Interactions between the combined genotypes of 5-HTTLPR and BDNF Val66Met polymorphisms and parenting on adolescent depressive symptoms: A three-year longitudinal study

Wang, Meiping; Xiangjuan, Tian; Zhang, Wenxin

doi:10.1016/j.jad.2020.01.064

Cited by 10 publications

(11 citation statements)

References 64 publications

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“…In this condition: a) as result of developmental resilience, Instagram users carrying the C allele were shown to be less susceptible than T/T homozygotes to the supportive maternal care during childhood, b) while T/T homozygotes took more advantage from a protective and comfortable maternal relationship, exhibiting higher asymmetry between the number of followers and followings than less sensitive ones [33]. Overall, T allele predisposes individuals to be more vulnerable or plastic according to the functional or dysfunctional attachment with the mother [34,35,36]. Otherwise, C allele determines a social development unconcerned about the advantages promoted by an appropriate maternal caring [37,18].…”

Section: Discussionmentioning

confidence: 99%

The interaction between serotonin transporter allelic variation and maternal care modulates sociability on Instagram

Bonassi¹,

Cataldo²,

Gabrieli³

et al. 2020

Preprint

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Human social interactions ensure recognition and approval from others, both in offline and online environments. This study applies a model from behavioural genetics on Instagram sociability to explore the impact of individual development on the behaviour on social networks. We hypothesize that sociable attitudes on Instagram resulted from an interaction between serotonin transporter gene alleles and the individual's social relationship with caregivers. We assess environmental and genetic components of 57 Instagram users. The self-report questionnaire Parental Bonding Instrument is adopted to determine the quality of parental bonding. The number of posts, followed users ("followings"), and followers are collected from Instagram as measures of online social activity. Additionally, the ratio between the number of followers and followings ("Social Desirability Index") was calculated to estimate the asymmetry of each user's social network. Finally, buccal mucosa cell samples were acquired, and the polymorphism rs25531 (T/T homozygotes vs C-carriers) within the serotonin transporter gene was examined. In the preliminary analysis, we identified a gender effect on the number of followings. In the main analysis, an effect of paternal care was also detected on the same variable. In line with our predictions, we specifically found a gene-environment interaction on the standardized Instagram "Social Desirability Index": users with the genotype more sensitive to environmental influences (T/T homozygotes) showed a higher Instagram "Social Desirability Index" than non-sensitive ones (C-carriers) when they experienced positive maternal care. This result may contribute to the understanding of online social behaviour from a gene*environment perspective.

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Section: Discussionmentioning

confidence: 99%

The interaction between serotonin transporter allelic variation and maternal care modulates sociability on Instagram

Bonassi¹,

Cataldo²,

Gabrieli³

et al. 2020

Preprint

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“…The L allele increased the risk of the disorder in combination with at least one T allele. In adolescents, the simultaneous presence of several combinations of 5-HTTLPR and BDNF (SS+CT; L allele+CC and SS+CC) but not (L allele+TT, SS+TT and L allele+CT) led to fewer depressive symptoms in case of higher levels of positive parenting (Wang et al 2020). The importance of the evaluation of gene-gene interactions in relation to ADs was also supported by other researchers (Kostic et al 2016).…”

Section: Discussionmentioning

confidence: 71%

“…Although some data indicated an interaction between BDNF and serotonin signalling in mood control (Martinowich and Lu 2008), only several studies were aimed at the evaluation of gene-gene interaction of the described genetic variations with AD susceptibility (Grabe et al 2012;Kostic et al 2016;Nestor et al 2019;Wang et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of 5-HTTLPR (insertion/deletion) and BDNF (rs6265) genetic variations in the Slovakian individuals suffering from affective disorders

Bednarova

Čižmáriková²,

Habalová³

et al. 2021

gpb

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The pathophysiology of affective disorders (AD), including depressive disorders (DD) and anxiety disorders (ANXD), is still unclear. To understand risk factors of the disorders, we evaluated genetic variations of the serotonin reuptake transporter (5-HTTLPR, ins/del) and the brain-derived neurotrophic factor (BDNF, rs6265) in Slovak patients suffering from AD. After genotyping we observed a significantly increased frequency of LS and LL genotypes (5-HTTLPR) in individuals diagnosed with AD compared to controls (OR = 1.99, 95% CI = 1.21-3.27, p = 0.006). There was also a significant relationship between TT (BDNF) genotype and the risk of AD in males (OR = 5.93, 95% CI = 1.42-27.07, p = 0.011). In gene-gene analysis, the LL or LS (5-HTTLPR) and CT or TT (BDNF) genotype combinations had a risk-enhancing effect on AD susceptibility (mainly ANXD in males), while SS (5-HTTLPR) and TT (BDNF) combination had a protective effect on AD risk (mainly ANXD). However, larger prospective studies are needed to confirm our findings.

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“…The genotype distribution for 5-HTTLPR ( n = 10, LL; n = 237, SL; n = 624, SS) was consistent with Hardy–Weinberg equilibrium ( p = 0.06). Owing to the frequency of the LL genotype is very low in our sample ( n = 10), and such a small sample was insufficient for analysis, in line with previous studies with Asian population 28 , 29 , the LL and SL genotypes were collapsed into an L allele group and coded as 1, SS genotype was coded as 0, to maximize the power of the analyses. There was no gender difference in genotype frequencies (χ 2 = 4.67, d = 2, p = 0.10).…”

Section: Resultsmentioning

confidence: 99%

Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms

Lin

Cao

et al. 2021

Sci Rep

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Many efforts have been devoted to investigating the effect of the interaction between the serotonin transporter gene (5-HTTLPR) and environment (G × E) on depression, but they yield mixed results. The inconsistency has suggested that G × E effects may be more complex than originally conceptualized, and further study is warranted. This study explored the association among 5-HTTLPR, peer victimization and depressive symptoms and the underlying mediating role of inhibitory control in this association. A total of 871 Chinese Han adolescents (Mage = 15.32 years, 50.3% girls) participated and provided saliva samples from which the 5-HTTLPR was genotyped. This study found that 5-HTTLPR interacted with peer victimization in predicting depressive symptoms. Adolescents carrying L allele reported more depressive symptoms than SS carriers when exposed to higher level of peer victimization. Furthermore, adolescents’ inhibitory control deficits mediated the association between 5-HTTLPR × peer victimization and depressive symptoms. These findings suggested that one pathway in which G × E may confer vulnerability to depressive symptoms is through disruptions to adolescents’ inhibitory control system.

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Interactions between the combined genotypes of 5-HTTLPR and BDNF Val66Met polymorphisms and parenting on adolescent depressive symptoms: A three-year longitudinal study

Cited by 10 publications

References 64 publications

The interaction between serotonin transporter allelic variation and maternal care modulates sociability on Instagram

The interaction between serotonin transporter allelic variation and maternal care modulates sociability on Instagram

Evaluation of 5-HTTLPR (insertion/deletion) and BDNF (rs6265) genetic variations in the Slovakian individuals suffering from affective disorders

Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms

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