Chronic periodontitis and serum levels of hepcidin and hemoglobin

Carvalho, Rosana Costa Casanovas de; Leite, Sandra Augusta Moura; Rodrigues, Vandílson Pinheiro; Pereira, A F V; Ferreira, Teresa Cristina Alves; Nascimento, Flávia R.F.; Nascimento, Johnny Ramos do; Filho, Isaac Suzart Gomes; Bastos, Marcus Gomes

doi:10.1111/odi.12373

Cited by 14 publications

(14 citation statements)

References 12 publications

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“…In a previous short communication with the same baseline data as those of the present study, no statistically significant differences were observed in the level of hepcidin between the groups with or without CP, 32 whereas another study found differences in serum hepcidin levels between CP and control groups; 33 however, this study also included patients with type 2 diabetes mellitus, and it presented less strict eligibility criteria, which may have contributed to the inclusion of patients with other systemic diseases, leading to differences between the study findings.…”

Section: Discussionsupporting

confidence: 66%

The effect of nonsurgical periodontal therapy on hepcidin and on inflammatory and iron marker levels

et al. 2019

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Serum hepcidin levels may increase in response to infection and inflammation. The present study investigated the effect of nonsurgical periodontal therapy (NSPT) on levels of serum hepcidin, inflammatory markers, and iron markers. An interventional study was conducted on 67 patients (age 30-65 years) without other diseases, except for chronic periodontitis (CP). Patients were allocated to either CP or control groups. The CP group received supragingival and subgingival scaling and root planing procedures, whereas the control group received supragingival scaling. Probing depth (PD), bleeding on probing, clinical attachment level (CAL), visible plaque index (VPI), serum hepcidin and interleukin-6 (IL-6) levels, highsensitivity C-reactive protein (hs-CRP), hematological markers, and iron markers were measured at baseline and at 90 days after NSPT. The CP group had statistically significant lower mean values for mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) (p ≤ 0.05). The control group had statistically significant reductions in hemoglobin, hematocrit, MCV, and MCH (p ≤ 0.05). Serum hepcidin, IL-6, and erythrocyte sedimentation rate (ESR) levels were significantly decreased in both groups after NSPT. Periodontal markers were more markedly reduced in the CP group compared with the control group (p ≤ 0.05). These findings suggest that NSPT may reduce the serum levels of IL-6, hepcidin, and periodontal parameters.

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Section: Discussionsupporting

confidence: 66%

The effect of nonsurgical periodontal therapy on hepcidin and on inflammatory and iron marker levels

et al. 2019

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“…diabetes and bone loss). The relationship between iron metabolism and periodontitis was previously investigated, and no significant serum iron and serum hepcidin modification was found (Carvalho et al., ) in patients with periodontitis compared to healthy subjects. To the best of our knowledge, the present study is the first to explore the periodontal status of patients with haemochromatosis.…”

Section: Discussionmentioning

confidence: 99%

Periodontal status and serum biomarker levels in HFE haemochromatosis patients. A case‐series study

Meuric

Lainé

Boyer

et al. 2017

J Clinic Periodontology

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“…A study by Anand et al found that patients with generalized aggressive periodontitis, in comparison with health controls, were susceptible to lower red blood cell (RBC) counts and lower hemoglobin (Hb) levels (Anand et al, 2014). However, there were several references in argument of a non-coincidental association (Enhos et al, 2009;Carvalho et al, 2016). Hence, the aim of the present study was to evaluate the alterations of the level of hematological parameters and iron metabolism markers in patients with or without periodontitis.…”

Section: Introductionmentioning

confidence: 87%

“…Hb, RBC counts, hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular Hb (MCH), mean corpuscular Hb concentration (MCHC), and erythrocyte sedimentation rate (ESR) (Hutter et al, 2001;Gokhale et al, 2010;Naik et al, 2010;Prakash et al, 2012;Chakraborty et al, 2014;Kolte et al, 2014;Patel et al, 2014;Khan et al, 2015;Latha et al, 2015;Anumolu et al, 2016;Carvalho et al, 2016;Nibal et al, 2019).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…In addition, iron metabolism markers reflecting AI (serum iron, transferrin, and ferritin) and an iron state regulator (hepcidin) were included in this systematic review and metaanalysis. Four publications evaluated the effect of periodontitis on serum iron (Craig et al, 2003;Prakash et al, 2012;Thomas et al, 2013;Carvalho et al, 2016). Two articles on transferrin (Carvalho et al, 2016;Shirmohamadi et al, 2016), four references on ferritin (Prakash et al, 2012;Chakraborty et al, 2014;Latha et al, 2015;Carvalho et al, 2016), and two studies on hepcidin (Carvalho et al, 2016;Guo et al, 2018) were also included.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Decreased Hemoglobin Concentration and Iron Metabolism Disorder in Periodontitis: Systematic Review and Meta-Analysis

Zhang

Cao

et al. 2020

Front. Physiol.

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Background: Periodontitis is a chronic inflammatory disease with a possible infectious component. Anemia of inflammation (AI) occurring in various chronic diseases alters the hemoglobin (Hb) concentration and iron status. Currently, the association between periodontitis and AI is still controversial. The aim of this study was to assess the alterations of the level of hematological parameters and iron metabolism markers in patients with or without periodontitis. Methods: Electronic databases (MEDLINE, EMBASE, and Cochrane) were searched to identify publications about anemia and periodontitis. Subgroup analyses regarding gender, extent of periodontitis, and sample size were performed using STATA 12.1. Results: Sixteen studies were included in this meta-analysis. Pooled results showed a decrease in Hb [standardized mean difference (SMD) = −0.76, 95% CI = (−1.15, −0.37)], red blood cell [SMD = −0.69, 95% CI = (−1.09, −0.29)], hematocrit [SMD = −1.13, 95% CI = (−1.69, −0.57)], mean corpuscular volume [SMD = −0.16, 95% CI = (−0.32, −0.01)], and mean corpuscular Hb [SMD = −0.16, 95% CI = (−0.28, −0.04)], but upregulation in erythrocyte sedimentation rate [SMD = 0.63, 95% CI = (0.06, 1.19)]. In addition, patients with periodontitis had a higher level of hepcidin [SMD = 0.59, CI = (0.05, 1.12)] and decreased level of transferrin [SMD = −4.6, CI = (−13.1, −3.90)], with high heterogeneity. Conclusion: This meta-analysis indicates that periodontitis decreases Hb concentration and disturbs the balance of iron metabolism, which confirms strength of association between periodontitis and the development tendency of AI, especially for severe periodontitis. More unbiased cohort studies with larger sample sizes are still warranted to make a definitive judgment in the future.

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Chronic periodontitis and serum levels of hepcidin and hemoglobin

Abstract: There is no reference range for hepcidin. AE s.d. = standard deviation. IQR = interquartile range (1st quartile-3rd quartile). M = male values. F = female values.

Cited by 14 publications

References 12 publications

The effect of nonsurgical periodontal therapy on hepcidin and on inflammatory and iron marker levels

The effect of nonsurgical periodontal therapy on hepcidin and on inflammatory and iron marker levels

Periodontal status and serum biomarker levels in HFE haemochromatosis patients. A case‐series study

Decreased Hemoglobin Concentration and Iron Metabolism Disorder in Periodontitis: Systematic Review and Meta-Analysis

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