Interleukin-6 and interleukin-17 gene polymorphism association with celiac disease in children

Akbulut, Ulaş Emre; Çebi, Alper Han; Sağ, Elif; İkbal, Mevlit; Çakır, Murat

doi:10.5152/tjg.2017.17092

Cited by 16 publications

(15 citation statements)

References 24 publications

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“…The list of shared genetic loci between CD and T1D are likely to be increased by more comprehensive studies. Some other genetic polymorphisms that have been associated with an elevated risk of CD in the context of T1D include rs10754558 and rs358294199 SNPs of NLRP3 (42), polymorphisms in IL - 6 (43, 44), CD14 (45, 46), and IL12A/SCHIP, CCR1, CCR2, CCr3, LPP, IL-17 (44, 47-49). …”

Section: Resultsmentioning

confidence: 99%

An Overview of Celiac Disease in Childhood Type 1 Diabetes

Shahramian

Bazi

Sargazi

2018

Int J Endocrinol Metab

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ContextCeliac disease (CD) is a common phenomenon in children with Type 1 diabetes (T1D). In the present review, we have discussed the pathogenesis, diagnostic biomarkers, risk factors, and prognosis of CD in the context of pediatric T1D.Evidence AcquisitionLiterature published in Web of Science, PubMed, Scopus, Google Scholar, and Cochrane Library were scrutinized up to the end of 2017. The keywords of celiac disease, Type 1 diabetes, children, and pediatric were used in different combinations.ResultsImmune cytotoxic reactions along with dampen immune regulatory functions contribute to CD in the context of pediatric T1D. Many children with simultaneous CD and T1D do not represent with the clinical signs of the enteropathy rendering a diagnostic challenge. The most common screening tests in these children are routine serological tests of CD, anti - endomysial, anti - transglutaminase, and anti - deamidated gliadin peptide antibodies. Typing for human leukocyte antigens of DQ - 2 and DQ - 8 may assist in the diagnosis of silent CD in children with T1D. The most significant shared non - HLA genetic loci of CD and T1D comprise CTLA - 4, TAGAP, IL - 18RAP, PTPN2, RGS1, SH2B3, CCR5. Interactions between these loci can be important in susceptibility to CD in T1D. Some new biomarkers have been suggested for diagnosis of CD including ischemia-modified albumin (IMA), soluble syndecan-1 (SSDC-1), regenerating gene Iα (REG-Iα), Neurotensin, and Zonulin, which can be useful for diagnosis and screening of CD in childhood T1D.ConclusionsOverall, active seropositive CD seems to be of clinical importance in T1D with significant impacts on the quality of life and predisposition to diabetes associated complications. It is important to detect CD in the context of T1D to prevent potential risks contributing to morbidities and mortalities associated with either CD or T1D.

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Section: Resultsmentioning

confidence: 99%

An Overview of Celiac Disease in Childhood Type 1 Diabetes

Shahramian

Bazi

Sargazi

2018

Int J Endocrinol Metab

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“…Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted via activated T-cells, which produces an immune response to exogenous fungal and bacterial pathogens and plays a role in the development of inflammatory and autoimmune diseases [6].IL-17A, also called IL17, is the most important IL from the IL17 family which comprises 6 members (IL17A→IL17F). IL17 is produced by T helper 17 cells and contributes to both acquired and innate immune responses against exogenous pathogens.…”

Section: Introductionmentioning

confidence: 99%

A Study of the Association Between IL-17 and HOMA-IR in Iraqi Type 2 Diabetic Patients

Abbas

Alaaraji

Alâ€“Shawk

2020

eijs

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Type 2 Diabetes Mellitus (T2DM) is the furthermost common form of DM which is identified by hyperglycemia, insulin resistance, and relative insulin deficiency. This study aims to detect the role of interleukin-17 (IL-17) in patients with T2DM compared with the healthy control and to investigate the relationship between IL-17 and insulin resistance. The study involved 50 Iraqi T2DM patients, randomly selected with an age range of 33-71 years .For the purpose of comparison, 30 Iraqi healthy persons with an age range of 33-71 years were also included. Patients and control groups were characterized in terms of gender, age, body mass index (BMI), homeostatic model assessment-insulin resistance(HOMA-IR),fasting serum glucose (FSG) and lipid profile. The means of IL-17 (368.45 vs. 128.50 pg/ml), HOMA-IR (7.94vs. 2.14),FSG (152.82 vs. 81.53 mg/dl), fasting serum insulin (FSI) level (19.37 vs. 10.71 μIU/ml), Triglycerides (TG), High Density Lipoprotein (HDL),and Very Low Density Lipoprotein (VLDL) were significantly higher in T2DM patients as compared to controls. While, levels of Total Cholesterol (TC)and Low Density Lipoprotein (LDL)showed non-significant differences. In conclusion, IL-17 seems to play a significant role as a risk factor for the development of T2DM.Also, higher (HOMA-IR) gives rise to a hyperglycemic state and is a major risk factor for the development of T2DM.

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“…The IL-17 family members are pro-inflammatory cytokines mainly released by T-helper 17 (Th17) cells. IL-17 gene variants have been found to be linked with numerous autoimmune diseases, such as asthma [47], celiac disease [48], and inflammatory bowel disease [49]. Reduced synthesis of IL-6, IL-12, IL-17A, IFN-gamma, and high levels of IL-13 cytokines due to ovalbumin stimulation in alcohol-consuming mice have also been reported [50].…”

Section: Discussionmentioning

confidence: 99%