Interactions between toluene and alcohol

Pryor, Gordon T.; Howd, Robert A.; Uyeno, Edward T.; Thurber, Andrea B.

doi:10.1016/0091-3057(85)90013-9

Cited by 21 publications

(15 citation statements)

References 22 publications

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“…In the present study, the exposure to toluene alone induced the expected loss of auditory sensitivity (Pryor et al 1985;Johnson et al 1988) with the largest loss at the midfrequency (12.5 kHz). The sensitivity was not affected by the exposure to ethanol alone, as was also seen by Pryor et al (1985).…”

Section: Discussionsupporting

confidence: 44%

Function of the Auditory System, the Visual System, and Peripheral Nerve and Long‐Term Combined Exposure to Toluene and Ethanol in Rats

Nylén

Hagman

Johnson

1995

Pharmacology & Toxicology

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Male pigmented rats (n = 36) were exposed to toluene and/or ethanol (1000 p.p.m. toluene in the inhaled air 21 hr/day, and 5.7-8.0% ethanol in the drinking water continuously) during 8 weeks. Electrophysiological recordings were made 1 week after the exposure. Auditory sensitivity (auditory brainstem response) was reduced only after exposures including toluene. At 20 kHz, ethanol antagonized toluene-induced loss of auditory sensitivity (P < 0.05). Flash evoked potentials were not affected in any group. In peripheral nerve, exposures containing ethanol were followed by increased amplitudes of nerve and muscle action potentials. Exposures including toluene were followed by an increase in liquid consumption.

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Section: Discussionsupporting

confidence: 44%

Function of the Auditory System, the Visual System, and Peripheral Nerve and Long‐Term Combined Exposure to Toluene and Ethanol in Rats

Nylén

Hagman

Johnson

1995

Pharmacology & Toxicology

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“…The results of the present experiments show that toluene exposure of rats forced to drink ethanol induces a decrease in preference to ethanol in certain conditions. This is in contrast to the results of Geller et al (1983) andPryor et al (1985). Our results, therefore, do not support their conclusion that rats exposed to toluene and forced to drink ethanol develops a preference for ethanol.…”

Section: Discussioncontrasting

confidence: 99%

“…daily for five days to very high concentrations of toluene increased their preference for ethanol. Pryor et al (1985) showed that rats exposed to both toluene and ethanol subsequently developed a marked preference for a 6% ethanol solution in a two-bottle choice test. Rats exposed to toluene without access to ethanol during the exposure, in contrary, showed an aversion to the ethanol solution.…”

mentioning

confidence: 99%

Effect of Toluene on Ethanol Preference in Rats

Ladefoged¹,

Kjær²,

Larsen³

1990

Pharmacology & Toxicology

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The effect of toluene on the preference of ethanol was studied in rats. Toluene was administered orally by stomac tube in doses of 200, 400 or 800 mg/kg daily for 5 weeks or by inhalation at a concentration of 2000 p.p.m. 6 or 8 hr daily for 5 or 6 days per week for 2 weeks in rats of different age. During toluene inhalation exposure the rats had access to either tap water or ethanol-containing water (6 or 10%). After the exposure and during oral administration the rats had access to both ethanol-free and ethanol-containing water. Toluene inhibited the body weight gain in the highest oral dose group and in rats exposed to toluene and forced to drink ethanol in the inhalation experiments. In these experiments, the intake of fluid was reduced in the exposure period in rats forced to drink ethanol-containing water and further reduced in rats exposed to both ethanol and toluene. Exposure to toluene alone increased the fluid consumption. The preference of ethanol defined as consumed ethanol-containing water in per cent of the total water intake was not influenced by oral administration of toluene. It was, however, reduced by toluene given by inhalation to rats forced to drink ethanol-containing water during the exposure period. Toluene exposure alone or forced ethanol intake alone caused in these experiments a short-lasting reduction of the ethanol preference. It is concluded that toluene decreases the preference of ethanol in rats forced to drink ethanol during exposure to toluene.

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“…Toluene ototoxicity has been discus sed previously. Evidence indicating that toluene exposure affects hearing comes mainly from studies conducted with toluene abusers (21)(22)(23)(24) and animal s (8,(27)(28)(29)(30)(31). In rats toluene interacted synergistically with noise.…”

Section: Discussionmentioning

confidence: 99%