Interindividual variability in the absorption of ciprofloxacin and hydrocortisone from continent ileal reservoir for urine

Mattioli, Francesca; Tognoni, P.; Manfredi, Valeria Graziella Laura; Gosmar, Marzia; Corbu, C.; Garbero, Claudia; Martelli, Antonietta

doi:10.1007/s00228-005-0090-y

Cited by 2 publications

(1 citation statement)

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“…Also other drugs such as phenytoin, theofyllin, lithium, and several antibiotics are known to be reabsorbed in the intestinal segments [35–37]. The clinical significance of this process is difficult to summarize in general terms, since an important interindividual variability in ileal absorption is present [38]. A clinician should be aware of the need for dose adaptations in certain clinical settings.…”

Section: Abnormal Drug Kineticsmentioning

confidence: 99%

Metabolic Changes after Urinary Diversion

Joniau

Branden

et al. 2011

Advances in Urology

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Urinary diversion is performed on a regular basis in urological practice. Surgeons tend to underestimate the metabolic effects of any type of diversion. From the patient's perspective, diarrhea is the most bothersome complaint after urinary diversion. This might be accompanied by malabsorption syndromes, such as vitamin B12 deficiency. Electrolyte abnormalities can occur frequently such as hyperchloremic metabolic acidosis, or less frequently such as hypokalemia, hypocalcaemia, and hypomagnesaemia. Bone health is at risk in patients with urinary diversion. Some patients might benefit from vitamin D and calcium supplementation. Many patients are also subject to urinary calculus formation, both at the level of the upper urinary tract as in intestinal reservoirs. Urinary diversion can affect hepatic metabolism, certainly in the presence of urea-splitting bacteria. The kidney function has to be monitored prior to and lifelong after urinary diversion. Screening for reversible causes of renal deterioration is an integral part of the followup.

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Section: Abnormal Drug Kineticsmentioning

confidence: 99%