Explosive boiling and lift-off of a thin layer of micron-sized transparent water droplets from an absorbing Si substrate heated by a nanosecond KrF laser were studied using a contact photoacoustic technique. The compressive photoacoustic response increases steeply to an asymptotic value on the order of the water critical pressure starting at a threshold laser fluence of 0.20J∕cm2, where lift-off of the water layer also occurs. Above this threshold, several reproducible discrete multimegahertz components are revealed in Fourier spectra of the acoustic transients, corresponding to nanosecond oscillations of steam bubbles inside the water droplets on the microsecond time scale of the lift-off process. The acoustic pressure buildup, bubble dynamics, and the subsequent lift-off of the thin water layer are interpreted as relaxation stages after near-spinodal explosive boiling of the superheated interfacial water.