Online trip planning is a popular service that has facilitated a lot of people greatly. However, little attention has been paid to personalized trip planning which is even more useful. In this paper, we define a highly expressive personalized route planning query-the Personalized and Sequenced Route (PSR) Query which considers both personalization and sequenced constraint, and propose a novel framework to deal with the query. The framework consists of three phases: guessing, crossover and refinement. The guessing phase strives to obtain one high quality route as the baseline to bound the search space into a circular region. The crossover phase heuristically improve the quality of multiple guessed routes via a modified genetic algorithm, which further narrows the radius of the search space. The refinement phase backwardly examines each candidate point and partial route to rule out impossible ones. The combination of these phases can efficiently and effectively narrow our search space via a few iterations. In the experiment part, we firstly show our evaluation results of each phase separately, proving the effectiveness of each phase. Then, we present the evaluation results of the combination of them, which offers insight into the merits of the proposed framework.