Internal and external surface features of newly developed porous ceramics with random interconnected 3D channels by a fibrous sacrificial porogen method

Mocanu, Aura-Cătălina; Miculescu, Marian; Machedon-Pisu, Teodor; Maidaniuc, Andreea; Ciocoiu, Robert; Ioniță, Mariana; Pasuk, Iuliana; Stan, George E.; Miculescu, Florin

doi:10.1016/j.apsusc.2019.05.354

Cited by 25 publications

(30 citation statements)

References 49 publications

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“…With respect to the NIST SRM2910b, the 10MgHAp bioceramic contained a higher amount of adsorbed water (to be expected for a compound synthesized by a wet-chemistry technology), as evidenced by the more intense bands associated to the characteristic bending (~1630–1670 cm −1 ) and stretching (~2700–3700 cm −1 ) vibrations of water molecules (Figure 10b,c). The shallow band peaking at ~2900 cm −1 in the case of NIST-SRM 2910b appertains to various C–H stretching vibrations, the consequence of an accidental minor sample contamination during storing or handling [52]. Furthermore, it should be emphasized that the 10MgHAp is also carbonated (Figure 10a,b).…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, and Antimicrobial Activity of Magnesium-Doped Hydroxyapatite Suspensions

et al. 2019

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Obtaining nanoscale materials has allowed for the miniaturization of components, which has led to the possibility of achieving more efficient devices with faster functions and much lower costs. While hydroxyapatite [HAp, Ca10(PO4)6(OH)2] is considered the most widely used material for medical applications in orthopedics, dentistry, and general surgery, the magnesium (Mg) is viewed as a promising biodegradable and biocompatible implant material. Furthermore, Mg is regarded as a strong candidate for developing medical implants due to its biocompatibility and antimicrobial properties against gram-positive and gram-negative bacteria. For this study, magnesium-doped hydroxyapatite (Ca10−xMgx (PO4)6 (OH)2, xMg = 0.1), 10MgHAp, suspensions were successfully obtained by an adapted and simple chemical co-precipitation method. The information regarding the stability of the nanosized 10MgHAp particles suspension obtained by ζ-potential analysis were confirmed for the first time by a non-destructive ultrasound-based technique. Structural and morphological studies of synthesized 10MgHAp were conducted by X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy in attenuated total reflectance (ATR) mode and scanning electron microscopy (SEM). The XRD analysis of the 10MgHAp samples confirmed that a single crystalline phase associated to HAp with an average grain size about 93.3 nm was obtained. The FTIR-ATR spectra revealed that the 10MgHAp sample presented broader IR bands with less visible peaks when compared to a well-crystallized pure HAp. The SEM results evidenced uniform MgHAp nanoparticles with spherical shape. The antimicrobial activity of the 10MgHAp suspension against gram-positive strains (Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212), gram-negative strains (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853), as well as a fungal strain (Candida albicans ATCC 90029) were evaluated.

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Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, and Antimicrobial Activity of Magnesium-Doped Hydroxyapatite Suspensions

et al. 2019

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“…In the case of 10MgHAp-Dex-thyme powder and coating, supplemental IR maxima were evidenced in the spectral regions not superimposed by the more prominent HAp characteristic vibration modes, namely: vibrations of α-(1,3) linkages of glycoside units in dextran (~760-761 cm −1 ) [49][50][51][52][53], out-of-plane wagging vibrations of C-H in thymol units (~818 cm −1 , more evident in the case of the powder) [54][55][56] The FTIR-ATR spectra of simple 10MgHAp powders, 10MgHAp-Dex-thyme powder, and coating are presented comparatively in Figure 10, together with the reference spectra of raw dextran powder and thyme oil. The vibration bands distinctive to a B-type carbonated hydroxyapatite [30,[45][46][47][48] were evidenced for all studied bioceramic-based materials, i.e., ν 4 bending (~558 and~599-600 cm −1 ), ν 1 symmetric stretching (~950-951 cm −1 ), and ν 3 asymmetric stretching (~1004-1013 and~1097-1099 cm −1 ) of (PO 4 ) 3− groups; libration of structural (OH) − units (~630 cm −1 ); and ν 2 bending (~872-873 cm −1 ) and ν 3 asymmetric stretching (~1418-1424 and~1456-1478 cm −1 ) vibrations of (CO 3 ) 2− groups (Figure 10a,b,d,e,g,h). All materials were strongly hydrated, as evidenced by the intense wide bands appertaining to the bending (~1630-1640 cm −1 ) and stretching (~2700-3700 cm −1 ) vibrations of adsorbed water molecules (Figure 10c,f,i) [30,[45][46][47][48].…”

Section: Resultsmentioning

confidence: 99%

“…Comparative FTIR-ATR spectra of the (a-c) 10MgHAp (dotted line) and 10MgHAp-Dex-thyme powders (solid line); (d-f) dextran and thyme essential oil raw materials; and (g-i) 10MgHAp-Dex-thyme coating, zoomed over three relevant (a,d,g) fingerprint and (b,c,e,f,h,i) functional groups regions: (a,d,g) 500-1180 cm −1 ; (b,e,h) 1180-1800 cm −1 ; and (c,f,i) 2500-3750 cm −1 . [30,[45][46][47][48] Nowadays, due to the appearance of microorganisms resilient to conventional therapies, studies regarding the antimicrobial effects of various types of possible antimicrobial agents, such as metallic ions (copper, iron, silver, magnesium, zinc), inorganic nanoparticles, or essential oils, are performed in the search for efficient solutions with a wider action range against pathogens [1,2,18,20,22,38,58]. In this paper, we investigated for the first time, the influence of Mg-doped HAp enhanced with thyme essential oil in a dextran matrix, in both solution and coating form, on the development of microbial biofilms of some of the most prevalent fungal and Gram-positive and Gram-negative bacterial strains.…”

Section: Resultsmentioning

confidence: 99%

Dextran-Thyme Magnesium-Doped Hydroxyapatite Composite Antimicrobial Coatings

et al. 2020

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The dextran-thyme magnesium-doped hydroxyapatite (10MgHAp-Dex-thyme) composite layers were prepared by a dip-coating procedure from stable suspensions and further analyzed for the first time. Different characterization techniques were employed to explore the physical-chemical features of the 10MgHAp-Dex-thyme suspensions and derived coatings. Information regarding the 10MgHAp-Dex-thyme suspensions was extracted on the basis of dynamic light scattering, zeta potential, and ultrasound measurements. The crystalline quality of the biocomposite powders—resulting after the centrifugation of suspensions—and the layers deposited on glass was assessed by X-ray diffraction in symmetric and grazing incidence geometries, respectively. The chemical structure and presence of functional groups were evaluated for both powder and coating by Fourier transform infrared spectroscopy in attenuated total reflectance mode. The extent of the antimicrobial effect range of the biocomposite suspensions and coatings was tested against different Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa) and fungus (Candida albicans) strains with promising results.

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“…Comparing the compressive strength values of the experimental samples with those of the 342 cortical bone, values of approximatively four times smaller than those of the cortical bone in the 343 longitudinal direction were noticed ( Table 2). The obtained results show lower values than those of 344 the consecrated metallic materials used in medicine [66][67][68] but higher than values than those of the 345 ceramic ones [19,69,70]. In contrast, for compressive loading on cortical bone, rapid hardening occurs after yielding, followed by softening.…”

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confidence: 70%

Novel Synthesis of Core-Shell Biomaterials from Polymeric Filaments with a Bioceramic Coating for Biomedical Applications

et al. 2020

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Bone tissue engineering is constantly in need of new material development with improved biocompatibility or mechanical features closer to those of natural bone. Other important factors are the sustainability, cost, and origin of the natural precursors involved in the technological process. This study focused on two widely used polymers in tissue engineering, namely polylactic acid (PLA) and thermoplastic polyurethane (TPU), as well as bovine-bone-derived hydroxyapatite (HA) for the manufacturing of core-shell structures. In order to embed the ceramic particles on the polymeric filaments surface, the materials were introduced in an electrical oven at various temperatures and exposure times and under various pressing forces. The obtained core-shell structures were characterized in terms of morphology and composition, and a pull-out test was used to demonstrate the particles adhesion on the polymeric filaments structure. Thermal properties (modulated temperature and exposure time) and the pressing force's influence upon HA particles' insertion degree were evaluated. More to the point, the form variation factor and the mass variation led to the optimal technological parameters for the synthesis of core-shell materials for prospect additive manufacturing and regenerative medicine applications.Coatings 2020, 10, 283 2 of 18 importance. Among these, PLA was widely used, mainly due to its biocompatibility with the human organism and the advantageous synthesis alternative from sustainable natural resources (e.g., beet or maize) [14]. Along with PLA, TPU was remarked in the additive manufacturing technology [15]. The TPU applications in the medical field spread from blood vessels, implants, and prosthetics, to scaffolding in tissue engineering, dialysis membranes, or breast implants [16].Furthermore, naturally derived hydroxyapatite (HA) is a bioactive ceramic, with similar chemical and structural properties to the mineral component of the natural bone tissue, and exceptional biocompatibility and osteoconductivity. HA can be synthesized from various renewable resources (e.g. fish, sheep, cattle or bovine bones [17,18] or marine shells [19,20]).Along with the development of new biomaterials, the cost-efficient and highly performant processing techniques for final products manufacturing are also in need of improvement. Additive manufacturing (AM) or 3D printing can be considered 21st century technology due to the possibility to attain patient-customized and adapted products [14]. However, the most widely and accessible used technique in orthopedics is fused deposition modeling (FDM) or fused filler fabrication (FFF) [8,14,21,22], which provide 3D scaffolds with a well-defined design by extruding a digital 3D model from thermoplastic polymeric materials heated to their melting point [22].This study aims to provide a new core-shell material that can be used in the FDM technique, targeted due to its rigorous control of parameters (temperature, bed temperature, feed rate, printing speed, etc.) [23][24][25][26][27].Therefore, thi...

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Internal and external surface features of newly developed porous ceramics with random interconnected 3D channels by a fibrous sacrificial porogen method

Cited by 25 publications

References 49 publications

Synthesis, Characterization, and Antimicrobial Activity of Magnesium-Doped Hydroxyapatite Suspensions

Synthesis, Characterization, and Antimicrobial Activity of Magnesium-Doped Hydroxyapatite Suspensions

Dextran-Thyme Magnesium-Doped Hydroxyapatite Composite Antimicrobial Coatings

Novel Synthesis of Core-Shell Biomaterials from Polymeric Filaments with a Bioceramic Coating for Biomedical Applications

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