Internal effect concentrations of organic substances for early life development of egg-exposed fish

Foekema, E.M.; Parron, M. Lopez; Mergia, Mekuria Teshome; Carolus, Elisa R.M.; Berg, Johannes H.J. vd; Kwadijk, Christiaan; Dao, Q. T.; Murk, Albertinka J.

doi:10.1016/j.ecoenv.2013.12.006

Cited by 25 publications

(16 citation statements)

References 66 publications

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“…For instance, concentrations of PCBs in urban storm waters reached more than 400 and 700 ng/L in Switzerland (Rossi et al, 2004) and France (Zgheib et al, 2012) respectively. Also, a major route of exposure of fish early life stages to dioxin-like compounds is via maternal transfer, which can result in increase of internal concentrations through the mobilization of the yolk reserves (Daley et al, 2014;Foekema et al, 2014). Thus, the pFET test covers an exposure scenario of high environmental and biological relevance.…”

Section: Discussionmentioning

confidence: 99%

“…When deposited maternally or accumulated during early life exposure in the yolk-sac of embryos, such compounds can be released during mobilization of lipids at later developmental periods, leading to bioamplification and increased toxicity (Daley et al, 2014). Indeed, in common sole (Solea solea), early life stage exposure to polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) was shown to cause delayed mortality (Foekema et al, 2008;Foekema et al, 2014). The onset of delayed mortality coincided with the transition from yolk-sac to the free-feeding larval stage, the moment when the yolk lipids become depleted.…”

Section: Introductionmentioning

confidence: 99%

“…PCB126, an aryl hydrocarbon receptor (AhR) agonist recommended as reference chemical in investigations of dioxin-like toxicity (Van den Berg et al, 1998), caused delayed toxic effects in sole, such as oedema, delayed development and mortality (Foekema et al, 2008;Foekema et al, 2014). While flatfish represent a convenient test model among marine fish species, zebrafish is the freshwater fish test species adopted by several test guidelines (ISO, 2007;OECD, 2013aOECD, , 2013b.…”

Section: Introductionmentioning

confidence: 99%

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Early life exposure to PCB126 results in delayed mortality and growth impairment in the zebrafish larvae

et al. 2015

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The occurrence of chronic or delayed toxicity resulting from the exposure to sublethal chemical concentrations is an increasing concern in environmental risk assessment. The Fish Embryo Toxicity (FET) test with zebrafish provides a reliable prediction of acute toxicity in adult fish, but it cannot yet be applied to predict the occurrence of chronic or delayed toxicity. Identification of sublethal FET endpoints that can assist in predicting the occurrence of chronic or delayed toxicity would be advantageous. The present study characterized the occurrence of delayed toxicity in zebrafish larvae following early exposure to PCB126, previously described to cause delayed effects in the common sole. The first aim was to investigate the occurrence and temporal profiles of delayed toxicity during zebrafish larval development and compare them to those previously described for sole to evaluate the suitability of zebrafish as a model fish species for delayed toxicity assessment. The second aim was to examine the correlation between the sublethal endpoints assessed during embryonal and early larval development and the delayed effects observed during later larval development. After exposure to PCB126 (3-3000ng/L) until 5 days post fertilization (dpf), larvae were reared in clean water until 14 or 28 dpf. Mortality and sublethal morphological and behavioural endpoints were recorded daily, and growth was assessed at 28 dpf. Early life exposure to PCB126 caused delayed mortality (300 ng/L and 3000 ng/L) as well as growth impairment and delayed development (100 ng/L) during the clean water period. Effects on swim bladder inflation and cartilaginous tissues within 5 dpf were the most promising for predicting delayed mortality and sublethal effects, such as decreased standard length, delayed metamorphosis, reduced inflation of swim bladder and column malformations. The EC50 value for swim bladder inflation at 5 dpf (169 ng/L) was similar to the LC50 value at 8 dpf (188 and 202 ng/L in two experiments). Interestingly, the patterns of delayed mortality and delayed effects on growth and development were similar between sole and zebrafish. This indicates the comparability of critical developmental stages across divergent fish species such as a cold water marine flatfish and a tropical freshwater cyprinid. Additionally, sublethal effects in early embryo-larval stages were found promising for predicting delayed lethal and sublethal effects of PCB126. Therefore, the proposed method with zebrafish is expected to provide valuable information on delayed mortality and delayed sublethal effects of chemicals and environmental samples that may be extrapolated to other species.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Early life exposure to PCB126 results in delayed mortality and growth impairment in the zebrafish larvae

et al. 2015

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“…(Kookana et al 1998;Matthies 2003). As HOCs are generally highly toxic, their wide spread in the environment poses serious hazards to the environment and the public health (Fent 2003;Jager et al 2005;Foekema et al 2014). For example, 16 PAHs are on the US EPA list of priority pollutants, which are the target group of contaminants in this study.…”

Section: Introductionmentioning

confidence: 95%

Efficient oxidation of high levels of soil-sorbed phenanthrene by microwave-activated persulfate: implication for in situ subsurface remediation engineering

Peng

Deng

2015

J Soils Sediments

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Purpose In situ chemical oxidation using activated persulfate is increasingly applied for source destruction of hydrophobic organic contaminants (HOCs), e.g., PAHs, the target group contaminants of this study. However, the low aqueous solubility and strong sequestration of HOCs by soil aggregates are major hurdles for the oxidation of HOCs in the subsurface. This study aimed to investigate the potential of using microwave-activated persulfate to tackle the above issues and accelerate the remediation of HOC-contaminated sites. Materials and methods Soil sorbed with high levels of phenanthrene, a model compound for PAHs, was used in the study. The effects of microwave, reaction temperature, reaction time, oxidant dosage, and soil to water ratio on the destruction of phenanthrene, persulfate consumption, and slurry pH were studied. Furthermore, the mechanisms of the microwaveactivated process were discussed by comparing the degradation results using microwave-activated persulfate with those using conventional heat-activated persulfate, and potential microwave-specific effects were explored.Results and discussion This study shows that microwaveactivated persulfate is highly effective toward the destruction of high levels of soil-sorbed phenanthrene. The results indicate that higher slurry temperature is critical to initiate a positive feedback loop that induces rapid and efficient destruction of phenanthrene. Furthermore, potential mechanisms of the positive feedback loop were discussed. Though persulfate is mainly activated by the thermal effect of microwave, nonthermal microwave-specific effects were preliminary observed, which induce additional activation of persulfate and further enhance the destruction efficiency of phenanthrene. In addition, how to integrate an in situ microwave soil heating system with the traditional persulfate remediation process for subsurface engineering was discussed to provide guidance for potential applications in field scales. Conclusions Overall, the feasibility of using microwave heating to accelerate persulfate remediation of subsurface organic contaminations was established.

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“…This implies that, during larval development, tissue POP concentrations become higher than the concentrations in the adult mother fish. Experiments with early life stages of the marine flatfish Solea solea that were exposed as eggs to mixtures of lipophilic POPs extracted from adult sole from a heavily contaminated estuary indicated that mainly dioxin-like PCBs were responsible for the observed mortality [30]. Based on these findings and information that fish early life stages in general are very sensitive to dioxin-like toxicity [31][32][33], the present study focuses on the risk that dioxin-like compounds may pose to the early life stages of eel.…”

Section: Pop Accumulation and Effect Of Maternal Transfermentioning

confidence: 99%

Maternally transferred dioxin‐like compounds can affect the reproductive success of European eel

Foekema¹,

Kotterman²,

Vries³

et al. 2015

Enviro Toxic and Chemistry

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Reported concentrations of dioxin-like compounds accumulated in the European eel (Anguilla anguilla) were used to perform a risk assessment for eel larval survival, taking into account a modeled amplification of tissue concentrations with a factor of 1.33 during spawning migration. The calculated concentrations of dioxin-like compounds finally deposited in the eggs were compared with the internal effect concentrations for survival of early life stages of the European eel; these concentrations, by lack of experimental data, were estimated from a sensitivity distribution based on literature data by assuming that eel larvae are among the 10% most sensitive teleost fish species. Given concentrations of dioxin-like contaminants and assuming a relatively high sensitivity, it can be expected that larvae from eggs produced by eel from highly contaminated locations in Europe will experience increased mortality as a result of maternally transferred dioxin-like contaminants. As historical persistent organic pollutant concentrations in eel tissue were higher, this impact must have been stronger in the past. Potential effects of other compounds or effects on the migration, condition, and fertility of the parental animals were not taken into account. It is important to further study the overall impact of contaminants on the reproductive success of the European eel as this may have been underestimated until now.

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Internal effect concentrations of organic substances for early life development of egg-exposed fish

Cited by 25 publications

References 66 publications

Early life exposure to PCB126 results in delayed mortality and growth impairment in the zebrafish larvae

Early life exposure to PCB126 results in delayed mortality and growth impairment in the zebrafish larvae

Efficient oxidation of high levels of soil-sorbed phenanthrene by microwave-activated persulfate: implication for in situ subsurface remediation engineering

Maternally transferred dioxin‐like compounds can affect the reproductive success of European eel

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