The purpose of the article is to analyse the impact of COVID-19 on small and medium-sized businesses in the Russian Federation. Data from the research company “Evotor”, the unified register of small and medium-sized businesses, as well as data from the Central Bank of Russia were used as material for the study. Based on the results, it can be stated that the pandemic has affected the economy in different ways. A number of small and medium-sized businesses and their revenue decreased in 2021 compared to 2019. But at the same time, the sector of domestic tourism has grown over the period under review. The largest increase in the average revenue of hotels in 2021 compared to 2020 was observed in the Kaliningrad region, Krasnodar Krai and Moscow.