A-allele carriers following an hPDI in the present study can be dependent on the caffeine intake during the hPDI. In this term, we previously found a decreased AST in A-allele carriers who consumed more caffeine in a healthy dietary pattern 45 .Interestingly, a candidate gene for the favorable impact of caffeine consumption is located near the CAV-1 gene 75 , Therefor, we suggested a possible interaction between caffeine and CAV-1, which we hope will be confirmed in future study.…”

“…Serum insulin level was also measured by radioimmune assay. More detailed about biochemical measuring are reported in our previous study 45 .…”

Caveolin-1 genetic polymorphism interacts with PUFA to modulate metabolic syndrome risk

“…It was observed that a genetic variant of CAV-1 (rs3807992) was associated with increased MetS risk, which is consistent with previous studies that revealed a significant association between the minor allele in CAV-1 variations and the odds of metabolic diseases (10,11,15,17) . Previous studies by our research team have shown association between CAV-1 rs3807992 and metabolic disease (21,22) . Also, compared with other candidate gene studies, no studies had evaluated SNP rs3807992 and MetS risk.…”

Interactions between caveolin 1 polymorphism and the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND) diet on metabolic dyslipidemia in overweight and obese adult women: a cross-sectional study

“…Another study examined the main role of the CAV1 gene in developing the cardiovascular disease with an effect on lipid factors and reported significant associations [ 14 ]. In this regard, we recently explored information about the interaction between CAV1 and dietary intake in overweight and obese women [ 15 , 16 ].…”