Interhemispheric resting state functional connectivity abnormalities in unipolar depression and bipolar depression

Wang, Ying; Zhong, Shuming; Jia, Yanbin; Zhou, Zhifeng; Wang, Bin; Pan, Jiyang; Huang, Li

doi:10.1111/bdi.12315

Cited by 117 publications

(58 citation statements)

References 54 publications

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“…Most of the network differences in our study between these groups comprised inter-hemispheric differences. So far, there are several studies that show decreased inter-hemispheric FC in MDD 36–40 . However, the biological background of inter-hemispheric FC abnormalities is not fully understood, although studies from split brain patients suggest that a disruption of inter-hemispheric FC affects the information processing and functioning of the brain 41, 42 .…”

Section: Discussionmentioning

confidence: 99%

Aberrant functional connectivity in depression as an index of state and trait rumination

Rosenbaum

Haipt

Fuhr

et al. 2017

Sci Rep

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Depression has been shown to be related to a variety of aberrant brain functions and structures. Particularly the investigation of alterations in functional connectivity (FC) in major depressive disorder (MDD) has been a promising endeavor, since a better understanding of pathological brain networks may foster our understanding of the disease. However, the underling mechanisms of aberrant FC in MDD are largely unclear. Using functional near-infrared spectroscopy (fNIRS) we investigated FC in the cortical parts of the default mode network (DMN) during resting-state in patients with current MDD. Additionally, we used qualitative and quantitative measures of psychological processes (e.g., state/trait rumination, mind-wandering) to investigate their contribution to differences in FC between depressed and non-depressed subjects. Our results indicate that 40% of the patients report spontaneous rumination during resting-state. Depressed subjects showed reduced FC in parts of the DMN compared to healthy controls. This finding was linked to the process of state/trait rumination. While rumination was negatively correlated with FC in the cortical parts of the DMN, mind-wandering showed positive associations.

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Section: Discussionmentioning

confidence: 99%

Aberrant functional connectivity in depression as an index of state and trait rumination

Rosenbaum

Haipt

Fuhr

et al. 2017

Sci Rep

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“…The precuneus and PCC, the major hub nodes of the DMN, are related to a wide range of cognitive functions, such as episodic memory retrieval, modulation of emotionally salient memories, self-consciousness, and visuo-spatial imagery 37 . Several R-fMRI studies also indicated involvement of the precuneus/PCC in mood disorders, including abnormal spontaneous activity 38 and functional connectivity 28, 39–42 . Previous task-fMRI studies also reported abnormal activity in the precuneus/PCC in BD and MDD patients during cognitive and emotional tasks 43–45 .…”

Section: Discussionmentioning

confidence: 99%

“…The clinical state of each patient was assessed using the 24-item Hamilton Depression Rating Scale (HAMD) and the Young Mania Rating Scale (YMRS) during the seven-day period prior to the R-fMRI scan. The inclusive criteria were a HAMD-24 total score > 21 for the MDD patients and a YMRS total score < 7 and a HAMD-24 total score > 21 for the BD patients 28 . The exclusion criteria were patients with other Axis-I psychiatric disorders (except for UD, BD, and anxiety disorders), a history of organic brain disorder, neurological disorders, mental retardation, cardiovascular diseases, alcohol or substance abuse, pregnancy, or any physical illness.…”

Section: Methodsmentioning

confidence: 99%

Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder

Wang

Jia

et al. 2017

Sci Rep

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Identifying brain differences and similarities between bipolar disorder (BD) and major depressive disorder (MDD) is necessary for increasing our understanding of the pathophysiology and for developing more effective treatments. However, the features of whole-brain intrinsic functional connectivity underlying BD and MDD have not been directly compared. We collected resting-state fMRI data from 48 BD patients, 48 MDD patients, and 51 healthy subjects. We constructed voxel-wise whole-brain functional networks and computed regional functional connectivity strength (FCS) using graph-theory and further divided the regional FCS into long-range FCS (lFCS) and short-range FCS (sFCS). Relative to the controls, both the BD and MDD patients showed decreased sFCS in the bilateral precuneus. In addition, the BD patients showed increased and the MDD patients showed decreased lFCS and sFCS in the bilateral cerebellum. The BD patients also showed increased lFCS in the right middle temporal gyrus and increased sFCS in the bilateral thalamus compared to either the MDD patients or the controls. These findings suggest that BD and MDD may have some shared as well as a greater number of specific impairments in their functional connectivity patterns, providing new evidence for the pathophysiology of BD and MDD at the large-scale whole brain connectivity level.

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“…Recently, several studies have explored the differences in FC between BD and MDD using resting-state (Ellard et al 2015; Goya-Maldonado et al 2016; Marchand et al 2013; Wang et al 2015) or task-related fMRI (Anand et al 2009; Redlich et al 2015; Satterthwaite et al 2015). We previously studies compared neuroimaging data between BD and MDD by constructing the functional network connectivity (FNC), composed of a whole brain graph with nodes defined by independent components analysis (ICA) (Jafri et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Co-altered functional networks and brain structure in unmedicated patients with bipolar and major depressive disorders

Sui

et al. 2017

Brain Struct Funct

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Bipolar disorder (BD) and major depressive disorder (MDD) share similar clinical characteristics that often obscure the diagnostic distinctions between these conditions. Both functional and structural brain abnormalities have been reported in these two disorders. However, the direct link between altered functioning and structure in these two diseases is unknown. To elucidate this relationship, we conducted a multimodal fusion analysis on the functional network connectivity (FNC) and gray matter density (GMD) from MRI data from 13 BD, 40 MDD, and 33 matched healthy controls (HC). A data-driven fusion method called mCCA+jICA was used to identify the co-altered FNC and GMD components. We found reduced GMD in the parietal and occipital cortices related to lower FNC in a sensory-motor network as well as stronger interconnection in frontal regions in BD compared to HC. Meanwhile, the MDD group exhibited GMD deficits in the amygdala and cerebellum. Among preliminary classifiers trained using features generated from these group discriminative components, the overall accuracy with resampling and cross-validation reached 91.3% for 3 groups and 99.5% for BD versus MDD. Our findings suggest that both overlapping and unique functional and structural deficits exist in BD and MDD, and the abnormalities may be utilized as potential diagnostic biomarkers.

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Interhemispheric resting state functional connectivity abnormalities in unipolar depression and bipolar depression

Abstract: Depressive episodes in BD and UD have similar impairments of interhemispheric coordination, which might imply an overlap in the neuropathology of depression.

Cited by 117 publications

References 54 publications

Aberrant functional connectivity in depression as an index of state and trait rumination

Aberrant functional connectivity in depression as an index of state and trait rumination

Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder

Co-altered functional networks and brain structure in unmedicated patients with bipolar and major depressive disorders

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