2004
DOI: 10.1007/s00125-004-1447-y
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Interleukin-6 and insulin sensitivity: friend or foe?

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Cited by 128 publications
(101 citation statements)
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References 94 publications
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“…While Nappo et al found postprandial IL-6 levels to increase more in subjects with T2D than in non-diabetic individuals [15], our findings corroborate two other studies where neither a mixed meal nor insulin stimulation elicited a differential response in plasma IL-6 in REL and CON [23,30]. Although circulating IL-6 levels did not differ between REL and CON [23,30], elevated baseline IL-6 expression was found in adipose tissue (which secretes up to 35% of IL-6 in resting state [27]) of REL [23] and of insulin resistant subjects [31]. However, we also found higher baseline IL-6 expression in muscle (a tissue pro-ducing very little IL-6 at rest) of REL.…”
Section: Discussionsupporting
confidence: 89%
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“…While Nappo et al found postprandial IL-6 levels to increase more in subjects with T2D than in non-diabetic individuals [15], our findings corroborate two other studies where neither a mixed meal nor insulin stimulation elicited a differential response in plasma IL-6 in REL and CON [23,30]. Although circulating IL-6 levels did not differ between REL and CON [23,30], elevated baseline IL-6 expression was found in adipose tissue (which secretes up to 35% of IL-6 in resting state [27]) of REL [23] and of insulin resistant subjects [31]. However, we also found higher baseline IL-6 expression in muscle (a tissue pro-ducing very little IL-6 at rest) of REL.…”
Section: Discussionsupporting
confidence: 89%
“…Increased IL-6 levels were found in subjects with T2D [28]. Yet, others found comparable IL-6 levels in subjects with T2D, REL, and CON [29], and there was no correlation between basal and insulin-stimulated IL-6 concentrations and insulin resistance [27]. IL-6 infusion was found to increase or not to affect glucose disposal, and to increase lipolysis and fat oxidation [27].…”
Section: Discussionmentioning
confidence: 96%
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“…SOCS1 and SOCS3 mRNA expression were markedly increased by IL6 infusion. This was expected because the genes encoding SOCS proteins are activated by signal transducer and activator of transcription 1 and 3 proteins, which are phosphorylated via activation of the IL6R/gp130 receptor complex (for review see [25]). Immediately after infusion of IL6, RETN and AMP-activated protein kinase (PRKAA1) genes were elevated (p<0.05), while PPARG/ D, TNF, and ADIPOQ showed a tendency (p<0.15) to be elevated.…”
Section: Il6 Infusion Increases Adipose Tissue Expression Of Metabolimentioning
confidence: 99%
“…Thus, increased secretion of IL-6 in the view of obesity, IR and type 2 DM, as well as a higher risk of the development of type 2 DM with in persons with high level of IL-6, which indicates the decreased insulin sensitivity under the action of this cytokine. In another research, it was shown that IL-6 exerts a dual effect: in the liver cells and adipocytes it inhibits the action of insulin, results in the formation of IR, while in the cells of skeletal muscles, vice versa, IL-6 enhances the effects of insulin and contributes to uptake and disposal of glucose and lipids [17]. Probably it accounts for the diversity and, at times, contradistinction of effects of IL-6 upon the metabolic processes, especially upon the action of insulin in tissues, as well as the data obtained by us as to decrease of IL-6 and oncostatin M in patients with EH and prediabetes and type 2 DM.…”
Section: Discussionmentioning
confidence: 99%