Interactions of Ethanol with Cyclic AMP

Structural and Functional Effects of Developmental Exposure to Ethanol on the Zebrafish Heart

“…An association between FAS morphologic defects, including pericardial swelling, and alcohol‐dependent inhibition of cholesterol modification of sonic hedgehog, a fetal morphogen that has a major role in proliferation, differentiation, and patterning has recently been shown (Li et al., 2007). The effects of developmental exposure to ethanol on the heart β‐adrenergic receptor‐coupled adenylyl cyclase system may also be significant as the receptor and the adenylyl cyclase are altered by ethanol treatment (Bode and Molinoff, 1988; Saito et al., 1987; Volicer and Gold, 1975).…”

Urinary cyclic AMP and vasopressin excretion in rat strains selected for their alcohol intake

“…Because our unpublished observations showed no higher plasma cAMP concentration in AA rats than in ANA rats, it is likely that the strain difference in cAMP excretion is of renal origin. Ethanol stimulates adenylate cyclase in many tissues (Volicer and Gold 1975). However, the slight strain difference in cAMP excretion already during water loading indicates that ethanol is not needed to cause difference in cAMP excretion.…”

Effect of ethanol and lactate on the basal and glucagonactivated cyclic amp formation in isolated hepatocytes

“…Using high concentrations of alcohol Gorman and Bitensky [ 151 found stimulation of adenyl cyclase in both whole liver homogenates and washed particle enzyme whereas Mashiter et al [ 161 only found stimulation in plasma membrane preparation but not in homogenates. In contrast to this, acute administration of ethanol to rats decreased the cyclic AMP level in liver cells [17], and inhibited the formation of cyclic AMP from ATP prelabelled with [3H] adenine [ 181.…”