Interference phase-contrast imaging technology without beam separation

Nishiwaki, Seiji; Narumi, K.; Korenaga, Tsuguhiro

doi:10.1038/s41598-018-38359-9

Cited by 3 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Developed by Georges Nomarski in the early 1950s [ 28 ], DIC utilizes polarized light that is passed through a prism, through the specimen, and then through another prism and depolarized to produce interference that results in one side of the structure that the light has passed through appearing bright and the other side appearing dark. Overall, imaging cells using this technique produces a shadowing effect that gives cells a 3D-relief-like appearance [ 29 ].…”

Section: Embryo Evaluation/analysis—tools Of the Tradementioning

confidence: 99%

Pre-Implantation Bovine Embryo Evaluation—From Optics to Omics and Beyond

Rabel

Marchioretto

Bangert

et al. 2023

Animals

View full text Add to dashboard Cite

Approximately 80% of the ~1.5 million bovine embryos transferred in 2021 were in vitro produced. However, only ~27% of the transferred IVP embryos will result in live births. The ~73% pregnancy failures are partly due to transferring poor-quality embryos, a result of erroneous stereomicroscopy-based morphological evaluation, the current method of choice for pre-transfer embryo evaluation. Numerous microscopic (e.g., differential interference contrast, electron, fluorescent, time-lapse, and artificial-intelligence-based microscopy) and non-microscopic (e.g., genomics, transcriptomics, epigenomics, proteomics, metabolomics, and nuclear magnetic resonance) methodologies have been tested to find an embryo evaluation technique that is superior to morphologic evaluation. Many of these research tools can accurately determine embryo quality/viability; however, most are invasive, expensive, laborious, technically sophisticated, and/or time-consuming, making them futile in the context of in-field embryo evaluation. However accurate they may be, using complex methods, such as RNA sequencing, SNP chips, mass spectrometry, and multiphoton microscopy, at thousands of embryo production/collection facilities is impractical. Therefore, future research is warranted to innovate field-friendly, simple benchtop tests using findings already available, particularly from omics-based research methodologies. Time-lapse monitoring and artificial-intelligence-based automated image analysis also have the potential for accurate embryo evaluation; however, further research is warranted to innovate economically feasible options for in-field applications.

show abstract

Section: Embryo Evaluation/analysis—tools Of the Tradementioning

confidence: 99%

Pre-Implantation Bovine Embryo Evaluation—From Optics to Omics and Beyond

Rabel

Marchioretto

Bangert

et al. 2023

Animals

View full text Add to dashboard Cite

show abstract

“…22) The stacked tantalum oxide layers with gratings work as a grating coupler with high coupling efficiency, and guided light repeatedly undergoes coupling, directional coupling, and radiation between each layer. 23) As shown in Fig. 1(c), light incident on a CGC excites guided light propagating from the center of the input-side CGC to a neighboring CGC.…”

mentioning

confidence: 99%

Efficient light-trapping sheet for the entire visible spectrum by using stacked concentric grating couplers

Nishiwaki

Morita

Takase

2021

Appl. Phys. Express

Self Cite

View full text Add to dashboard Cite

We confirmed the effectiveness of light-trapping by forming concentric grating couplers (CGCs) inside a transparent sheet. A portion of the light incident to the CGCs is input-coupled and converted to the guided mode and is radiated from neighboring CGCs at a wider angle than the incident angle or even over the critical angle for both surfaces of the sheet. We demonstrated that three stacked sheets with multi-layered CGCs can trap an average of 19%–29% of the incident light at angles of 0° to ±70° in the visible spectrum.

show abstract

Surface-Covered 1×3 Grating With Dielectric-Metal Slabs Under Second Bragg Incidence

Wang

Zhu

et al. 2020

Surf. Rev. Lett.

View full text Add to dashboard Cite

This paper designed a novel three-port reflective surface-covered grating with a connecting layer. The grating can be used as a splitter, and the polarized light can be divided into zero order, first order and second order. Through rigorous coupled-wave analysis, the efficiency of the three orders of diffraction light is close to 33% under the condition that the incident light at 1550 nm is incident at the second Bragg angle and the given duty cycle is 0.5. The efficiency and bandwidth of the surface-covered grating are improved compared with that of the surface-relief grating reported in the past. Especially for transverse magnetic polarized light, the beam splitting effect is more uniform, the efficiency ratio of the zeroth order to first order can reach 1.01, and the efficiency ratio of the first order to second order can reach 1.

show abstract

Interference phase-contrast imaging technology without beam separation

Cited by 3 publications

References 21 publications

Pre-Implantation Bovine Embryo Evaluation—From Optics to Omics and Beyond

Pre-Implantation Bovine Embryo Evaluation—From Optics to Omics and Beyond

Efficient light-trapping sheet for the entire visible spectrum by using stacked concentric grating couplers

Surface-Covered 1×3 Grating With Dielectric-Metal Slabs Under Second Bragg Incidence

Contact Info

Product

Resources

About