This study aims to develop an integrated textbook called "MERISKA" (an acronym of Metacognition, Critical Thinking, Islamic values, and Character in Indonesian). This integrated textbook MERISKA with content to practice metacognitive skills (include planning, monitoring, and evaluation in the learning process), critical thinking skills in the form of questions (which include interpretation, analyzing, evaluation, inference, explanation, and self-regulation), and the content of Islamic values through "comparative-confirmation" integration techniques in the form of relationships between verses of the Qur'an or Hadith with biology concepts, especially Cell and Molecular Biology, then finding an example of character (Akhlaq) from that relation. The development steps refer to the 4D model (defined as: define, design, develop, and disseminate). This approach is appropriate where each stage describes the process of compiling the MERISKA integrated textbook. The results indicate that the integrated textbook MERISKA, has the required criteria of validity, practicality, and effectiveness. The validation results show that the MERISKA textbook has an average validity value of 4.53 (very valid or high). The practicality results obtained an average score of 4.00 (by lecturers) and 4.53 (by students). Dissemination of product development is held through the Webinar (Web seminar) series "Integration of Islam and Science" and the publication of the textbook MERISKA with ISBN. The development of the integrated textbook MERISKA certainly provides benefits for students and lecturers. Students are facilitated by the MERISKA textbook as a learning resource, while lecturers are helped to improve their metacognitive skills, critical thinking, Islamic values, and character in the learning process.