Interactions between Marek's Disease Herpesvirus and Avian Leucosis Virus in Tissue Culture

Frankel, Jack W.; Groupé, Vincent

doi:10.1038/newbio234125a0

Cited by 22 publications

(12 citation statements)

References 8 publications

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“…The enhanced virulence could not be attributed to antigenic differences (agar gel precipitin or neutralization) of the herpes viruses in MDHV and MDHV-A preparations. It should be emphasized that these observations, as well as previous reports of viral interaction by our laboratory [14][15][16][17]22], do not imply that MDHV required the presence of oncornavirus(es) in order to produce disease. However, the nature of the disease may be drastically affected by the presence of both the herpesvirus and an oncornavirus.…”

Section: Discussionmentioning

confidence: 64%

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Contrasting Characteristics of Marek’s Disease Herpesvirus Isolated from Chickens with and without Avian Leukosis Virus Infection

Campbell¹,

Küfe²,

Peters³

et al. 1978

Intervirology

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Marek’s disease herpesvirus (MDHV) isolated from chickens free of naturally occurring avian leukosis virus (ALV) infection produced characteristic foci in both chicken embryo fibroblast (CEF) and chicken kidney cell (CKC) cultures. MDHV-A, which was extracted from the feather follicle epithelium of chickens naturally infected with ALV, did not induce cy tologic changes in CEF cultures, but did cause focus formation in CKC cultures. ALV was detected in MDHV-A, but not in MDHV preparations. MDHV-A (reconstructed in vivo) and MDHV were further distinguished from one another by inoculation of ALV-free LSI-SPF chickens. MDHV-A elicited a high incidence of early mortality which was not accompanied by the gross tumor spectrum characteristic of Marek’s disease, although extensive histologic lesions were present. The differences between MDHV and MDHV-A were not as striking in another line of ALV-free chickens (SPAFAS). By contrast, among conventional chickens with naturally occurring ALV infection, neither MDHV-A nor MDHV caused appreciable early mortality although both were highly oncogenic (gross tumor development). These observations demonstrate that the presence of an oncornavirus (ALV), detected by radioimmune but not complement fixation assays, can influence the in vitro and in vivo characteristics of an oncogenic herpesvirus (MDHV). The observations recorded here resolve some of the inconsistencies reported in the literature. Thus, the apparent failure by some to find interactions between MDHV and oncornaviruses can be ascribed to the comparatively limited sensitivity of the complement fixation assay used to detect oncornaviruses (ALV). We have shown that the presence of oncornavirus detectable by radioimmune assay, but not by complement fixation, can influence the in vitro and in vivo responses of an oncogenic herpesvirus (MDHV). Our observations relating to viral interaction do not imply that MDHV required the presence of ALV to produce disease.

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Section: Discussionmentioning

confidence: 64%

“…Chicken kidney cell (CKC) [12] and chicken embryo fibroblast (CEF) [22] cultures were maintained with Eagle's MEM containing 0.5% heat-inactivated fetal calf serum in an atmosphere of 5% CO» in air. CKC cultures were obtained from strictly quarantined SPAFAS chickens 10 days of age.…”

Section: Mdhvmentioning

confidence: 99%

Contrasting Characteristics of Marek’s Disease Herpesvirus Isolated from Chickens with and without Avian Leukosis Virus Infection

Campbell¹,

Küfe²,

Peters³

et al. 1978

Intervirology

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“…These data suggested, among other possibilities, that genome rescue by cocultivation may simply be due to the presence of HVS-infected lymphocytes in the tissues exam ined. Possible type-C viral interactions have been reported in herpesvirusassociated malignancies of chickens and man [7,15,24], One preliminary report [2] described RNase-sensitive DNA polymerase activity in an HVS lymphoma-derived epitheloid cell line. To examine the possible associa tion of type-C virus with HVS disease, tissues from an animal with lym phoma (At 981-H) were examined for viral-like RNA-dependent DNA polymerase activity, inter-species antigenic reactivity (SSV-1 and GAV-1 gs-1) and RNA which was hybridizable with DNA complementary to the SSV-1 genome (cDNA).…”

Section: Discussionmentioning

confidence: 99%

“…In vitro, avian leu cosis virus (RAV-2)-infected chicken embryo fibroblast cultures have been reported to show an increase in type-C viral antigens with a con comitant reduction in Marek's disease herpesvirus (MDHV) titer as com pared to the appropriate control cultures [7]. In vivo evidence for an MDHV-avian leucosis virus interaction has also been reported [24], Sim ilarly, tumors obtained from Burkitt's lymphoma patients have been shown to contain a high molecular weight RNA with an RNA-dependent DNA polymerase, and the DNA synthesized by this particle hybridized with Rauscher leukemia virus RNA [15].…”

Section: Introductionmentioning

confidence: 99%

Virological Investigations of Herpesvirus saimiri-lnSected Owl Monkeys

Neubauer¹,

Wallen²,

Rabin³

et al. 1974

J Med Primatol

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Examination of owl monkeys with Herpesvirus saimiri (HVS) infections failed to reveal site of active viral replication. Virus was readily rescued by cocultivation from many tissues; however, infectious virus or viral antigens were not detected in these same tissues. Type-C RNA viruses were not detected using RNA-dependent DNA polymerase or group-specific radioimmunoassay techniques. Nucleic acid base analogs failed to induce type-C viruses. These data lend further support to the notion that HVS is the etiological agent of HVS-induced lymphoma in owl monkeys.

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“…In general, this effect has been found to be restrictive. Restriction of repli cation and/or CPE has been reported for Marek's disease virus in cells infected with an avian leukosis virus [3] and for herpes simplex virus types 1 and 2 in cells transformed by earlier and reached higher levels in transformed avian, murine and feline RNA tumor viruses [4-b]. Restriction of herpesvirus replication has been demonstrated also in SV40- [7,8] and adenovirus-transformed cells [9].…”

mentioning

confidence: 99%

Enhanced Replication of Herpes Simplex Virus Type 1 in BHK-21 Cells Transformed by Hamster Sarcoma Virus

1980

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Untransformed and hamster sarcoma virus-transformed BHK-21 cells were compared for their ability to support productive infection with herpes simplex virus type 1. In both types of cells, infection with herpes simplex virus resulted in a lytic, productive cycle. However, inhibition of host cell RNA and DNA synthesis, transcription and replication of viral DNA, and production of infectious virus began earlier and reached higher levels in transformed cells.

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Interactions between Marek's Disease Herpesvirus and Avian Leucosis Virus in Tissue Culture

Cited by 22 publications

References 8 publications

Contrasting Characteristics of Marek’s Disease Herpesvirus Isolated from Chickens with and without Avian Leukosis Virus Infection

Contrasting Characteristics of Marek’s Disease Herpesvirus Isolated from Chickens with and without Avian Leukosis Virus Infection

Virological Investigations of Herpesvirus saimiri-lnSected Owl Monkeys

Enhanced Replication of Herpes Simplex Virus Type 1 in BHK-21 Cells Transformed by Hamster Sarcoma Virus

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Interactions between Marek's Disease Herpesvirus and Avian Leucosis Virus in Tissue Culture

Cited by 22 publications

References 8 publications

Contrasting Characteristics of Marek&rsquo;s Disease Herpesvirus Isolated from Chickens with and without Avian Leukosis Virus Infection

Contrasting Characteristics of Marek&rsquo;s Disease Herpesvirus Isolated from Chickens with and without Avian Leukosis Virus Infection

Virological Investigations of Herpesvirus saimiri-lnSected Owl Monkeys

Enhanced Replication of Herpes Simplex Virus Type 1 in BHK-21 Cells Transformed by Hamster Sarcoma Virus

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Product

Resources

About

Contrasting Characteristics of Marek’s Disease Herpesvirus Isolated from Chickens with and without Avian Leukosis Virus Infection

Contrasting Characteristics of Marek’s Disease Herpesvirus Isolated from Chickens with and without Avian Leukosis Virus Infection