The effect of nonsurgical periodontal therapy on hepcidin and on inflammatory and iron marker levels

Abstract

Serum hepcidin levels may increase in response to infection and inflammation. The present study investigated the effect of nonsurgical periodontal therapy (NSPT) on levels of serum hepcidin, inflammatory markers, and iron markers. An interventional study was conducted on 67 patients (age 30-65 years) without other diseases, except for chronic periodontitis (CP). Patients were allocated to either CP or control groups. The CP group received supragingival and subgingival scaling and root planing procedures, whereas the control group received supragingival scaling. Probing depth (PD), bleeding on probing, clinical attachment level (CAL), visible plaque index (VPI), serum hepcidin and interleukin-6 (IL-6) levels, highsensitivity C-reactive protein (hs-CRP), hematological markers, and iron markers were measured at baseline and at 90 days after NSPT. The CP group had statistically significant lower mean values for mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) (p ≤ 0.05). The control group had statistically significant reductions in hemoglobin, hematocrit, MCV, and MCH (p ≤ 0.05). Serum hepcidin, IL-6, and erythrocyte sedimentation rate (ESR) levels were significantly decreased in both groups after NSPT. Periodontal markers were more markedly reduced in the CP group compared with the control group (p ≤ 0.05). These findings suggest that NSPT may reduce the serum levels of IL-6, hepcidin, and periodontal parameters.

Ferroptosis: A New Development Trend in Periodontitis

“…However, inflammatory mediators, such as interleukin-6 (IL-6) and bacterial lipopolysaccharides, produced upon microbial stimulation interfere with the regulation of iron homeostasis by hepcidin, further exacerbating intracellular iron retention and circulating iron levels decrease [ 94 ]. This was further supported in studies related to periodontitis [ 95 , 96 ]. Therefore, we speculate that although the body has made a series of defensive changes to the “iron overload” state of periodontitis, these changes may exacerbate the vicious circle of “iron overload” to a certain extent under the stimulation of periodontal infection.…”

The effectiveness of the use of polypeptide drugs and their effect on the metabolic parameters of oral fluid in patients with generalized periodontitis in depending on blood type

“…Calcium concentration was studied colorimetrically in alkaline medium. The content of Fe in the serum was determined without deproteinization with FerroZain dye, the concentration of which is proportional to the concentration of Fe in the sample (Leite et al 2019). The research was performed on an automatic biochemical analyser "Hitachi-902", "Untegra 800" from "Roche" (Japan), using a commercial set of reagents "Roche" (Germany).…”

Title Effect of Non-surgical Periodontal Therapy (NSPT) on the Systemic Inflammatory Markers (IL-6 and IL-8) in β-Thalassemia Patients with Gingivitis

“…Non-surgical periodontal therapy (NSPT) is the gold standard in the treatment and management of periodontal inflammatory conditions (28). Evidence supports consistent improvement in clinical periodontal inflammatory markers in various patient population as well as improvement in systemic inflammatory markers following NSPT (29).…”