Internal Lethal Concentrations of Halobenzenes with Fish (Gambusia affinis)

Chaisuksant, Yupadee; Qian, Yu; Connell, Des

doi:10.1006/eesa.1997.1524

Cited by 40 publications

(56 citation statements)

References 29 publications

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“…It has already been demonstrated that normalization of LBBs on fat content reduces the variation within one population . In addition, variation in timeto-death may influence LBBs (De Bruijn et al, 1991;De Wolf et al, 1991;Kleiner et al, 1993;Ohayo-Mitoko and Deneer, 1993;Mortimer and Connell, 1994;Chaisuksant et al, 1997). The role of these and other possible factors will be discussed in the present study.…”

Section: Introductionmentioning

confidence: 84%

“…The studies that use different aquaria and exposure concen- Chaisuksant et al (1997) a ↑, LBB increases with time-to-death. trations analyze time-dependency by comparing mean LBB and mean time-to-death for the different aquaria.…”

Section: Time-to-deathmentioning

confidence: 97%

“…Influence of time-to-death on LBB has been studied and discussed before (Van Hoogen en Opperhuizen, 1988, De Bruijn et al, 1991, De Wolf et al, 1991, Kleiner et al, 1993Ohayo-Mitoko and Deneer, 1993, Mortimer and Connell, 1994, Chaisuksant et al, 1997.…”

Section: Time-to-deathmentioning

confidence: 97%

“…In these studies a constant LBB or a decrease in LBB with time is found ( Table 3). The latter time-dependency is explained in various ways: higher amount of adsorption of the test compound at high exposure/low time-to-death conditions (Tas et al, 1991); shift of mode of toxic action (De Bruijn et al, 1991); increased stress after long exposure (Chaisuksant et al, 1997); timedelay between reaching LBB and death (Mortimer and Connoll, 1994). The most likely explanation may depend on both test compound and exposure conditions.…”

Section: Time-to-deathmentioning

confidence: 99%

See 3 more Smart Citations

Lipid Content and Time-to-Death-Dependent Lethal Body Burdens of Naphthalene and 1,2,4-Trichlorobenzene in Fathead Minnow (Pimephales promelas)

Maagd

Klundert

Wezel

et al. 1997

Ecotoxicology and Environmental Safety

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Section: Introductionmentioning

confidence: 84%

Section: Time-to-deathmentioning

confidence: 97%

Section: Time-to-deathmentioning

confidence: 97%

Section: Time-to-deathmentioning

confidence: 99%

See 2 more Smart Citations

Lipid Content and Time-to-Death-Dependent Lethal Body Burdens of Naphthalene and 1,2,4-Trichlorobenzene in Fathead Minnow (Pimephales promelas)

Maagd

Klundert

Wezel

et al. 1997

Ecotoxicology and Environmental Safety

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“…using a Varian-3400 gas chromatography with Ni electron capture detector following Chaisuksant et al (1997b).…”

Section: Effects Of Halobenzenes On Growth Rate Of Fishmentioning

confidence: 99%

Effects of Halobenzenes on Growth Rate of Fish (Gambusia affinis)

Chaisuksant

Qian

Connell

1998

Ecotoxicology and Environmental Safety

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Toxicokinetics and toxicodynamics of nickel in Enchytraeus crypticus

He¹,

Gestel²

2013

Enviro Toxic and Chemistry

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Metal toxicity is usually determined at a fixed time point, which may bias the assessment of risks associated with varied exposure time. Time-dependent accumulation and toxicity of nickel in the potworm Enchytraeus crypticus were investigated in solutions embedded in an inert quartz sand matrix. Internal Ni concentration and mortality were determined at 7 different time intervals and interpreted from the perspective of toxicokinetics and toxicodynamics. A 1-compartment model was used to describe the uptake and elimination kinetics of Ni. At each exposure concentration, Ni concentration in the organisms increased with increasing exposure time, reaching equilibrium after approximately 14 d. Median lethal concentration (LC50) decreased with time and reached an ultimate value of 0.182 mg/L. The LC50 values expressed as internal Ni concentrations (LC50inter) were almost constant (16.7 mg/kg body dry wt) at each exposure time. The LC50inter was independent of exposure time, suggesting that internal concentration was a better indicator of Ni toxicity than external concentration. The uptake rate constant was 11.9 L/kg/d, and elimination rate constants were 0.325/d (based on internal concentration) and 0.070/d (based on survival), indicating that not all internal Ni contributes to toxicity. The present study highlights the importance of taking time into account in future toxicity testing and risk assessment practices.

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Internal Lethal Concentrations of Halobenzenes with Fish (Gambusia affinis)

Cited by 40 publications

References 29 publications

Lipid Content and Time-to-Death-Dependent Lethal Body Burdens of Naphthalene and 1,2,4-Trichlorobenzene in Fathead Minnow (Pimephales promelas)

Lipid Content and Time-to-Death-Dependent Lethal Body Burdens of Naphthalene and 1,2,4-Trichlorobenzene in Fathead Minnow (Pimephales promelas)

Effects of Halobenzenes on Growth Rate of Fish (Gambusia affinis)

Toxicokinetics and toxicodynamics of nickel in Enchytraeus crypticus

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