Interferon Immunoregulation of Antibody Response in Normal and Autoimmune Mice Is Mediated by Suppressor T Cell Subsets

Am, Attallah; Urritia-Shaw, A.; Ry, Khalit; Ad, Steĭnberg; Ahmed, Ansar

doi:10.1159/000232714

Cited by 10 publications

(2 citation statements)

References 14 publications

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“…IFN and IL2 seem to exert a major role in immunoregulation (Gillis and Watson, 1980;Johnson and Blalock, 1980;Kadish et al, 1980;Attallah et al, 1981;Ruscetti and Gallo, 1981;Nair and Schwartz, 1983). IFN and IL2 augment NK activity both in vitro and in vivo (Herberman et al, 1979;Henny et al, 1981;Perussia and Trinchieri, 1981;Nair and Schwartz, 1982).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the cellular cytotoxic activities of colostral lymphocytes and maternal peripheral blood lymphocytes

Nair

Schwartz

Slade

et al. 1985

Journal of Reproductive Immunology

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Colostral lymphocytes (CL) from mothers 2 to 4 days post-partum and autologous maternal peripheral blood lymphocytes (PBL) were investigated for (1) natural killer (NK) and antibody-dependent cellular cytotoxic (ADCC) activities, (2) target binding ability, (3) interferon (IFN)- and interleukin 2 (IL2)-induced augmentation of NK activity, (4) lectin-dependent cellular cytotoxicity (LDCC), and (5) the ability of culture-derived soluble suppressor factor(s) to inhibit the NK activity of normal allogeneic lymphocytes. CL depleted of adherent cells and Percoll-separated NK-enriched subpopulations of CL demonstrated significantly lower NK and ADCC activities compared to autologous PBL. However, the target binding ability of CL was comparable to autologous PBL. Although the residual NK activity of CL was augmented by IFN and IL2, the activity was not enhanced to the same level shown by autologous PBL. CL also demonstrated a significant enhancement of LDCC activity, although the activity was not stimulated to the levels shown by PBL. Culture supernates of CL manifested greater suppression of the NK ability of allogeneic PBL than culture supernates produced by autologous PBL. These results are consistent with a model that suggests differential partitioning of lymphocyte subpopulations between colostrum and peripheral blood.

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Section: Discussionmentioning

confidence: 99%

Comparison of the cellular cytotoxic activities of colostral lymphocytes and maternal peripheral blood lymphocytes

Nair

Schwartz

Slade

et al. 1985

Journal of Reproductive Immunology

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“…In a previous study on the NZB model of SLE, we found that mouse IFN significantly enhanced Ig pro duction at concentrations as low as 250 IFN u/culture [24]. In another study on normal human poly clonal Ig production, lymphoblastoid IFN was found to suppress normal polyclonal Ig synthesis in a doserelated manner [11], Others have noted enhancement of in vitro human Ig biosynthesis by IFN-a and these differences appear to result, at least in part, from var ied culture conditions and IFN-a preparations used [11,25,26].…”

Section: Discussionmentioning

confidence: 79%

In vitro Effect of Alpha-Interferon on Mononuclear Cells of Normal and Autoimmune Patients

Attallah¹,

Steinberg

Clark³

et al. 1987

Int Arch Allergy Immunol

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The effect of lymphoblastoid interferon (IFN-α) on cell-mediated and humoral immunity was studied in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The base-line natural killer (NK) and antibody dependent cytotoxic cell (ADCC) activity was higher than normal in individuals with RA. The NK and ADCC activities were tested after IFN-α pretreatment and the augmentation of NK and ADCC activity was less in these patients than in normals. Lymphoblastoid IFN inhibited antigen induced T-cell proliferation in SLE to a lesser extent than in normal individuals. Finally, the addition of lymphoblastoid IFN was also less effective at suppressing in vitro polyclonal antibody formation by mononuclear cells from patients with SLE than from normals, with enhancement observed in some patients at the lower IFN-α concentrations tested.

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Natural killer cell activity and spontaneous development of lymphoma. Effects of single and multiple injections of interferon into young and aged C57BL/6 mice

Bruley-Rosset

Rappaport

1983

Intl Journal of Cancer

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The capacity of interferon (IFN) given once or repeatedly to augment natural killer (NK) cell activity in the spleen was tested in young and aged C57BL/6 mice. Multiple injections of 10(4) u IFN i.p. into 3-month-old or 12-month-old mice did not augment cytotoxicity mediated by NK cell activity; rather it reduced this activity in relation to the effect obtained with a single injection. When T and B cells or macrophages were removed in vitro, no restoration of NK-cell activity, and therefore no suppressor cells, could be found in this system. In a long-term experiment, B6 mice were chronically injected with 10(4) u of IFN or mock-IFN from 5 months of age until death. No difference in the modification of NK-cell activity was observed after IFN and mock-IFN, regardless of the duration of treatment. However, the capacity of spleen cells to generate cytotoxic T cells after allogeneic stimulation in vitro or in vivo was increased in IFN-treated mice. The median survival time was improved by 7 weeks through treatment with IFN compared to mock-IFN, but was reduced by 9 weeks compared to the survival after treatment with saline. No significant difference in the incidence of spontaneous lymphoma resulted from IFN treatment, but the percentage of tumors observed in mice receiving mock-IFN (68.1%) was higher than that in mice receiving saline (44.1%). These results indicate that, while a stimulating effect resulting in a delay in mortality and in tumor development can be attributed to IFN itself, the contaminating antigenic products are plausibly responsible for the deleterious effect of the total preparation.

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Interferon Immunoregulation of Antibody Response in Normal and Autoimmune Mice Is Mediated by Suppressor T Cell Subsets

Cited by 10 publications

References 14 publications

Comparison of the cellular cytotoxic activities of colostral lymphocytes and maternal peripheral blood lymphocytes

Comparison of the cellular cytotoxic activities of colostral lymphocytes and maternal peripheral blood lymphocytes

In vitro Effect of Alpha-Interferon on Mononuclear Cells of Normal and Autoimmune Patients

Natural killer cell activity and spontaneous development of lymphoma. Effects of single and multiple injections of interferon into young and aged C57BL/6 mice

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