Intercalation and release of an anti-inflammatory drug into designed three-dimensionally layered double hydroxide nanostructure via calcination–reconstruction route

Mansouri, Elham; Tarhriz, Vahideh; Yousefi, Vahid; Dilmaghani, Azita

doi:10.1007/s10450-020-00217-4

Cited by 22 publications

(14 citation statements)

References 29 publications

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“…Novel nanomaterials are being developed to improve disease treatment processes via biopharmaceutical molecules as well as the surface treatment of biomaterials [ 8 – 9 ]. Among nanoparticles (NPs), silver nanoparticles (Ag-NPs) are successfully commercialized due to their well-known antiseptic properties.…”

Section: Introductionmentioning

confidence: 99%

Silver nanoparticles induce the cardiomyogenic differentiation of bone marrow derived mesenchymal stem cells via telomere length extension

Adibkia

Ehsani

Jodaei

et al. 2021

Beilstein J. Nanotechnol.

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Finding new strategies for the treatment of heart failures using stem cells has attracted a lot of attention. Meanwhile, nanotechnology-based approaches to regenerative medicine hypothesize a possible combination of stem cells and nanotechnology in the treatment of diseases. This study aims to investigate the in vitro effect of silver nanoparticles (Ag-NPs) on the cardiomyogenic differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs) through detection of cardiac markers. For this purpose, MSCs were isolated from bone marrow resident and differentiated to the cardiac cells using a dedicated medium with Ag-NPs. Also, the cardiomyogenic differentiation of BM-MSCs was confirmed using immunocytochemistry. Then, real-time PCR and western blotting assay were used for measuring absolute telomere length (TL) measurement, and gene and protein assessment of the cells, respectively. It was found that 2.5 µg/mL Ag-NPs caused elongation of the telomeres and altered VEGF, C-TnI, VWF, SMA, GATA-4, TERT, and cyclin D protein and gene expression in the cardiomyogenically differentiated BM-MSCs. Also, there was a significant increase in the protein and gene expression of Wnt3 and β-catenin as main components of pathways. We concluded that Ag-NPs could change the in vitro expression of cardiac markers of BM-MSCs via the Wnt3/β-catenin signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Silver nanoparticles induce the cardiomyogenic differentiation of bone marrow derived mesenchymal stem cells via telomere length extension

Adibkia

Ehsani

Jodaei

et al. 2021

Beilstein J. Nanotechnol.

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“…When the drug-loaded nanoparticles were placed in physiological buffers (pH 7.4), a partial negative surface charge on the nanoparticle was generated; this electrostatic repulsion triggered the sustained release of loaded drugs. According to the previous studies, the release assays were, hence, carried out in physiological buffers condition (pH 7.4) [ 10 , 18 ] at 37 °C which is similar to the normal body temperature.…”

Section: Resultsmentioning

confidence: 99%

“…The semiliquid mixture was aged at 70 °C overnight. The product was isolated using an external magnet, and the precipitate was rinsed three times with water and ethanol and then dried in an oven at 70 °C for 12 h. Finally, to load each drug, 3 g of synthesized-nanostructure was immersed in 100 ml distilled water containing 3 g of the desired drug (Ibuprofen and Diclofenac) and 1 g of potassium hydroxide with pH control at 9 at room temperature for 24 h [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

Synthesis and application of magnetic@layered double hydroxide as an anti-inflammatory drugs nanocarrier

et al. 2020

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Background Magnetic nanocomposites with a core–shell nanostructure have huge applications in different sciences especially in the release of the drugs, because of their exclusive physical and chemical properties. In this research, magnetic@layered double hydroxide multicore@shell nanostructure was synthesized by the facile experiment and is used as novel drug nanocarrier. Methods Magnetic nanospheres were synthesized by a facile one-step solvothermal route, and then, layered double hydroxide nanoflakes were prepared on the magnetic nanospheres by coprecipitation experiment. The synthesized nanostructures were characterized by FTIR, XRD, SEM, VSM, and TEM, respectively. After intercalation with Ibuprofen and Diclofenac as anti-inflammatory drugs and using exchange anion experiment, the basal spacing of synthesized layered double hydroxides was compared with brucite nanosheets from 0.48 nm to 2.62 nm and 2.22 nm, respectively. Results The results indicated that Ibuprofen and Diclofenac were successfully intercalated into the interlay space of LDHs via bridging bidentate interaction. In addition, in-vitro drug release experiments in pH 7.4, phosphate-buffered saline (PBS) showed constant release profiles with Ibuprofen and Diclofenac as model drugs with different lipophilicity, water solubility, size, and steric effect. Conclusion The Fe3O4@LDH-ibuprofen and Fe3O4@LDH-diclofenac had the advantage of the strong interaction between the carboxyl groups with higher trivalent cations by bridging bidentate, clarity, and high thermal stability. It is confirmed that Fe3O4@LDH multicore-shell nanostructure may have potential application for constant drug delivery.

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“…When the drug-loaded nanoparticles were placed in physiological buffers (pH 7.4), a partial negative surface charge on the nanoparticle was generated; this electrostatic repulsion triggered the sustained release of loaded drugs. According to the previous studies, the release assays were, hence, carried out in physiological buffers condition (pH 7.4) [10,18] at 37 ºC which is similar to the normal body temperature. Ibuprofen per unit of time.…”

Section: Uv-vis Spectrum Of Ibuprofen and Diclofenac Release Assaymentioning

confidence: 99%

“…The semiliquid mixture was aged at 70 o C overnight. The product was isolated using an external magnet, and the precipitate was rinsed three times with water and ethanol and then dried in an oven at 70° C for 12 h. Finally, to load each drug, 3 g of synthesized-nanostructure was immersed in 100 ml distilled water containing 3 g of the desired drug (Ibuprofen and Diclofenac) and 1 g of potassium hydroxide with pH control at 9 at room temperature for 24 h [18] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Application of Magnetic@layered Double Hydroxide as an Anti-Inflammatory Drugs Nanocarrier

Yousefi

Tarhriz

Eyvazi

et al. 2020

Preprint

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Background: Magnetic nanocomposites with a core-shell nanostructure have huge applications in different sciences especially in the release of the drugs, because of their exclusive physical and chemical properties. In this research, magnetic@layered double hydroxide multicore@shell nanostructure was synthesized by the facile experiment and is used as novel drug nanocarrier.Methods: Magnetic nanospheres were synthesized by a facile one-step solvothermal route, and then, layered double hydroxide nanoflakes were prepared on the magnetic nanospheres by coprecipitation experiment. The synthesized nanostructures were characterized by FTIR, XRD, SEM, VSM, and TEM, respectively. After intercalation with Ibuprofen and Diclofenac as anti-inflammatory drugs and using exchange anion experiment, the basal spacing of synthesized layered double hydroxides was compared with brucite nanosheets from 0.48 nm to 2.62 nm and 2.22 nm, respectively. Results: The results indicated that Ibuprofen and Diclofenac were successfully intercalated into the interlay space of LDHs via bridging bidentate interaction. In addition, in-vitro drug release experiments in pH 7.4, phosphate-buffered saline (abbreviated PBS) showed constant release profiles with Ibuprofen and Diclofenac as model drugs with different lipophilicity, water solubility, size, and steric effect. Conclusion: The Fe3O4@LDH-ibuprofen and Fe3O4@LDH-diclofenac had the advantage of the strong interaction between the carboxyl groups with higher trivalent cations by bridging bidentate, clarity, and high thermal stability. It is confirmed that Fe3O4@LDH multicore-shell nanostructure may have potential application for constant drug delivery.

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Intercalation and release of an anti-inflammatory drug into designed three-dimensionally layered double hydroxide nanostructure via calcination–reconstruction route

Cited by 22 publications

References 29 publications

Silver nanoparticles induce the cardiomyogenic differentiation of bone marrow derived mesenchymal stem cells via telomere length extension

Silver nanoparticles induce the cardiomyogenic differentiation of bone marrow derived mesenchymal stem cells via telomere length extension

Synthesis and application of magnetic@layered double hydroxide as an anti-inflammatory drugs nanocarrier

Synthesis and Application of Magnetic@layered Double Hydroxide as an Anti-Inflammatory Drugs Nanocarrier

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