Interactions of 2,2,2-trifluoroethanol with aqueous micelles of Triton X-100

García-Blanco, Francisco; Elorza, M.; Arias, Concepción; Elorza, B.; Gómez-Escalonilla, Ismael; Civera, Concepción; Galera-Gómez, P.A.

doi:10.1016/j.jcis.2008.10.040

Cited by 18 publications

(17 citation statements)

References 52 publications

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“…Moreover, it may be the case that the equilibrium concentration for the curved surface of a drop is not the same as for that of a flat surface. To address this, data obtained using the pendant drop data due to García‐Blanco et al34 were used to correct the values of surface tension obtained here. Wilhelmy plate measurements were obtained on the reservoir for four different Triton X‐100 concentrations: 0.01, 0.1, 1, and 10 mg/L.…”

Section: Experimental Methodsmentioning

confidence: 99%

Ruthenium‐Catalyzed Isoquinolone Synthesis through CH Activation Using an Oxidizing Directing Group

Feng

et al. 2011

Chemistry A European J

299

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Mesler entrainment is the formation of large numbers of small bubbles which occurs when a drop strikes a liquid reservoir at a relatively low velocity. Existing studies of Mesler entrainment have focused almost exclusively on water as the working fluid in a nominally clean state, where even very small levels of contamination can cause significant changes in surface tension that affect the repeatability of the results. Herein water combined with the soluble surfactant Triton X‐100 is used as the working fluid in an attempt to stabilize the state of the water surface. Despite this approach, nominally identical drops did not always result in the same bubble formation event. Accordingly, Mesler entrainment was quantified by its frequency of occurrence for drops having the same nominal diameter and impact velocity. This frequency of occurrence was found to be well correlated to both the Weber number and the shape of the drop on impact. © 2011 American Institute of Chemical Engineers AIChE J, 2012

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Section: Experimental Methodsmentioning

confidence: 99%

Ruthenium‐Catalyzed Isoquinolone Synthesis through CH Activation Using an Oxidizing Directing Group

Feng

et al. 2011

Chemistry A European J

299

View full text Add to dashboard Cite

show abstract

“…33 Moreover, it may be the case that the equilibrium concentration for the curved surface of a drop is not the same as for that of a flat surface. To address this, data obtained using the pendant drop data due to García-Blanco et al 34 were used to correct the values of surface tension obtained here. Wilhelmy plate measurements were obtained on the reservoir for four different Triton X-100 concentrations: 0.01, 0.1, 1, and 10 mg/L.…”

Section: Experimental Methodsmentioning

confidence: 99%

“…Wilhelmy plate measurements were obtained on the reservoir for four different Triton X-100 concentrations: 0.01, 0.1, 1, and 10 mg/L. The difference between the values of r obtained at each of these concentrations, and those obtained by García-Blanco et al 34 were computed. On the average, the pendant drop measurements were larger than those obtained here by 13…”

Section: Experimental Methodsmentioning

confidence: 99%

An experimental study of Mesler entrainment on a surfactant‐covered interface: The effect of drop shape and Weber number

2011

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Mesler entrainment is the formation of large numbers of small bubbles which occurs when a drop strikes a liquid reservoir at a relatively low velocity. Existing studies of Mesler entrainment have focused almost exclusively on water as the working fluid in a nominally clean state, where even very small levels of contamination can cause significant changes in surface tension that affect the repeatability of the results. Herein water combined with the soluble surfactant Triton X-100 is used as the working fluid in an attempt to stabilize the state of the water surface. Despite this approach, nominally identical drops did not always result in the same bubble formation event. Accordingly, Mesler entrainment was quantified by its frequency of occurrence for drops having the same nominal diameter and impact velocity. This frequency of occurrence was found to be well correlated to both the Weber number and the shape of the drop on impact. V

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“…[3][4][5][6][7] Previous work has demonstrated that the location of APIs on a carrier is governed by the API's hydrophobicity, with more hydrophobic drugs preferentially localized towards the core and hydrophilic drugs towards the corona. [4][5][6][7] Traditionally, a 'pocket' model has been used to describe and visualize the encapsulation of hydrophobic molecules, in which the hydrophobic APIs reside as a separate core phase surrounded by a hydrophilic shell. This model is perhaps misleading and is based more on visual simplicity than data.…”

Section: Introductionmentioning

confidence: 99%

“…Traditionally, delivery vehicles are derived from amphiphilic carriers and are described as being composed of three regions: (i) the hydrophobic core, (ii) the hydrophilic corona, and (iii) the interfacial region between the core and corona, where hydrophobic groups are hydrated (Fig. ) . Previous work has demonstrated that the location of APIs on a carrier is governed by the API's hydrophobicity, with more hydrophobic drugs preferentially localized towards the core and hydrophilic drugs towards the corona .…”

Section: Introductionmentioning

confidence: 99%

Spatial location of indomethacin associated with unimeric amphiphilic carrier macromolecules as determined by nuclear magnetic resonance spectroscopy

Orban

Moretti

Uhrich

2016

Magnetic Reson in Chemistry

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A combination of nuclear magnetic resonance (NMR) techniques including, proton NMR, relaxation analysis, two-dimensional nuclear Overhauser effect spectroscopy, and diffusion-ordered spectroscopy, has been used to demonstrate the spatial location of indomethacin within a unimolecular micelle. Understanding the location of drugs within carrier molecules using such NMR techniques can facilitate rational carrier design. In addition, this information provides insight to encapsulation efficiency of different drugs to determine the most efficient system for a particular bioactive. This study demonstrates that drugs loaded by the unimolecular amphiphile under investigation are not necessarily encapsulated but reside or localize to the periphery or interfacial region of the carrier molecule. The results have further implications as to the features of the unimolecular carrier that contribute to drug loading. In addition, evidence of drug retention associated with the unimolecular surfactant is possible in organic media, as well as in an aqueous environment. Such findings have implications for rational carrier design to correlate the carrier features to the drug of interest and indicate the strong retention capabilities of the unimolecular micelle for delivery applications. Copyright © 2016 John Wiley & Sons, Ltd.

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Interactions of 2,2,2-trifluoroethanol with aqueous micelles of Triton X-100

Cited by 18 publications

References 52 publications

Ruthenium‐Catalyzed Isoquinolone Synthesis through CH Activation Using an Oxidizing Directing Group

Ruthenium‐Catalyzed Isoquinolone Synthesis through CH Activation Using an Oxidizing Directing Group

An experimental study of Mesler entrainment on a surfactant‐covered interface: The effect of drop shape and Weber number

Spatial location of indomethacin associated with unimeric amphiphilic carrier macromolecules as determined by nuclear magnetic resonance spectroscopy

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