Interrelationship between chronic periodontitis and anemia: A 6-month follow-up study

Abstract

Background:In India, anemia is a common and serious health disorder among both sexes and all age groups, with anemia of chronic disease (ACD) being the second most prevalent anemia. Periodontitis is an inflammatory disease of the supporting tissues of the tooth caused by specific microorganisms. An immune response to bacteria and their products induces a major vascular response, offering explanatory mechanisms for the interactions between periodontal infection and a variety of systemic disorders. Therefore, periodontitis results in low-grade systemic inflammation, which may cause lower number of erythrocytes and, consequently, lower hemoglobin concentration.Materials and Methods:A total of 100 systemically healthy male patients visiting the outpatient department participated in the study. Of these, 50 patients had healthy periodontium and 50 patients had chronic periodontitis. Clinical parameters and red blood cell parameters of all the patients were assessed at baseline and 6 months after non-surgical periodontal therapy. Statistical analysis using Student's t-test was performed.Results:Data analysis revealed that patients with chronic periodontitis showed an improvement in both clinical and red blood cell parameters from baseline to 6 months after non-surgical periodontal therapy.Conclusion:From the present study, it can be concluded that like any other chronic condition, chronic periodontitis can lead to ACD. It also provides evidence that non-surgical periodontal therapy can improve the anemic status of patients with chronic periodontitis.

Chronic periodontitis and serum levels of hepcidin and hemoglobin

“…In the group of individuals with chronic periodontitis, both hematocrit values and those of serum iron were lower than in participants without periodontitis. The lowest hematocrit value in this group can be attributed to less number of red blood cells in individuals with periodontal infection, according to the results of previous studies (Kolte et al, 2014;Patel et al, 2014). Small serum iron values in participants with periodontitis were observed, reinforcing the character of anemia of chronic disease, and consequent blocking of intracellular iron release.…”

Decreased Hemoglobin Concentration and Iron Metabolism Disorder in Periodontitis: Systematic Review and Meta-Analysis

“…Hb, RBC counts, hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular Hb (MCH), mean corpuscular Hb concentration (MCHC), and erythrocyte sedimentation rate (ESR) (Hutter et al, 2001;Gokhale et al, 2010;Naik et al, 2010;Prakash et al, 2012;Chakraborty et al, 2014;Kolte et al, 2014;Patel et al, 2014;Khan et al, 2015;Latha et al, 2015;Anumolu et al, 2016;Carvalho et al, 2016;Nibal et al, 2019).…”

Oral Lesions in Kidney Transplant Recipients

“…It has recently been shown that diff erent chronic oral conditions such as periodontitis can be related to diff erent systemic diseases, e.g., anemia of chronic disease 40 . Posttransplant anemia is a chronic condition related to erythropoietin substitution and blood transfusion.…”