Interleukin 10 and clustering of metabolic syndrome components in pediatrics

Chang, Jung Su; Bai, Chyi Huey; Huang, Zu Chieh; Owaga, Eddy; Chao, Kuo Ching; Chang, Chun Chao; Chiou, Hung Yi

doi:10.1111/eci.12247

Cited by 15 publications

(10 citation statements)

References 29 publications

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“…IL-6 and TNF-α are significantly increased in patients with metabolic syndrome 47–49. Previous study showed that the circulating anti-inflammatory cytokine IL-10 concentration is lower in obese children, negatively correlated with percentage of body fat, and can serve as a marker for metabolic risk in children 50. In this study, CRP correlates independently with the cytokines that are known to be associated with metabolic syndrome.…”

Section: Discussionsupporting

confidence: 55%

<p>Association of salivary C-reactive protein with the obesity measures and markers in children</p>

Selvaraju¹,

Babu²,

Geetha³

2019

DMSO

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Objective Overweight and obesity is a pro-inflammatory state. This study aimed to examine the level of the salivary obesity markers in normal weight (NW) and overweight/obese (OW/OB) children, association with the obesity measures and the interrelations between the biomarkers. Subjects and methods Seventy-six children (40 normal weight and 36 overweight/obese) were recruited for this study. Body weight, height, and waist circumference measurement were obtained. The saliva sample was collected from all the participants. According to the Center for Disease Control and Prevention (CDC), the participants were classified into the normal weight or overweight/obese depending upon the body mass index (BMI) percentile ranking. The obesity panel of salivary markers resistin, C-C Motif Chemokine Ligand 2 (CCL2)/monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), complement factor D, and interleukin-10 (IL-10) were determined using human magnetic Luminex performance assay. The receiver operating characteristics (ROC) analysis was used to determine the area under the curve (AUC) to identify the best salivary biomarker in children. Linear regression and Pearson’s correlation analyses to determine the association between the parameters. Results The obesity biomarkers resistin, MCP-1, TNF-α, IL-6 and CRP were significantly high in overweight/obese compared to normal weight. Salivary CRP (AUC: 0.866, 95% CI: 0.780–0.952; p <0.0001) showed superiority area under ROC curves with good discriminatory power than resistin, MCP-1, TNF-α, and IL-6. BMI z-score, WC z-score, and WHtR z-score showed a significant association ( p <0.0001) with CRP. The CRP significantly ( p< 0.0001) correlated with resistin, CCL2/MCP-1, TNF-α, IL-6, and IL-10 by linear regression and Pearson’s correlation analysis. Conclusion Increased level of salivary CRP in children may be considered as a non-invasive marker for childhood obesity for detection of the risk factors for the development of metabolic dysregulation.

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Section: Discussionsupporting

confidence: 55%

<p>Association of salivary C-reactive protein with the obesity measures and markers in children</p>

Selvaraju¹,

Babu²,

Geetha³

2019

DMSO

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“…Interleukin-10 and metabolic syndrome IL-10 is a potent anti-inflammatory cytokine that modulates the immune response in order to prevent excessive activation and auto-damage [36]. Based on its properties, IL-10 plays important roles in modulating insulin resistance and atherosclerotic development and, in a cross-sectional study conducted on children and young adolescents, it has been found that plasmatic IL-10 levels were lower in overweight/obese children, and they concluded that IL-10 could be a marker of metabolic risk [37]. On the contrary, Esposito et al found that IL-10 levels were lower in obese compared with normal weight women, but were lower in both groups that had MetS criteria [38].…”

Section: Interleukin-10mentioning

confidence: 99%

“…Paraoxonase-1 (PON-1) was inversely correlated with the presence of MetS, more precisely with central obesity, hypertriglyceridemia, and hypertension [32][33][34][35]. Interleukin-10 (IL-10) is an anti-inflammatory cytokine, and decreased levels of IL-10 are associated with insulin resistance and the presence of MetS [36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Biomarkers in Metabolic Syndrome

Zlibut¹,

Agoşton-Coldea²,

Mocan³

et al. 2019

Ultimate Guide to Insulin

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Nowadays, biomarkers are useful in the early detection and risk stratification of metabolic syndrome (MetS) patients. Studies confirmed the implication of adipokines, neuropeptides, inflammatory cytokines, prothrombotic factors, and others in MetS pathogenesis. Leptin:adiponectin ratio is useful in predicting insulin resistance and MetS severity; leptin is correlated with obesity and waist size and adiponectin is inversely related with MetS components. Ghrelin is inversely correlated with MetS components, and studies confirmed its role in MetS prediction. Regarding the pro-inflammatory cytokines, studies confirmed that interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha are positively correlated with hypertriglyceridemia, hypertension, fasting glucose levels, insulin resistance, and in postmenopausal women with central obesity. Oxidized low-density lipoprotein (LDL) levels could be implicated in insulin resistance. Recent studies also confirmed that novel biomarkers such as pentraxin-3 are positively correlated with MetS severity and the presence of vascular lesions, and it could bring new data on the MetS mechanism. Within this chapter, we review data on the contribution of biomarkers as well as on the stratification of MetS patients, discussing their key contribution for creating a risk assessment algorithm.

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“…[38][39][40] Interleukin-10 (IL-10), a cytokine, contains variable antiinflammatory properties and controls insulin sensitivity and cholesterol uptake and efflux in macrophages. [41][42][43] IL-10 is produced from many organs, including spleen. It acts via the IL-10 receptor to activate the JAK/STAT pathway and exerts immunosuppressive effects by blocking IκK activity or by inducing tyrosine phosphorylation of STAT-3.…”

Section: Discussionmentioning

confidence: 99%

An update on inflammatory markers in metabolic syndrome

Giri

Lokesh

2021

Int J Adv Med

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Metabolic syndrome is an emerging global threat as a major health burden. It is widely presumed that Metabolic syndrome is associated with a low grade chronic inflammatory phenomenon. This inflammatory state is due to the imbalance between the pro and anti-inflammatory cytokines. Studies have been performed on various inflammatory markers in metabolic syndrome like hsCRP, TNF-alpha, Adiponectin, IL-6, IL-10. Articles were chosen from indexed journals from various search engines. Pro inflammatory cytokines like hsCRP, TNF – alpha, Interleukin -6 were found to be increased and anti-inflammatory cytokines like Interleukin – 10 were reduced in metabolic syndrome.

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Interleukin 10 and clustering of metabolic syndrome components in pediatrics

Abstract: Our data indicate that changes in circulating IL-10 concentrations are marker of metabolic risk in children.

Cited by 15 publications

References 29 publications

<p>Association of salivary C-reactive protein with the obesity measures and markers in children</p>

<p>Association of salivary C-reactive protein with the obesity measures and markers in children</p>

Biomarkers in Metabolic Syndrome

An update on inflammatory markers in metabolic syndrome

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