Interfractional Positional Variability of Fiducial Markers and Primary Tumors in Locally Advanced Non-Small-Cell Lung Cancer During Audiovisual Biofeedback Radiotherapy

Roman, N.; Shepherd, Wes; Mukhopadhyay, Nitai D.; Hugo, Geoffrey D.; Weiss, Elisabeth

doi:10.1016/j.ijrobp.2011.10.051

Cited by 63 publications

(61 citation statements)

References 20 publications

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“…The short-term safety of fiducial markers was described in Roman et al [3] for 6 of the patients included in this study and was comparable to the previous studies. The two additional patients included in the present investigation did not have any procedural complications such as pneumothorax, pneumomediastinum, bleeding or infection.…”

Section: Procedures Safetysupporting

confidence: 87%

“…See Table 1 for patient and treatment characteristics. Further details on patient characteristics and image acquisition are reported in Roman et al [3]. …”

Section: Patient Characteristicsmentioning

confidence: 99%

“…The last follow-up CT scans revealed that 15 out of 19 of fiducials remained in the same anatomical location longterm. Short-term marker during-treatment stability for 6 of the patients included in this study was described in Roman et al [3] -two markers were expectorated during radiotherapy leaving 17 fiducials in place. The two additional patients included in the present investigation retained their fiducials throughout treatment.…”

Section: Marker Retentionmentioning

confidence: 99%

“…While significant improvements in imaging technology lead to improved tumor delineation, other challenges such as respiratory and cardiac-induced motion, setup inconsistencies, and volume changes and deformation result in significant uncertainties when it comes to targeting the tumor and minimizing normal tissue toxicity [1][2][3]. Both conventional fractionation and SBRT necessitate accurate delivery of radiotherapy [4].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Long-Term Safety and Stability of Gold Coil Fiducial Markers in Non-Small-Cell Lung Cancer Image-Guided Radiotherapy

Reshko

Shepherd

Weiss

2017

IJRRT

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Section: Procedures Safetysupporting

confidence: 87%

“…See Table 1 for patient and treatment characteristics. Further details on patient characteristics and image acquisition are reported in Roman et al [3]. …”

Section: Patient Characteristicsmentioning

confidence: 99%

Section: Marker Retentionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Long-Term Safety and Stability of Gold Coil Fiducial Markers in Non-Small-Cell Lung Cancer Image-Guided Radiotherapy

Reshko

Shepherd

Weiss

2017

IJRRT

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“…A previous study has applied this approach for the assessment of Differences in displacement of the proximal and distal ends of mid-upper thoracic esophageal squamous cell carcinoma ITV margins with free breathing for external-beam partial breast irradiation in patients following breast-conserving surgery (11). Recently, bronchoscopy-assisted implantation of markers has been used for the determination of tumor-based setup during image-guided lung cancer radiotherapy with audiovisual biofeedback (12,13). Metal objects are rigid, dense and well-defined, and provide a sharp contrast against the surrounding tissues, which they may be attached to, rendering them optimal and easily identifiable markers to track tumor motion.…”

Section: Introductionmentioning

confidence: 99%

Differences in displacement of the proximal and distal ends of mid-upper thoracic esophageal squamous cell carcinoma

Qiu

Wen

et al. 2016

Molecular and Clinical Oncology

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Abstract. In the present study, clips were used as markers to evaluate displacement differences between proximal and distal ends of esophageal tumors and to test whether their internal target volume (ITV) margins should be determined separately. A total of 23 patients with mid-upper thoracic esophageal squamous-cell carcinoma, a tumor length of ≤8 cm and an esophageal lumen suitable for endoscopic ultrasonography were recruited for the present study. Clips were implanted endoscopically at the proximal and distal ends of the esophageal tumor (upper and lower clips). In a further exploratory study on 16 of the patients, a third clip was placed at the distal esophagus 2 cm above the gastro-esophageal junction (GEJ) (cardiac clip). The clips were contoured for all 10 phases of the four-dimensional computed tomography and the maximum displacements of the clip centroids among different breathing phases in left-right (LR), superior-inferior (SI) and anterior-posterior (AP) directions were marked as x, y and z, respectively. The ITV margins that covered 95% of the LR, SI and AP motion were 2.89, 5.00 and 2.36 mm, respectively. Axial displacement (y) was greater than radial displacement (x, z; P<0.05). It was also revealed that LR(x), SI(y) and AP(z) displacement of cardiac clips was greater than that of upper or lower clips (P<0.05). Differences in the axial and radial displacement of the upper and lower clips indicated that axial and radial ITV margins should be determined separately. However, further study is required on patients in whom the distal tumor end is located in proximity to the GEJ.

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Thoracic motion‐compensated cone‐beam computed tomography in under 20 seconds on a fast‐rotating linac: A simulation study

Blake

Dillon

Byrne

et al. 2023

J Applied Clin Med Phys

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Background: Rapid kV cone-beam computed tomography (CBCT) scans are achievable in under 20 s on select linear accelerator systems to generate volumetric images in three dimensions (3D). Daily pre-treatment four-dimensional CBCT (4DCBCT) is recommended in image-guided lung radiotherapy to mitigate the detrimental effects of respiratory motion on treatment quality.Purpose: To demonstrate the potential for thoracic 4DCBCT reconstruction using projection data that was simulated using a clinical rapid 3DCBCT acquisition protocol. Methods: We simulated conventional (1320 projections over 4 min) and rapid (491 projections over 16.6 s) CBCT acquisitions using 4D computed tomography (CT) volumes of 14 lung cancer patients. Conventional acquisition data were reconstructed using the 4D Feldkamp-Davis-Kress (FDK) algorithm. Rapid acquisition data were reconstructed using 3DFDK, 4DFDK, and Motion-Compensated FDK (MCFDK). Image quality was evaluated using Contrastto-Noise Ratio (CNR), Tissue Interface Width (TIW), Root-Mean-Square Error (RMSE), and Structural SIMilarity (SSIM). Results:The conventional acquisition 4DFDK reconstructions had median phase averaged CNR, TIW, RMSE, and SSIM of 2.96, 8.02 mm, 83.5, and 0.54, respectively. The rapid acquisition 3DFDK reconstructions had median CNR, TIW, RMSE, and SSIM of 2.99, 13.6 mm, 112, and 0.44 respectively. The rapid acquisition MCFDK reconstructions had median phase averaged CNR, TIW, RMSE, and SSIM of 2.98, 10.2 mm, 103, and 0.46, respectively. Rapid acquisition 4DFDK reconstruction quality was insufficient for any practical use due to sparse angular projection sampling. Conclusions: Results suggest that 4D motion-compensated reconstruction of rapid acquisition thoracic CBCT data are feasible with image quality approaching conventional acquisition CBCT data reconstructed using standard 4DFDK.

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Interfractional Positional Variability of Fiducial Markers and Primary Tumors in Locally Advanced Non-Small-Cell Lung Cancer During Audiovisual Biofeedback Radiotherapy

Cited by 63 publications

References 20 publications

Long-Term Safety and Stability of Gold Coil Fiducial Markers in Non-Small-Cell Lung Cancer Image-Guided Radiotherapy

Long-Term Safety and Stability of Gold Coil Fiducial Markers in Non-Small-Cell Lung Cancer Image-Guided Radiotherapy

Differences in displacement of the proximal and distal ends of mid-upper thoracic esophageal squamous cell carcinoma

Thoracic motion‐compensated cone‐beam computed tomography in under 20 seconds on a fast‐rotating linac: A simulation study

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