Interleukin‐11/gp130 upregulates MMP‐13 expression and cell migration in OSCC by activating PI3K/Akt and AP‐1 signaling

Wu, Chia-Yu; Liu, Ju-Fang; Tsai, Hsiao‐Chi; Tzeng, Huey‐En; Hsieh, Tsung Han; Wang, Ming; Lin, Yu‐Feng; Lu, Chien-Chi; Lien, Ming‐Yu; Tang, Chih‐Hsin

doi:10.1002/jcp.30902

Cited by 5 publications

(5 citation statements)

References 38 publications

(59 reference statements)

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“…The role of IL-11 expression was first studied in primary breast cancer, which developed metastasis into the bone [59,60]. IL-11 and its receptor, interleukin-11 receptor α (IL-11Rα) activate STAT3 signaling, which correlates with poor patient prognosis in most human cancers [61][62][63].…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Changes in Cytokine and Chemokine Receptors in Association with Melanoma Liver Metastasis

Koroknai

Szász

Balázs

2023

IJMS

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Cytokines and chemokines (chemotactic cytokines) are soluble extracellular proteins that bind to specific receptors and play an integral role in the cell-to-cell signaling network. In addition, they can promote the homing of cancer cells into different organs. We investigated the potential relationship between human hepatic sinusoidal endothelial cells (HHSECs) and several melanoma cell lines for the expression of chemokine and cytokine ligands and receptor expression during the invasion of melanoma cells. In order to identify differences in gene expression related to invasion, we selected invasive and non-invasive subpopulations of cells after co-culturing with HHSECs and identified the gene expression patterns of 88 chemokine/cytokine receptors in all cell lines. Cell lines with stable invasiveness and cell lines with increased invasiveness displayed distinct profiles of receptor genes. Cell lines with increased invasive capacity after culturing with conditioned medium showed a set of receptor genes (CXCR1, IL1RL1, IL1RN, IL3RA, IL8RA, IL11RA, IL15RA, IL17RC, and IL17RD) with significantly different expressions. It is very important to emphasize that we detected significantly higher IL11RA gene expression in primary melanoma tissues with liver metastasis as well, compared to those without metastasis. In addition, we assessed protein expression in endothelial cells before and after co-culturing them with melanoma cell lines by applying chemokine and cytokine proteome arrays. This analysis revealed 15 differentially expressed proteins (including CD31, VCAM-1, ANGPT2, CXCL8, and CCL20) in the hepatic endothelial cells after co-culture with melanoma cells. Our results clearly indicate the interaction between liver endothelial and melanoma cells. Furthermore, we assume that overexpression of the IL11RA gene may play a key role in organ-specific metastasis of primary melanoma cells to the liver.

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Section: Discussionmentioning

confidence: 99%

Gene Expression Changes in Cytokine and Chemokine Receptors in Association with Melanoma Liver Metastasis

Koroknai

Szász

Balázs

2023

IJMS

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“…Except for the role of ERFE in genomics and chromosomes, our study also identified co-expression of ERFE and IL-11 , a known activator of PI3K-AKT and mTOR signaling pathways [ 43 , 44 ]. In addition, NCAPH expression was also reported to accelerate the tumor progression via PI3K-AKT signaling [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

In Silico Pan-Cancer Analysis Reveals Prognostic Role of the Erythroferrone (ERFE) Gene in Human Malignancies

Altrock

Schmitt

et al. 2023

IJMS

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The erythroferrone gene (ERFE), also termed CTRP15, belongs to the C1q tumor necrosis factor-related protein (CTRP) family. Despite multiple reports about the involvement of CTRPs in cancer, the role of ERFE in cancer progression is largely unknown. We previously found that ERFE was upregulated in erythroid progenitors in myelodysplastic syndromes and strongly predicted overall survival. To understand the potential molecular interactions and identify cues for further functional investigation and the prognostic impact of ERFE in other malignancies, we performed a pan-cancer in silico analysis utilizing the Cancer Genome Atlas datasets. Our analysis shows that the ERFE mRNA is significantly overexpressed in 22 tumors and affects the prognosis in 11 cancer types. In certain tumors such as breast cancer and adrenocortical carcinoma, ERFE overexpression has been associated with the presence of oncogenic mutations and a higher tumor mutational burden. The expression of ERFE is co-regulated with the factors and pathways involved in cancer progression and metastasis, including activated pathways of the cell cycle, extracellular matrix/tumor microenvironment, G protein-coupled receptor, NOTCH, WNT, and PI3 kinase-AKT. Moreover, ERFE expression influences intratumoral immune cell infiltration. Conclusively, ERFE is aberrantly expressed in pan-cancer and can potentially function as a prognostic biomarker based on its putative functions during tumorigenesis and tumor development.

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“…Some evidence already exists for FAK hyperactivation in the setting of other neoplasms, such as colorectal cancer [ 47 ]. Notably, IL11 promotes epithelial-to-mesenchymal transition, and has recently been found to act through the activation of MMP-13 (matrix metalloproteinase 13); the same study described a direct correlation between IL11 expression levels and disease stage in oral SCC [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Molecular and Histopathological Characterization of Metastatic Cutaneous Squamous Cell Carcinomas: A Case–Control Study

Paganelli,

Zaffonato,

Donati

et al. 2024

Cancers

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Background: A subset of patients affected by cutaneous squamous cell carcinoma (cSCC) can exhibit locally invasive or metastatic tumors. Different staging classification systems are currently in use for cSCC. However, precise patient risk stratification has yet to be reached in clinical practice. The study aims to identify specific histological and molecular parameters characterizing metastatic cSCC. Methods: Patients affected by metastatic and non-metastatic cSCC (controls) were included in the present study and matched for clinical and histological characteristics. Skin samples from primary tumors were revised for several histological parameters and also underwent gene expression profiling with a commercially available panel testing 770 different genes. Results: In total, 48 subjects were enrolled in the study (24 cases, 24 controls); 67 genes were found to be differentially expressed between metastatic and non-metastatic cSCC. Most such genes were involved in immune regulation, skin integrity, angiogenesis, cell migration and proliferation. Conclusion: The combination of histological and molecular profiles of cSCCs allows the identification of features specific to metastatic cSCC, with potential implications for more precise patient risk stratification.

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Interleukin‐11/gp130 upregulates MMP‐13 expression and cell migration in OSCC by activating PI3K/Akt and AP‐1 signaling

Cited by 5 publications

References 38 publications

Gene Expression Changes in Cytokine and Chemokine Receptors in Association with Melanoma Liver Metastasis

Gene Expression Changes in Cytokine and Chemokine Receptors in Association with Melanoma Liver Metastasis

In Silico Pan-Cancer Analysis Reveals Prognostic Role of the Erythroferrone (ERFE) Gene in Human Malignancies

Molecular and Histopathological Characterization of Metastatic Cutaneous Squamous Cell Carcinomas: A Case–Control Study

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